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Peter Attia

Expert insight on health, performance, longevity, critical thinking, and pursuing excellence. Dr. Peter Attia (Stanford/Hopkins/NIH-trained MD) talks with leaders in their fields.

The Peter Attia Drive

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Ted Schaeffer is an internationally recognized urologist specializing in prostate cancer and a returning guest on The Drive. In this episode, Ted provides insights into the role testosterone plays, or doesn't play, in the initiation and progression of prostate cancer. He unpacks the findings and limitations of the recent TRAVERSE trial, exploring the complex relationship between testosterone and prostate cancer. Ted delves into the molecular nature of prostate cancer, explaining the androgen receptor saturation theory and the potential impact of testosterone on cancer growth. He also discusses the use of the Decipher test to predict cancer aggressiveness and guide targeted treatment. Furthermore, Ted shares how he counsels patients regarding testosterone replacement therapy (TRT), including its safe administration in patients with low-grade prostate cancer. Additionally, he highlights advancements in prostate cancer therapies and biomarkers that help develop precise treatment strategies while minimizing the need for broad androgen deprivation therapy.
 
We discuss:
 
 • Background on the TRAVERSE trial: insights into exogenous testosterone and prostate cancer risk [3:00];
 • The androgen receptor saturation theory: how different organs respond to varying levels of testosterone [10:30];
 • The relationship between testosterone levels and prostate cancer aggressiveness: how aggressive prostate tumors have lower androgen receptor activity and rely on different growth mechanisms [16:15];
 • Using the Decipher score to assess prostate cancer aggressiveness and guide personalized treatment strategies [23:45];
 • Considerations for testosterone replacement therapy: how Ted counsels patients, how TRT can be safely administered in patients with low-grade prostate cancer, and more [31:15];
 • Advancements in prostate cancer therapies and PSA as a biomarker for precise treatment decisions, minimizing the need for broad androgen deprivation therapy [38:30]; and
 • More.
 
Connect With Peter on Twitter, Instagram, Facebook and YouTube

#310 - The relationship between testosterone and prostate cancer, testosterone replacement therapy, and tools for predicting cancer aggressiveness and guiding therapy | Ted Schaeffer, M.D., Ph.D.

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In this "Ask Me Anything" (AMA) episode, Peter dives deep into one of the most frequently discussed and often misunderstood topics: nutrition. From weight loss and maintenance to the intricate relationship between nutrition and exercise and body composition, Peter addresses the complexities of nutrition research and explores the perennial question of whether there is a "best diet." He provides practical insights on how to choose the right diet for your unique needs, discusses the role of protein and processed foods, and outlines the key questions to help you optimize your approach to eating.
 
If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #66 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.
 
We discuss:
 
 • The key nutrition-related topics to be discussed [1:30];
 • Why Peter is not fond of discussing nutrition: limitations of nutrition research, the pitfalls of extreme certainty in dietary discussions, and the body's adaptability to varied diets [3:30];
 • Key health metrics to monitor to evaluate the effects of nutrition [9:30];
 • The relationship between nutrition and exercise as they relate to weight loss, maintenance, and gain [12:30];
 • How increased muscle mass from resistance training impacts calorie burn, body composition, glucose metabolism, and overall health benefits [19:45];
 • Comparing the impact of fitness and nutrition on lifespan and healthspan: data showing fitness to be a more significant predictor of mortality than nutrition [23:30];
 • The myth of a “best diet,” factors that determine the effectiveness of a diet, and data suggesting benefits of the Mediterranean diet [39:00];
 • How long to trial a new diet, the importance of measurable goals, and the appropriate timescales for observing meaningful changes [48:30];
 • The inherent challenges in nutrition research: variability in dietary exposures, limitations in study design, the body’s adaptive nature which dampen the effects, and more [51:15];
 • Nutritional approaches for chronic diseases like cardiovascular disease and type 2 diabetes [58:45];
 • Emerging studies on dietary interventions for non-alcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated steatotic liver disease (MASLD) [1:02:45];
 • Practical considerations for individuals to identify the best diet for them: protein intake, energy balance, macronutrient adjustments, and micronutrient levels [1:06:00];
 • Understanding processed vs. ultra-processed foods [1:09:15];
 • The effects of ultra-processed foods on health [1:12:30];
 • Questions that someone should ask themselves if they’re looking to fine-tune their diet [1:18:15]; and
 • More.
 
