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The Peter Attia Drive

Af
- MD
- Peter Attia

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Afsnit: 400
Gns. varighed: 1T 15M
Sprog: Engelsk
Format
Kategori: Personlig udvikling

Expert insight on health, performance, longevity, critical thinking, and pursuing excellence. Dr. Peter Attia (Stanford/Hopkins/NIH-trained MD) talks with leaders in their fields.

Episodes

#331 ‒ Optimizing endurance performance: metrics, nutrition, lactate, and more insights from elite performers | Olav Aleksander Bu (Pt. 2)View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter’s Weekly Newsletter Olav Aleksander Bu is an internationally renowned sports scientist acclaimed for his coaching prowess with elite athletes spanning a diverse range of sports disciplines. In this episode, Olav returns to dive deeper into his groundbreaking work as an endurance coach, exercise scientist, engineer, and physiologist. The discussion explores his data-driven approach to coaching, unpacking key performance metrics like functional threshold power, VO2 max, and lactate threshold, while emphasizing the importance of consistent testing protocols. Olav shares insights on how training methodologies differ across sports, the impact of nutrition on endurance performance, and the evolving strategies for carbohydrate metabolism in fueling athletes for races. Olav concludes with a discussion on the use of artificial intelligence for optimizing training insights and performance. We discuss: • Olav’s unique, engineering-driven approach to endurance coaching [2:45]; • Definitions and applications of key performance metrics: FTP, power, anaerobic threshold, and lactate threshold [4:45]; • Lactate threshold: factors affecting lactate threshold, testing protocols, and how elite athletes' efficiency affects their performance and lactate profiles [14:15] • VO2 max: definition, testing, factors affecting its accuracy, and methods for optimizing oxygen utilization in elite athletes [22:15]; • Testing VO2 max: common mistakes and key factors to consider—preparation, warm-up, timing, and more [34:00]; • VO2 max testing continued: measuring instruments, testing protocols, and advanced insights gained from elite athletes [41:45]; • The influence of supplements like beetroot concentrate and adaptogens on VO2 max and performance [49:45]; • How respiratory quotient (RQ) reflects metabolic shifts during exercise, the challenges in measuring and interpreting RQ in elite athletes, and the physiological adaptations needed for prolonged endurance events [53:30]; • Triathlon training: the challenge of maintaining elite performance across triathlon distances, metabolic efficiency, and swimming challenges [1:03:15]; • How reducing drag in swimming could revolutionize performance and the role of biofeedback tools in optimizing efficiency across various endurance sports [1:07:00]; • How endurance athletes prioritize effort regulation using RPE, heart rate, and power output, and the role of lactate in cardiac and athletic efficiency [1:20:00]; • Lactate’s role as a fuel, buffering methods to combat lactic acidosis, and the variability in athlete response to bicarbonate supplementation [1:25:45]; • The physiological mechanisms behind differences in performance between two elite athletes: lactate transport, cardiovascular efficiency, and compensatory systems [1:33:00]; • Comparing interventions like acetaminophen to enhance performance in high-heat conditions versus natural adaptations to heat [1:37:15]; • Advancements in nutrition science, changes in cyclist body composition, and the impact of fueling strategies on athletic performance and growth [1:39:30]; • Optimizing endurance performance with utilization of carbohydrates, and the potential role of ketones [1:48:00]; • Insights gained from elite performers in the 2020 and 2024 Olympics [1:58:30]; • The use of artificial intelligence to optimizing training insights and performance [2:06:30]; and • More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
380
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2T 16M
#338 ‒ Peter’s takeaways on aerobic exercise and VO2 max, insulin resistance, rising healthcare costs, treating children with autism and ADHD, and strength training | Quarterly Podcast Summary #4View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter’s Weekly Newsletter In this quarterly podcast summary (QPS) episode, Peter summarizes his biggest takeaways from the last three months of guest interviews on the podcast. Peter shares key insights from his discussions on diverse topics such as aerobic efficiency and VO2 max with Olav Aleksander Bu; insulin resistance with Ralph DeFronzo; economics of the US healthcare system and cost-saving strategies with Saum Sutaria; diagnosis and treatment of autism, ADHD, and anxiety in children with Trenna Sutcliffe; and strength training with Mike Israetel. Additionally, Peter