In this episode, Thomas Seyfried, a cancer researcher and professor of biology at Boston College, discusses a controversial view of cancer as a mitochondrial metabolic disease. Many topics related to the causes, treatments, and prevention of cancer are covered in this in-depth conversation. We discuss: • How Tom got interested in cancer research [ 9:00 • ]; • Calorie-restricted ketogenic diets, fasting, and epileptic seizures [ 18:30 • ]; • Otto Warburg and the Warburg effect [30:45]; • Germline mutations, somatic mutations, and no mutations [42:00]; • Mitochondrial substrate level phosphorylation: Warburg’s missing link [51:30]; • What is the structural defect in the mitochondria in cancer? [ 1:02:00 • ]; • Peter’s near-death experience with the insulin suppression test while in ketosis [1:06:30]; • Insulin potentiation therapy and glutamine inhibition [1:13:15]; • The macrophage fusion-hybrid theory of metastasis [1:39:30]; • How are cancer cells growth dysregulated without a mutation? [ 1:47:00 • ]; • What is the dream clinical trial to test the hypothesis that we can reduce the death rates of cancer by 50%? [2:03:15]; • How can the hypothesis be tested rigorously that structural abnormalities in the mitochondria impair respiration and lead to compensatory fermentation? [2:26:30]; • Case studies of GBM survivors [2:32:45]; and • More. Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram.