#02 - Rhonda Patrick, Ph.D.: the performance and longevity paradox of IGF-1, ketogenic diets and genetics, the health benefits of sauna, NAD+, and moreMD
#07 - Deep Dive: Lp(a) — what every doctor, and the 10-20% of the population at risk, needs to knowMD
#08 - Tom Bilyeu: nutrition, fasting, meditation, mindset, immortality, and the secret formula of fulfillmentMD
#09 - David Sabatini, M.D., Ph.D.: rapamycin and the discovery of mTOR — the nexus of aging and longevity?MD
#10 - Matt Kaeberlein, Ph.D.: rapamycin and dogs — man’s best friends? — living longer, healthier lives and turning back the clock on aging, and age-related diseasesMD
#11 - AMA #2: the Nothingburger — results from Peter’s week-long fast between two weeks of nutritional ketosis — and answering questions on all things fastingMD
#12 - Corey McCarthy: Overcoming trauma, dealing with shame, finding meaning, changing the self-narrative, redemption, and the importance of gratitudeMD
#16 - Formula 1 (with Paul Conti): the best drivers, Ayrton Senna, and the cautionary tales of driven individualsMD
#17 - Mike Trevino: life-lessons from ultra-endurance, mindset, hard work, and removing limitationsMD
#21 - Tom Dayspring, M.D., FACP, FNLA – Part II of V: Lipid metrics, lipid measurements, and cholesterol regulationMD
#22 - Tom Dayspring, M.D., FACP, FNLA – Part III of V: HDL, reverse cholesterol transport, CETP inhibitors, and apolipoproteinsMD
#23 - Tom Dayspring, M.D., FACP, FNLA – Part IV of V: Statins, ezetimibe, PCSK9 inhibitors, niacin, cholesterol and the brainMD
#24 - Tom Dayspring, M.D., FACP, FNLA – Part V of V: Lp(a), inflammation, oxLDL, remnants, and moreMD
#28 - Mark and Chris Bell: steroids, powerlifting, addiction, diet, training, helping others, documentaries, and living your best lifeMD
#29 - Apolo Anton Ohno: 8-time Olympic medalist – extreme training, discipline, pursuing perfection, and responding to adversityMD
#30 - Thomas Seyfried, Ph.D.: Controversial discussion—cancer as a mitochondrial metabolic disease?MD
#32 - Siddhartha Mukherjee, M.D., Ph.D.: new frontiers in cancer therapy, medicine, and the writing processMD
#38 - Francisco Gonzalez-Lima, Ph.D.: Advancing Alzheimer’s disease treatment and prevention – is AD actually a vascular and metabolic disease?MD
#40 - Tom Catena, M.D.: The world’s most important doctor – to nearly a million patients – saving countless lives in the war-torn and remote villages of SudanMD
#41 - Jake Kushner, M.D.: How to thrive with type 1 diabetes and how everyone can benefit from the valuable insightsMD
#42 - Avrum Bluming, M.D., and Carol Tavris, Ph.D.: Controversial topic affecting all women—the role of hormone replacement therapy through menopause and beyond—the compelling case for long-term HRT and dispelling the myth that it causes breast cancerMD
#43 - Alan Bauman, M.D.: The science of male and female hair restoration - how to protect, enhance, and restore the appearance and health of the hair and scalpMD
#46 - Chris Masterjohn, Ph.D.: Navigating the many pathways to health and disease - NAD and sirtuins, methylation, MTHFR and COMT, choline deficiency and NAFLD, TMAO, creatine, and moreMD
#47 – Matthew Walker, Ph.D., on sleep – Part I of III: Dangers of poor sleep, Alzheimer's risk, mental health, memory consolidation, and more.MD
#48 – Matthew Walker, Ph.D., on sleep – Part II of III: Heart disease, cancer, sexual function, and the causes of sleep disruption (and tips to correct it)MD
#49 – Matthew Walker, Ph.D., on sleep – Part III of III: The penetrating effects of poor sleep from metabolism to performance to genetics, and the impact of caffeine, alcohol, THC, and CBD on sleepMD
The Ayrton Senna Episode (re-release): Celebrating the greatest driver in Formula 1 history and the cautionary tales of driven individualsMD
#52 - Ethan Weiss, M.D.: A masterclass in cardiovascular disease and growth hormone - two topics that are surprising interrelatedMD
#53 - AMA #6: Fasting framework, vitamin supplementation, antioxidants, time management, problem-solving, and moreMD
#54 – Kevin Sayer, CEO of Dexcom: Continuous glucose monitors – impact of food, sleep, and stress on glucose, the unmatched power of CGM to drive behavioral change, and the exciting future of CGMMD
#55 - Jocko Willink, retired Navy SEAL, Part I of II: objective, strategy & tactics, leadership, protocols, dealing with death, and applying the many lessons learned from warMD
#56 - Jocko Willink, retired Navy SEAL, Part II of II: Sleep, fasting, raising kids, discipline, taking ownership, and the impact of warMD