Connect With Peter on Twitter, Instagram, Facebook and YouTube

#328 - AMA #66: Optimizing nutrition for health and longevity: myth of a “best” diet, complexities of nutrition science, and practical steps for building a sustainable diet

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In this special episode of The Drive, Peter tackles a wide range of listener questions submitted over the past year. The discussion spans essential topics such as exercise—covering grip strength, traveling workouts, and why Peter doesn’t consider exercise an ideal weight-loss strategy—and the top biomarkers everyone should track. He also explores promising new longevity research, his evolving views on longevity, and frameworks like “objective, strategy, tactics” for personalized decision-making. The episode wraps up with insights on building good habits and a glimpse into Peter’s recent reading list.
 
If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the Special AMA show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.
 
We discuss:
 
 • Overview of episode topics (and Peter’s car stereo saga) [1:45];
 • The importance of grip strength and the best methods for training it effectively [3:45];
 • Exercise while traveling: strategies for staying active and maintaining an exercise routine [14:45];
 • Why women should prioritize strength training [18:00];
 • The limited role of exercise in weight loss and its greater importance in improving health, body composition, and insulin sensitivity [19:45];
 • The “top five most important biomarkers” for assessing health [22:45];
 • Promising developments in longevity research [28:15];
 • The development of Klotho as a neuroprotective drug: challenges, timelines of trials, and more [34:00];
 • Peter’s updated view on the potential of epigenome manipulation to restore aged cells to their youthful state [39:45];
 • How reversing age-related epigenetic changes in immune cells could revolutionize our approach to aging and disease [43:30];
 • The “objective, strategy, tactics” framework, and the importance prioritizing impactful lifestyle habits over less significant health trends [49:30];
 • Strategies for building and maintaining good habits [56:45];
 • How to think about drugs and supplements as part of a longevity toolkit [1:02:00];
 • Peter’s recent reading list [1:05:15]; and
 • More.
 
Connect With Peter on Twitter, Instagram, Facebook and YouTube

#329 ‒ Special AMA: Peter on exercise, important labs, building good habits, promising longevity research, and more

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James Clear is the author of the New York Times bestseller Atomic Habits. His extensive research into human behavior has helped him identify key components of habit formation and develop the “Four Laws of Behavioral Change.” In this episode, James provides insights into how both good and bad habits are formed, including the influence of genetics, environment, social circles, and more. He points to changes one can make to cultivate more perseverance and discipline and describes the profound impact habits can have when tying them into one’s self-identity. Finally, James breaks down his “Four Laws of Behavioral Change” and how to use them to create new habits, undo bad habits, and make meaningful changes in one’s life.
 
We discuss:
 
 • Why James became deeply interested in habits [2:00];
 • Viewing habits through an evolutionary lens [6:15];
 • The power of immediate feedback for behavior change, and why we tend to repeat bad habits [9:30];
 • The role of genetics and innate predispositions in determining one’s work ethic and success in a given discipline [14:45];
 • How finding one’s passion can cultivate perseverance and discipline [23:30];
 • Advantages of creating systems and not just setting goals [29:30];
 • The power of habits combined with self-identity to induce change [36:45];
 • How a big environmental change or life event can bring on radical behavioral change [50:45];
 • The influence of one’s social environment on their habits [54:30];
 • How and why habits are formed [1:00:45];
 • How to make or break a habit with the “Four Laws of Behavior Change” [1:09:45];
 • Practical tips for successful behavioral change—the best strategies when starting out [1:16:30];
 • Self-forgiveness and getting back on track immediately after slipping up [1:30:45];
 • Law #1: Make it obvious—Strategies for identifying and creating cues to make and break habits [1:40:00];
 • Law #2: Make it attractive—examples of ways to make a new behavior more attractive [1:48:00];
 • Law #3: Make it easy—the 2-minute rule [1:59:00];
 • Law #4: Make it satisfying—rewards and reinforcement [2:03:45];
 • Advice for helping others to make behavioral changes [2:06:15]; and
 • More.
 