shares any personal behavioral adjustments or modifications to his patient care practices that have arisen from these fascinating discussions. If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the episode #338 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: • Overview of topics to be discussed [2:00]; • Olav Aleksander Bu Pt.2 episode: metrics to track aerobic efficiency and insights about VO2 max, and the ability of increased carbohydrate consumption to boost performance [4:30]; • The best practices for performing a VO2 max test, the differences between VO2 max training and all-out efforts, and the role of energy intake in endurance performance [14:45]; • Ralph DeFronzo episode: the pathophysiology of insulin resistance and type 2 diabetes—how they impact different organs, flaws in conventional diabetes treatment, and more [24:30]; • Understanding type 2 diabetes beyond the traditional triumvirate of features: the “ominous octet” describes changes in other organs [31:45]; • Pharmacological treatments for insulin resistance and type 2 diabetes [41:30]; • The importance of early detection and intervention in insulin resistance [50:30]; • Saum Sutaria episode: the economic and systemic drivers of high healthcare costs in the U.S. [54:00]; • Reducing health care costs: redefining health insurance, lowering drug prices while maintaining innovation, leveraging AI for efficiency, and more [1:07:15]; • Trenna Sutcliffe episode: insights on autism, ADHD, and anxiety in children—definitions and diagnosis [1:11:45]; • Exploring the rising prevalence of autism spectrum disorder [1:17:15]; • Trenna’s views on caring for children with autism [1:21:15]; • Misconceptions around vaccines and autism [1:26:00]; • Mike Israetel episode: insights about strength training, minimum effective dose, troubleshooting plateaus, tips for beginners, and more [1:28:15]; • Topics Peter is interested in exploring in future podcasts [1:40:15]; and • More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
387
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27M
#347 – Peter’s takeaways on mastering sleep, dealing with chronic pain, developing breakthrough cancer drugs, transforming healthcare with AI, advancing radiation therapy, and healing trauma | Quarterly Podcast Summary #5View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter’s Weekly Newsletter In this quarterly podcast summary (QPS) episode, Peter summarizes his biggest takeaways from the last three months of guest interviews on the podcast. Peter shares key insights from his discussions with Jeff English on the journey to healing from trauma; Ashley Mason on improving sleep and CBT-I; Sanjay Mehta on misconceptions around radiation and its use in cancer therapy and treating inflammatory conditions (such as arthritis and tendonitis); Sean Mackey on understanding and treating acute and chronic pain; and Susan Desmond-Hellmann on insights from her extraordinary career that pertain to the use of AI in medicine, understanding cancer, and the development of cancer therapeutics. Additionally, Peter shares any behavioral changes he’s made for himself or his patients as a result of these fascinating discussions. If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the episode #347 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: • Summary of episode topics [1:45]; • Jeff English episode: how trauma shapes behavior and identity, and the value of understanding personal adaptations and working through unresolved emotional wounds [3:45]; • Practical behavioral changes and emotional tools Peter has applied since the Jeff English episode [13:00]; • Ashley Mason episode: treating insomnia using CBT-I and practical behavioral techniques for improving sleep quality [19:15]; • When to seek professional care for sleep issues [30:30]; • Sanjay Mehta episode: radiation therapy’s evolution, its underused potential in treating inflammatory conditions, and the cultural misconceptions surrounding radiation exposure [33:45]; • Peter’s predictions and insights for the upcoming Formula 1 season [43:15]; • Sean Mackey episode: the neuroscience, classifications, and treatment strategies for chronic pain, and the importance of personalized care [57:45]; • Susan Desmond-Hellmann episode: how AI is revolutionizing medicine through advancements in drug development, biomarker discovery, and the potential of training models on private clinical data [1:05:45]; • More from Susan Desmond-Hellmann: why cancer is so difficult to treat with drugs, the promise of immunotherapy, and the long-term hope for systemic treatments [1:14:00]; and • More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
396
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33M
#206 - Exercising for longevity: strength, stability, zone 2, zone 5, and moreView the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter’s Weekly Newsletter In this special episode of The Drive, we have pulled together a variety of clips from previous podcasts about exercise to help listeners understand this topic more deeply, as well as to identify previous episodes which may be of interest. In this episode, Peter discusses his framework for exercise, what he’s really optimizing for, and how to train today to be prepared for a good life at age 100. He describes the importance of strength and stability, and why deadlifting is an important tool to consider for longevity. Additionally, he details why training in zone 2 and zone 5 is important, gives a primer on VO2 max, and describes the most effective ways to engage in those types of exercise. Finally, Peter reveals his current exercise routine. We discuss: • What is Peter optimizing for with his exercise? [3:00]; • Preparing for a good life at age 100: Training for the “Centenarian Olympics” [6:00]; • The importance of preserving strength and muscle mass as we age [21:45]; • The value of deadlifts for stability and longevity when done properly [27:30]; • The importance of zone 2 aerobic training [35:45]; • The most effective ways to engage in zone 2 exercise [40:00]; • Zone 5 training and VO2 max [44:15]; • A primer on VO2 max [52:00]; • Stability—the cornerstone upon which all exercise and movement relies [1:03:00]; • Peter’s current exercise routine [1:07:45]; • More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
242
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1T 14M
#328 - AMA #66: Optimizing nutrition for health and longevity: myth of a “best” diet, complexities of nutrition science, and practical steps for building a sustainable dietView the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter’s Weekly Newsletter In this "Ask Me Anything" (AMA) episode, Peter dives deep into one of the most frequently discussed and often misunderstood topics: nutrition. From weight loss and maintenance to the intricate relationship between nutrition and exercise and body composition, Peter addresses the complexities of nutrition research and explores the perennial question of whether there is a "best diet." He provides practical insights on how to choose the right diet for your unique needs, discusses the role of protein and processed foods, and outlines the key questions to help you optimize your approach to eating. If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #66 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: • The key nutrition-related topics to be discussed [1:30]; • Why Peter is not fond of discussing nutrition: limitations of nutrition research, the pitfalls of extreme certainty in dietary discussions, and the body's adaptability to varied diets [3:30]; • Key health metrics to monitor to evaluate the effects of nutrition [9:30]; • The relationship between nutrition and exercise as they relate to weight loss, maintenance, and gain [12:30]; • How increased muscle mass from resistance training impacts calorie burn, body composition, glucose metabolism, and overall health benefits [19:45]; • Comparing the impact of fitness and nutrition on lifespan and healthspan: data showing fitness to be a more significant predictor of mortality than nutrition [23:30]; • The myth of a “best diet,” factors that determine the effectiveness of a diet, and data suggesting benefits of the Mediterranean diet [39:00]; • How long to trial a new diet, the importance of measurable goals, and the appropriate timescales for observing meaningful changes [48:30]; • The inherent challenges in nutrition research: variability in dietary exposures, limitations in study design, the body’s adaptive nature which dampen the effects, and more [51:15]; • Nutritional approaches for chronic diseases like cardiovascular disease and type 2 diabetes [58:45]; • Emerging studies on dietary interventions for non-alcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated steatotic liver disease (MASLD) [1:02:45]; • Practical considerations for individuals to identify the best diet for them: protein intake, energy balance, macronutrient adjustments, and micronutrient levels [1:06:00]; • Understanding processed vs. ultra-processed foods [1:09:15]; • The effects of ultra-processed foods on health [1:12:30]; • Questions that someone should ask themselves if they’re looking to fine-tune their diet [1:18:15]; and • More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
376
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16M