#57 – Rick Rubin, legendary music producer: collaborating with sensitive psyche of greatest living musicians, and his personal story of weight loss and spiritual questMD
#58 – AMA with sleep expert, Matthew Walker, Ph.D.: Strategies for sleeping more, sleeping better, and avoiding things that are disrupting sleepMD
#60 - Annie Duke, decision strategist: Poker as a model system for life—how to improve decision making, use frameworks for learning, and apply ‘backcasting’ to boost your odds for future successMD
#59 - Jason Fung, M.D.: Fasting as a potent antidote to obesity, insulin resistance, type 2 diabetes, and the many symptoms of metabolic illnessMD
The one-year anniversary episode with Olivia Attia: Reflecting on the past year and looking forward to exciting times aheadMD
#61 - Rajpaul Attariwala, M.D., Ph.D.: Cancer screening with full-body MRI scans and a seminar on the field of radiologyMD
#62 - Keith Flaherty, M.D.: Deep dive into cancer—History of oncology, novel approaches to treatment, and the exciting and hopeful futureMD
#63 - AMA #7: Exercise framework, deadlifting, lower back pain, blood pressure, nootropics, CGM, and moreMD
#64 - Zol Kryger, M.D.: Navigating the sometimes shady world of plastic surgery—understanding potential complications of common procedures and how to reduce your risk by choosing the right doctor and asking the right questionsMD
#65 - Rick Doblin, Ph.D.: MDMA— the creation, scheduling, toxicity, therapeutic use, and changing public opinion of what is possibly the single most important synthetic molecule ever created by our speciesMD
#66 - Vamsi Mootha, M.D.: Aging, type 2 diabetes, cancer, Alzheimer’s disease, and Parkinson’s disease – do all roads lead to mitochondria?MD
#68 - Marty Makary, M.D.: The US healthcare system—why it’s broken, steps to fix it, and how to protect yourselfMD
#69 - Ronesh Sinha, M.D.: Insights into the manifestation of metabolic disease in a patient population predisposed to metabolic syndrome, and what it teaches us more broadlyMD
#70 - David Sinclair, Ph.D.: How cellular reprogramming could slow our aging clock (and the latest research on NAD)MD
#73 - AMA #9: NAD & metformin, fat-burning zone, creatine, estrogenization of men, emergency kit for cold & flu, and moreMD
Qualy #33 - How silent bravado and incessant striving can lead to a functional (and actual) death, and why Paul is critical of the current state of psychiatryMD
#77 – AMA #2 with sleep expert, Matthew Walker, Ph.D.: short sleep mutants, optimal sleep environment, sleep apnea, & rapid fire questionsMD
Qualy #57 - A primer on NAD+/NADH, its effect on lifespan/healthspan, and a review of the supplementsMD
Qualy #65 - The three laws of medicine — Law #1: A strong intuition is much more powerful than a weak testMD
Qualy #69 - Advice to parents and kids for creating a sustainable environment that’s going to prevent them from running into metabolic problemsMD
Qualy #73 - How can we change the food system when 10 companies control almost 90 percent of the calories we consume in the US?MD
Qualy #80 - The four pillars of charity: water that helped it overcome the stigma of nonprofits and become successfulMD
#87 - Rick Johnson, M.D.: Fructose—The common link in high blood pressure, insulin resistance, T2D, & obesity?MD
Qualy #102 - Is the food industry still saying that all calories contribute equally to adiposity and insulin resistance?MD
#93 - AMA with Jason Fried: Work-life balance, avoiding burnout, defining success, company culture, and moreMD
#95 - Luke Bennett, M.D.: The emotional, cognitive, and physical demands that make Formula 1 a unique and special sportMD
#96 - David Epstein: How a range of experience leads to better performance in a highly specialized worldMD
#97 - Peter Hotez, M.D., Ph.D.: COVID-19: transmissibility, vaccines, risk reduction, and treatmentMD
#102 - Michael Osterholm, Ph.D.: COVID-19—Lessons learned, challenges ahead, and reasons for optimism and concernMD
#105 - Paul Conti, M.D.: The psychological toll of a pandemic, and the societal problems it has highlightedMD
#106 - Amesh Adalja, M.D.: Comparing COVID-19 to past pandemics, preparing for the future, and reasons for optimismMD
#115 - David Watkins, Ph.D.: A masterclass in immunology, monoclonal antibodies, and vaccine strategies for COVID-19MD
#116 - AMA with Dom D’Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exerciseMD
#120 - AMA with Dom D’Agostino, Ph.D., Part II of II: Ketosis for cancer and chronic disease, hyperbaric oxygen therapy, and the effect of ketosis on female healthMD
#122 - Lori Gottlieb: Understanding pain, therapeutic breakthroughs, and keys to enduring emotional healthMD