Connect With Peter on Twitter, Instagram, Facebook and YouTube

Building & Changing Habits | James Clear (#183 rebroadcast)

Welcome to a special sneak peek of The Peter Attia Drive. The Peter Attia Drive will feature guests and experts that will offer advice and insight to help you optimize performance, health, longevity, critical thinking, and life. It’s hosted by Stanford M.D., TED speaker, and longevity expert Dr. Peter Attia, founder of Attia Medical, PC, a medical practice with offices in San Diego and New York City.
 
Learn more at www.PeterAttiaMD.com
 Connect with Peter on Facebook | Twitter | Instagram.

#00 - Sneak Peek: The Peter Attia Drive

Excited to kick off the podcast with special guest and close friend Tim Ferriss, lifehacker, podcaster extraordinaire, and author of multiple best-selling books that includes The 4-Hour Workweek, The 4-Hour Body, Tools of Titans, and Tribe of Mentors.
 
In this podcast we cover mental health, depression, and our mutual interest in psychedelics as potential therapeutic agents. Tim talks both experientially and from his own deep dive into the literature of psychedelics and mental health. Tim is shifting his focus from investing in startups to funding experiments that he hopes will establish more reliable knowledge and therapeutic options for those suffering from anxiety, depression, and addiction.
 
Tim also shared his list of acquired wisdom he returns to most reliably, which might be worth the price of admission alone.
 
 
 
We discuss:
 
 • Tim’s history of depression and his TED Talk on his close call with suicide [11:15];
 • The type of thinking that triggers Tim’s downward spirals [17:15];
 • Tim’s transformative experience with ayahuasca [48:45];
 • How Tim’s experience and research has led him to focus on furthering the science on psychedelics and mental health [53:00];
 • What some of the meditation modalities, and meditation apps, are out there, why meditation can be so hard to do, but also worthwhile to stick with [1:13:00];
 • Why Tim made a big commitment (more than $1 million) to funding scientific research, and to psilocybin and MDMA research, in particular [1:31:00];
 • From all the habits and tools that Tim has learned, the five things that he returns to most reliably [2:33:00];
 • And more.
 
Learn more at www.PeterAttiaMD.com
 Connect with Peter on Facebook | Twitter | Instagram

#01 - Tim Ferriss: depression, psychedelics, and emotional resilience

Rhonda and I go on a Nerd Safari into the jungle of health, nutrition, fitness, performance, and longevity. We visit IGF-1 and whether there’s a tradeoff of having high or low levels. We discuss the PPARs (receptor proteins) and genetic polymorphisms. Does Rhonda think there’s any benefit in a NAD+ booster for health and longevity? Can saunas lower the risk of heart disease, dementia, and all-cause mortality? 
 
Rhonda is a wealth of knowledge on so many topics and was the perfect companion to dig into so many fun topics in this episode. She puts a ton of thought into her research and it really shows in this conversation.
 
 
 
We discuss:
 
 • What Rhonda believes differently today than she did a few years ago [5:40];
 • The paradox of GH/IGF-1 in performance and longevity [21:00];
 • The role of PPAR in fat metabolism and ketogenic diets [23:00];
 • The possible genetic explanations for why some patients don’t respond well to a ketogenic diet [31:00];
 • The health benefits of heat and cold exposure [1:12:30];
 • NAD+ [1:32:45];
 • And more.
 