#329 ‒ Special AMA: Peter on exercise, important labs, building good habits, promising longevity research, and moreView the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter’s Weekly Newsletter In this special episode of The Drive, Peter tackles a wide range of listener questions submitted over the past year. The discussion spans essential topics such as exercise—covering grip strength, traveling workouts, and why Peter doesn’t consider exercise an ideal weight-loss strategy—and the top biomarkers everyone should track. He also explores promising new longevity research, his evolving views on longevity, and frameworks like “objective, strategy, tactics” for personalized decision-making. The episode wraps up with insights on building good habits and a glimpse into Peter’s recent reading list. If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the Special AMA show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: • Overview of episode topics (and Peter’s car stereo saga) [1:45]; • The importance of grip strength and the best methods for training it effectively [3:45]; • Exercise while traveling: strategies for staying active and maintaining an exercise routine [14:45]; • Why women should prioritize strength training [18:00]; • The limited role of exercise in weight loss and its greater importance in improving health, body composition, and insulin sensitivity [19:45]; • The “top five most important biomarkers” for assessing health [22:45]; • Promising developments in longevity research [28:15]; • The development of Klotho as a neuroprotective drug: challenges, timelines of trials, and more [34:00]; • Peter’s updated view on the potential of epigenome manipulation to restore aged cells to their youthful state [39:45]; • How reversing age-related epigenetic changes in immune cells could revolutionize our approach to aging and disease [43:30]; • The “objective, strategy, tactics” framework, and the importance prioritizing impactful lifestyle habits over less significant health trends [49:30]; • Strategies for building and maintaining good habits [56:45]; • How to think about drugs and supplements as part of a longevity toolkit [1:02:00]; • Peter’s recent reading list [1:05:15]; and • More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
377
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27M
Building & Changing Habits | James Clear (#183 rebroadcast)View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter’s Weekly Newsletter James Clear is the author of the New York Times bestseller Atomic Habits. His extensive research into human behavior has helped him identify key components of habit formation and develop the “Four Laws of Behavioral Change.” In this episode, James provides insights into how both good and bad habits are formed, including the influence of genetics, environment, social circles, and more. He points to changes one can make to cultivate more perseverance and discipline and describes the profound impact habits can have when tying them into one’s self-identity. Finally, James breaks down his “Four Laws of Behavioral Change” and how to use them to create new habits, undo bad habits, and make meaningful changes in one’s life. We discuss: • Why James became deeply interested in habits [2:00]; • Viewing habits through an evolutionary lens [6:15]; • The power of immediate feedback for behavior change, and why we tend to repeat bad habits [9:30]; • The role of genetics and innate predispositions in determining one’s work ethic and success in a given discipline [14:45]; • How finding one’s passion can cultivate perseverance and discipline [23:30]; • Advantages of creating systems and not just setting goals [29:30]; • The power of habits combined with self-identity to induce change [36:45]; • How a big environmental change or life event can bring on radical behavioral change [50:45]; • The influence of one’s social environment on their habits [54:30]; • How and why habits are formed [1:00:45]; • How to make or break a habit with the “Four Laws of Behavior Change” [1:09:45]; • Practical tips for successful behavioral change—the best strategies when starting out [1:16:30]; • Self-forgiveness and getting back on track immediately after slipping up [1:30:45]; • Law #1: Make it obvious—Strategies for identifying and creating cues to make and break habits [1:40:00]; • Law #2: Make it attractive—examples of ways to make a new behavior more attractive [1:48:00]; • Law #3: Make it easy—the 2-minute rule [1:59:00]; • Law #4: Make it satisfying—rewards and reinforcement [2:03:45]; • Advice for helping others to make behavioral changes [2:06:15]; and • More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
378
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2T 19M