#123 - Joan Mannick, M.D. & Nir Barzilai, M.D.: Rapamycin and metformin—longevity, immune enhancement, and COVID-19MD
#124 - AMA #15: Real-world case studies—metabolic dysregulation, low testosterone, menopause, and moreMD
#126 – Matthew Walker, Ph.D.: Sleep and immune function, chronotypes, hygiene tips, and addressing questions about his bookMD
#127 - AMA #3 with sleep expert, Matthew Walker, Ph.D.: Fasting, gut health, blue light, caffeine, REM sleep, and moreMD
#130 - Carol Tavris, Ph.D. & Elliot Aronson, Ph.D.: Recognizing and overcoming cognitive dissonanceMD
#131 - Beth Lewis: The Art of Stability: Learning about pain, mitigating injury, and moving better through lifeMD
#138 - Lauren Miller Rogen and Richard Isaacson, M.D.: Alzheimer’s disease prevention—patient and doctor perspectivesMD
#140 - Gerald Shulman, M.D., Ph.D.: A masterclass on insulin resistance—molecular mechanisms and clinical implicationsMD
#142 - Robert Abbott: The Bobby Knight story—a cautionary tale of unchecked anger, ego, and winning at all costsMD
#145 - AMA #19: Deep dive on Zone 2 training, magnesium supplementation, and how to engage with your doctorMD
#147 - Hussein Yassine, M.D.: Deep dive into the “Alzheimer’s gene” (APOE), brain health, and omega-3sMD
#148 - Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the Interventions Testing ProgramMD
#149 - AMA #20: Simplifying the complexities of insulin resistance: how it's measured, how it manifests in the muscle and liver, and what we can do about itMD
#150 - Senator Bill Frist, M.D.: A modern Renaissance man's journey through science, politics, and businessMD
#154 - Steve Levitt, Ph.D.: A rogue economist’s view on climate change, mental health, the ethics of experiments, and moreMD
#156 - Jake Muise: Humanely harvesting axis deer while alleviating its impact on Hawaii’s vulnerable ecosystemsMD
#158 - Brian Deer: A tale of scientific fraud—exposing Andrew Wakefield and the origin of the belief that vaccines cause autismMD
#159 - Peter Hotez, M.D., Ph.D.: Evolution of the anti-vaccine movement, the causes of autism, and COVID-19 vaccine state of affairsMD
#160 - Paul Offit, M.D.: The latest on COVID-19 vaccines and their safety, herd immunity, and viral variantsMD
#161 - AMA #23: All Things Nicotine: deep dive into its cognitive and physical benefits, risks, and mechanisms of actionMD
#162 - Sarah Hallberg, D.O., M.S.: Challenging the status quo of treating metabolic disease, and a personal journey through a grim cancer diagnosisMD
#164 - Amanda Smith, M.D.: Diagnosing, preventing, and treating Alzheimer’s disease, and what we can all learn from patients with dementiaMD
#165 - AMA #24: Deep dive into blood glucose: why it matters, important metrics to track, and superior insights from a CGMMD
#166 - Patricia Corby, D.D.S.: Importance of oral health, best hygiene practices, and the relationship between poor oral health and systemic diseaseMD
#168 - Hugh Jackman: Reflections on acting, identity, personal transformation, and the significance of being WolverineMD
#169 - Katherine Eban: COVID-19 Lab Leak: Examining all sides of the debate and discussing barriers to a full investigationMD
#171 - Steve Austad, Ph.D.: The landscape of longevity science: making sense of caloric restriction, biomarkers of aging, and possible geroprotective moleculesMD
#172 - Esther Perel: The effects of trauma, the role of narratives in shaping our worldview, and why we need to accept uncomfortable emotionsMD
#174 - Lawrence Wright: The 20th anniversary of the 9/11 attacks: reflections on how they happened, and lessons learned and not learnedMD
#175 - Matt Kaeberlein, Ph.D.: The biology of aging, rapamycin, and other interventions that target the aging processMD
#176 - AMA #27: The importance of muscle mass, strength, and cardiorespiratory fitness for longevityMD
#177 - Steven Rosenberg, M.D., Ph.D.: The development of cancer immunotherapy and its promise for treating advanced cancersMD
#179 - Jeremy Loenneke, Ph.D.: The science of blood flow restriction—benefits, uses, and what it teaches us about the relationship between muscle size and strengthMD
#181 - Robert Gatenby, M.D.: Viewing cancer through an evolutionary lens and why this offers a radically different approach to treatmentMD
#185 - Allan Sniderman, M.D.: Cardiovascular disease and why we should change the way we assess riskMD
#186 - Patrick Radden Keefe: The opioid crisis—origin, guilty parties, and the difficult path forwardMD
#191 - Revolutionizing our understanding of mental illness with optogenetics | Karl Deisseroth M.D., Ph.D.MD
#202 - Peter on nutrition, disease prevention, sleep, and more — looking back on the last 100 episodesMD