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CoinDesk

Generation Crypto is focused on how brands and marketers are exploring and building in the Web3 ecosystem to experiment in and potentially transform their businesses. Each week, our hosts Avery Akkineni of Vayner 3 and Sam Ewen from CoinDesk, will dive into how Fortune 500 brands and new start-ups alike are coming to the blockchain and utilizing new technologies, the creator economy and rewriting fandom/ownership to generate attention, gain customers and create value for their bottom line and those of their communities.

Gen C

Cronos Labs CEO, Ryan Wyatt, reveals the roadmap to fix the "bad taste" crypto left for Gen Z by trading technical jargon for a mobile-first investment engine

Ryan Wyatt, CEO of Cronos Labs, joins Gen C to reveal why the biggest disruption for blockchain is no longer in gaming, but in a multi-trillion dollar financial overhaul. Ryan breaks down the strategy behind building a mobile-first app that strips away crypto jargon to onboard the 90% of Gen Z who have been "screwed" by traditional economic promises. 

- Links mentioned from the podcast:

 
Ryan's Twitter 

 Cronos Website

- Follow us on Twitter: 

 
⁠⁠⁠Sam Ewen⁠⁠⁠, ⁠⁠⁠CoinDesk⁠

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To attend or for more information on Consensus Miami 2026, visit: https://consensus.coindesk.com/.

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"Gen C" features host Sam Ewen. Executive produced by Uyen Truong.

How Ryan Wyatt is Rebuilding the Investment Experience for the Gen Z Audience

Avalanche CBO, John Nahas, reveals the roadmap to solve the $100 trillion institutional distribution problem by trading general purpose blockchains for custom L1s.

John Nahas, Chief Business Officer of Avalanche, joins Gen C to reveal the roadmap for transforming global finance through custom tailored, sovereign L1 blockchains. John breaks down the industry's much-needed transition away from "one-size-fits-all" technology to solve the $100 trillion distribution problem for institutions like JP Morgan and Citi. He shares the strategy behind Avalanche becoming the invisible backbone for everything from FIFA collections to tokenized equity markets, delivering the institutional rails required to move beyond speculative hype into real world economic value.

- Links mentioned from the podcast:

 
John's Twitter 

 Avalanche Website

 Ava Labs Website

 
New York Times Article: "Crypto is Pointless" 

- Follow us on Twitter: 

 
⁠⁠Sam Ewen⁠⁠, ⁠⁠CoinDesk

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"Gen C" features host Sam Ewen. Executive produced by Uyen Truong.

John Nahas on Why One-Size-Fits-All Blockchains are Failing Global Institutions

Sam Ewen breaks down the absence of crypto from the 2026 Super Bowl, comparing today’s silence to the frenzy of 2022.

Sam Ewen asks the question: where are all the 2026 Super Bowl ads? He explores the mystery of why crypto’s biggest players are sitting on the sidelines of the world's largest advertising event, even as "AI hyperscalers" and consumer staples take over the broadcast. 

NOTE: Recorded prior to the Super Bowl airing and yes, Coinbase did run a Super Bowl.

- Follow us on Twitter: 

 
⁠Sam Ewen⁠, ⁠CoinDesk⁠

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"Gen C" features host Sam Ewen. Executive produced by Uyen Truong.

Where Did All The Crypto Super Bowl Ads Go?

IOTA CMO, Karen O’Brien reveals the high-stakes roadmap to transform the $35 trillion global trade industry from archaic paper systems into a frictionless, blockchain-powered infrastructure.

Karen O’Brien, CMO of IOTA, breaks down why the industry is finally hitting a much-needed trust reset, trading short-term hype for the work of fixing global trade. O’Brien touches on how she’s helping solve the $35 trillion "paper and email" bottleneck to create an invisible backbone for global supply chains—a true blockchain for machines.

- Links mentioned from the podcast: 

 
Karen's Twitter 

 
IOTA Website

- Follow us on Twitter: 

 
Sam Ewen, CoinDesk

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"Gen C" features host Sam Ewen. Executive produced by Uyen Truong.

IOTA’s Karen O'Brien on The $35 Trillion Bet on Industrial Blockchain

From building Braintree to launching Blueprint, Bryan Johnson reveals how the systems architecture of FinTech and the philosophy of crypto are powering a new, autonomous roadmap to reverse human aging and operationalize immortality.

Founder and CEO of Blueprint and Don’t Die, Bryan Johnson, joins Gen C to discuss why the philosophy of crypto has the same mindset required to solve human aging. Bryan reveals how he is applying FinTech systems-thinking to the human body through "Autonomous Health" and bio-algorithms. We explore his journey to reverse his biological age and why the tech community is the primary driver of the next great evolution in human existence.

- Links mentioned from the podcast: 

 
Bryan's Twitter 

 
Blueprint Website

 
Don’t Die Website

- Follow us on Twitter: 

 
Sam Ewen, CoinDesk

- From our sponsor:

 
Check out CoinDesk's research report on KuCoin at: https://www.coindesk.com/research/kucoin-hits-record-market-share-as-2025-volumes-outpace-crypto-market

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"Gen C" features host Sam Ewen. Executive produced by Uyen Truong.

Building Autonomous Health Systems in the Age of AI with Bryan Johnson

OpenSea, CMO, Adam Hollander reveals the high-stakes roadmap to transform the world’s leading NFT marketplace into a frictionless, universal hub for the entire onchain economy.