#330 – Autism, ADHD, and Anxiety: Understanding the rise in autism and a multidisciplinary approach to diagnosis and treatment of each condition in children | Trenna Sutcliffe, M.D.View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter’s Weekly Newsletter Trenna Sutcliffe is a developmental behavioral pediatrician and the founder and medical director of the Sutcliffe Clinic in the San Francisco Bay Area, where she partners with families to provide care for children facing behavioral challenges, developmental differences, and school struggles. In this episode, Trenna shares her journey into developmental and behavioral pediatrics, including her pioneering work at Stanford and her expertise in autism, ADHD, and anxiety—the "three As." She explores the diagnostic processes, the overlap and comorbidities of these conditions, and the importance of personalized treatment plans that address both medical and environmental factors. Trenna offers valuable insights into the changing prevalence of autism, the impact of evolving diagnostic criteria, and the range of therapies and medications available to support children and their families. She also discusses the challenges in accessing care and the critical need for a holistic approach that bridges healthcare and education. We discuss: • Trenna’s passion for developmental-behavioral pediatrics (DBP), and the process of diagnosing anxiety, ADHD, and autism [3:15]; • Understanding anxiety and ADHD: assessing impairment and self-esteem and identifying anxiety and emotional well-being in young patients [9:45]; • The evolving diagnosis of autism: understanding the spectrum and individual needs [16:30]; • The dramatic rise in autism spectrum disorder (ASD): genetics, environment, expanded diagnostic criteria, and more [25:45]; • Exploring epigenetics and the potential multigenerational impact of environment exposures on susceptibility to certain disorders [37:15]; • The evolution of autism classifications, and the particular challenges for children with level 1 (mild) autism due to a lack of support [41:15]; • The broadening of the autism spectrum: benefits and risks of expanded diagnostic criteria and the need for future frameworks to focus on better outcomes [48:00]; • The overlap between ASD, ADHD, and anxiety [57:15]; • Understanding oppositional defiant disorder, and the importance of understanding the “why” behind a behavior when creating treatment plans [1:00:45]; • Defining developmental-behavioral pediatrics (DBP), and Trenna’s professional journey [1:07:00]; • Updated methods of ABA (applied behavioral analysis) therapy: evolution, controversies, challenges of scaling autism care, and the need for tailored interventions [1:13:45]; • Advice for parents trying to find and evaluate care for children with autism, ADHD, or anxiety [1:22:45]; Tailored treatments for ADHD: balancing stimulant medications with behavioral training [1:28:30]; • The interplay between medication, behavioral therapy, and neuroplasticity in managing ADHD, and the potential to grow out of the need for medication [1:39:45]; • Using medication to treat anxiety and other symptoms in kids with autism without ADHD [1:44:45]; • FAQs about medicating children with ADHD: benefits, side effects, dosage, and more [1:46:30]; • The “superpowers” associated with level 1 autism [1:48:45]; • The next steps to increase support for children with ASD, anxiety, and ADHD [1:50:45]; and • More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
379
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1T 57M
#332 - AMA #67: Microplastics, PFAS, and phthalates: understanding health risks and a framework for minimizing exposure and mitigating riskView the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter’s Weekly Newsletter In this “Ask Me Anything” (AMA) episode, Peter tackles a topic that's been dominating headlines and sparking widespread concern: microplastics and plastic-associated chemicals, including BPA, PFAS, and phthalates. Peter explores the science behind these substances including how and why they've become so prevalent, the extent of our exposure, and the potential risks to our health. Most importantly, he provides a practical framework for understanding microplastics and plastic-associated chemicals and minimizing exposure while distinguishing genuine risks from exaggerated concerns. If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #67 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here. We discuss: • The complexity of the topic of microplastics and associated chemicals [1:30]; • Definitions: microplastics, BPA, PM2.5, phthalates, and more [6:30]; • The reasons behind the increase in microplastics in our environment and the surge in interest in them [12:00]; • The various ways that humans are exposed to microplastics and nanoplastics [14:00]; • Volume of plastic consumed by humans, and how the body eliminates or absorbs microplastics [16:00]; • How microplastics accumulate in the body, the variability in tissue accumulation, and the challenges in studying their long-term health effects [21:30]; • Limitations of blood tests for microplastics, and the importance of reliable biomarkers for guiding behavior and interventions [26:30]; • The speculative health risks of microplastics, the limitations of current research, and the need for more robust studies [29:15]; • The challenges of measuring microplastics in human tissues, the need for better methodologies, and the importance of critically evaluating study relevance and claims [39:45]; • If it’s unclear whether microplastics actually cause harm, should we still be