Learn more at www.PeterAttiaMD.com
 Connect with Peter on Facebook | Twitter | Instagram

#02 - Rhonda Patrick, Ph.D.: the performance and longevity paradox of IGF-1, ketogenic diets and genetics, the health benefits of sauna, NAD+, and more

Whenever I’m stumped on a patient case or in my thinking about lipids, Ron is one of the first people I turn to for insight. Ron is recognized globally for his research into lipidology and has worn many hats in his career, including clinician, lipidologist, nutrition, genetics, and drug research.
 
In this episode, we explore heart disease at its origins before diving into the highly discussed, largely misunderstood, role of LDL and inflammation in atherosclerosis. Ron also shares his insights on the evidence for and against statins and other lipid-lowering therapies. My hope is that both the curious patient and the physician can get a lot out of this episode by being more informed about dyslipidemia and the interventions used to reduce the risk of atherosclerotic disease. We covered a lot of ground on this critically important topic.
 
 
 
We discuss:
 
 • The pathogenesis of atherosclerosis [7:00];
 • How early atherosclerosis begins [12:40];
 • Ron’s motivation for getting into lipidology [43:00];
 • How reading an article series in the NEJM in 1967 had a profound impact on him and his career [43:30];
 • How PCSK9 inhibitors work and why they may be under-utilized [47:00];
 • Mendelian randomization: nature’s randomized trial [49:15];
 • The “battle” between particle size and particle number [52:00];
 • The use of statins [1:04:45];
 • The role of chronic inflammation in atherosclerosis [1:24:15];
 • Why niacin may have been unjustly dismissed as a therapeutic option [1:40:45];
 • The HDL paradox: why drugs that raise HDL-C seem to raise (or have little impact on) heart disease risk [1:43:00];
 • Lp(a) [1:47:45];
 • And more.
 
 Learn more at www.PeterAttiaMD.com
 
 Connect with Peter on Facebook | Twitter | Instagram

#03 - Ron Krauss, M.D.: a deep dive into heart disease

In his first “Ask Me Anything” episode, Peter answered your questions submitted to him via Twitter.
 
We discuss:
 
 • What are Peter’s thoughts on alcohol consumption and health? [4:00]
 • What are the best lab tests to request from your PCP, and what are the best markers for longevity? [14:00]
 • What are the best wearables and why, and why does Peter use a continuous glucose monitor? [35:00]
 • How does one select the right physician as a patient? [47:00]
 • Why does Peter race cars and what’s the hardest thing to learn as a new driver? [54:30]
 • What is Peter’s current exercise regimen and what are his thoughts on exercise for improving lifespan and healthspan? [1:20:15]
 • What is Peter’s strategy for learning something deeply? [1:33:00]
 • What is Peter’s process for forming his beliefs? [1:53:30]
 • What does Peter’s diet look like these days? [1:57:45]
 • And more.
 
 Learn more at www.PeterAttiaMD.com
 
 Connect with Peter on Facebook | Twitter | Instagram.

#04 - AMA #1: alcohol, best lab tests, wearables, finding the right doc, racing, and more

Dom digs deep into the research and application of ketogenic diets, exogenous ketones, hyperbaric oxygen treatment, and treating cancer with a metabolic approach. Plus, we lost track of the number of n=Dom experiments mentioned in this episode.
 
We discuss:
 
 • Dom’s early medical training in hyperbaric chambers [
7:00 • ];
 • Effect of ketones on cancer cells [
20:00 • ];
 • Ketones and oxygen toxicity seizures [32:00];
 • HBOT & its many applications [40:00];
 • Ketones, MCTs, and exogenous ketones [59:15];
 • How ketones affect blood glucose [
1:20:00 • ];
 • Ketone esters, salts, enantiomers vs. racemic BOHB [
1:38:00 • ];
 • Dom’s ketone tolerance test [
1:56:00 • ];
 • The metabolic management of cancer with a Press-Pulse approach [1:59:45]; and
 • More.
 
 Learn more at www.PeterAttiaMD.com
 
 Connect with Peter on Facebook | Twitter | Instagram.

#00 - Sneak Peek: The Peter Attia Drive

#00 - Sneak Peek: The Peter Attia Drive

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