concerned about exposure? [42:15]; • Strategies to minimize microplastic exposure [45:00]; • The financial cost and effort involved in various microplastic exposure mitigation strategies [51:00]; • The role of airborne microplastics in total exposure and accumulation [1:03:00]; • Chemicals associated with plastics, their role as endocrine disruptors, and the challenges in linking exposure to specific health outcomes [1:04:00]; • BPAs: role in plastic production, and its potential developmental risks [1:05:45]; • BPA's potential health risks: pregnancy, fertility, obesity, and diabetes, and the socioeconomic confounders in the data [1:08:30]; • Regulatory limits on BPA exposure, and practical considerations for reducing exposure [1:12:45]; • The prevalence of BPA in modern products and how to identify it [1:17:15]; PFAS: chemical structure and purpose in products [1:18:30]; • Why PFAS are considered endocrine disruptors [1:19:45]; • The main sources of PFAS exposure, and practical steps to reduce exposure [1:21:30]; • The potential health risks of PFAS exposure [1:24:00]; • Phthalates: role in making plastics flexible and presence in personal care products [1:24:45]; • Why phthalates are considered endocrine disruptors [1:25:15]; • The main sources of phthalate exposure, and how manufacturing practices are evolving to reduce exposure [1:26:45]; • Practical strategies to reduce exposure to phthalates in food, air, water, and personal care products [1:28:30]; • Navigating microplastics and associated chemicals: a framework for personalized risk reduction [1:29:30]; and • More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
381
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25M
#333 ‒ Longevity roundtable — the science of aging, geroprotective molecules, lifestyle interventions, challenges in research, and more | Steven Austad, Matt Kaeberlein, Richard MillerView the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter’s Weekly Newsletter In this special episode of The Drive, Peter introduces a brand-new roundtable format. Joined by three renowned experts in longevity science—Steven Austad, Richard Miller, and Matt Kaeberlein—the group explores the rapidly evolving field of geroscience. Together, they dive deep into topics like the relationship between healthspan and lifespan, evaluating interventions like rapamycin and senolytics, the role of epigenetic changes in aging, and whether GLP-1 receptor agonists hold geroprotective potential. They also tackle major challenges in funding and public acceptance of longevity research including how geroprotective interventions might be tested in humans. Packed with nuanced debate, humor, and groundbreaking insights, this episode is a must-listen for anyone fascinated by the science of aging. We discuss: • The recent rise in public interest in longevity, misconceptions, and the link between healthspan and lifespan [3:45]; • Redefining healthspan, the US healthcare paradox, and separating longevity science from commercial hype [12:30]; • The need to redirect medical research from disease-specific models to aging-focused approaches [21:30]; • Proactive healthcare: rethinking health, disease, and the role of aging [30:00]; • Biologic age versus chronologic age, and the limitations and potential of epigenetic clocks [35:00]; • The utility and drawbacks of the “hallmarks of aging” as a framework for research and funding [49:30]; • The role of epigenetic changes in aging and the challenges of proving causality [56:45]; • The translational challenges of moving aging research from preclinical studies to human applications [1:03:45]; • Distinguishing between a biomarker of aging and aging rate indicators [1:17:15]; • The difficulties of translating longevity research in mice to humans, and the difficulties of testing interventions in humans [1:21:15]; • Exercise, aging, and healthspan: does exercise slow aging? [1:35:45]; • Are GLP-1 receptor agonists geroprotective beyond caloric restriction effects? [1:41:00]; • The role of senescent cells in aging, challenges with reproducibility in studies, and differing views on the value of current research approaches [1:46:15]; • How funding challenges and leadership in NIH and other institutes impact the advancement of aging-related research [2:00:15]; • Metformin: geroprotective potential, mechanisms, and unanswered questions [2:02:30]; • Canagliflozin and rapamycin as geroprotective molecules: mechanisms, dosing strategies, and longevity potential [2:10:45]; • Resveratrol and NAD precursors—a lack of evidence for anti-aging effects [2:22:45]; • The potential of parabiosis and plasmapheresis to slow aging, the challenges in translating mouse studies to humans, and possible design for human studies [2:29:45]; and • More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
382
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2T 41M

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