From flipping digital land to becoming CMO for OpenSea, Adam Hollander shares his vision for the future of digital ownership. After surviving the NFT boom and bust, OpenSea is staging a major comeback by broadening its scope to every digital asset through a complete platform rebuild. He outlines a roadmap to transform OpenSea from a simple marketplace into a universal interface for the entire on-chain economy, abstracting away backend complexity to serve as the primary gateway for all digital culture and trade.

- Links mentioned from the podcast:

 
Adams's Twitter 

 
OpenSea Website

-Follow us on Twitter: 

 
Sam Ewen, CoinDesk

- From our sponsor:

 Check out CoinDesk's research report on GoPlus Security at: https://www.coindesk.com/research/protocol-research-goplus-security

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"Gen C" features host Sam Ewen. Executive produced by Uyen Truong.

OpenSea’s Vision for a Unified Onchain Home with Adam Hollander

Yorke Rhodes III, Co-Founder, Blockchain at Microsoft, reveals how Credible Neutrality and the convergence of AI agents and stablecoins are powering the next, decentralized wave of technological innovation.

Drawing on lessons from the early internet, Yorke Rhodes III, Co-Founder, Blockchain at Microsoft, explains why credible neutrality is vital to prevent the centralization of Web2 and emphasizes the urgent need for digital provenance in the age of synthetic media. He details how the convergence of AI agents and stablecoins creates instant liquidity and accelerates enterprise value, urging the industry to think bigger for the next generation.

- Links mentioned from the podcast: 

 
⁠Yorke's Twitter 

 
Microsoft Blockchain Website

-Follow us on Twitter:

 
⁠Sam Ewen⁠, ⁠CoinDesk⁠

-From our sponsors:

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 Need liquidity without selling your crypto? Take out a ⁠Figure Crypto-Backed Loan⁠, allowing you to borrow against your BTC, ETH, or SOL with 12-month terms and no prepayment penalties. They have the lowest rates in the industry at 8.91%, allowing you to access instant cash or buy more Bitcoin without triggering a tax event.Unlock your crypto’s potential today at Figure! ⁠https://figuremarkets.co/coindesk⁠

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"Gen C" features host Sam Ewen. Executive produced by Uyen Truong.

Yorke Rhodes on Why Credible Neutrality is the Safety Net

Dapper Labs Co-Founder & CEO, Roham Gharegozlou discusses the expansion of the Flow ecosystem into DeFi and how programmable assets and Agentic AI will power the next generation of tokenized creator economies.

Dapper Labs Co-Founder & CEO Roham Gharegozlou joins Gen C to discuss the evolution of digital collectibles and the next major wave of crypto adoption. He shares the strategy behind building the Flow blockchain, from NBA Top Shot’s success to onboarding millions of consumers, emphasizing economic alignment through their pivot to DeFi with Peak Money. He sees the future powered by stablecoins and Agentic AI, where every creator manages their own tokenized economy on platforms like Disney and TikTok.

- Links mentioned from the podcast: 

 
Roham's Twitter 

 Dapper Labs Website

 Flow Website

-Follow us on Twitter:

 
Sam Ewen, CoinDesk

-From our sponsors:

 Break the cycle of exploitation.

Break down the barriers to truth.

Break into the next generation of privacy.

Break Free.

Free to scroll without being monetized.

Free from censorship.

Freedom without fear.

We deserve more when it comes to privacy. Experience the next generation of blockchain that is private and inclusive by design.

Break free with Midnight, visit midnight.network/break-free

 Need liquidity without selling your crypto? Take out a Figure Crypto-Backed Loan, allowing you to borrow against your BTC, ETH, or SOL with 12-month terms and no prepayment penalties. They have the lowest rates in the industry at 8.91%, allowing you to access instant cash or buy more Bitcoin without triggering a tax event.Unlock your crypto’s potential today at Figure! https://figuremarkets.co/coindesk

-

"Gen C" features host Sam Ewen. Executive produced by Uyen Truong.

Roham Gharegozlou on Flow and Dapper Labs' Mission to Take DeFi Mainstream

Coinbase's CMO, Cat Ferdon, shares the strategy for moving beyond crypto natives, normalizing "internet money," and defining the future of finance through culturally resonant campaigns.

Joining Gen C, Coinbase CMO, Cat Ferdon shares the strategy behind marketing one of the world's most powerful crypto brands. Cat discusses why economic freedom is Coinbase's core mission, how the company is moving beyond the "crypto native" audience to onboard the next generation, and her plan to normalize "internet money" by delivering culturally resonant campaigns that define the next decade of global adoption.

- Links mentioned from the podcast:

 Cat's Twitter

 Coinbase Website

 Coinbase Brand Campaign - Everything Is Fine

- Follow us on Twitter

 
Sam Ewen, CoinDesk

- From our sponsors:

 
Break the cycle of exploitation.

Break down the barriers to truth.

Break into the next generation of privacy.

Break Free.

Free to scroll without being monetized.

Free from censorship.

Freedom without fear.

We deserve more when it comes to privacy. Experience the next generation of blockchain that is private and inclusive by design. Break free with Midnight, visit ⁠⁠midnight.network/break-free⁠⁠

 Need liquidity without selling your crypto? Take out a ⁠Figure Crypto-Backed Loan⁠, allowing you to borrow against your BTC, ETH, or SOL with 12-month terms and no prepayment penalties. They have the lowest rates in the industry at 8.91%, allowing you to access instant cash or buy more Bitcoin without triggering a tax event. Unlock your crypto’s potential today at Figure! ⁠https://figuremarkets.co/coindesk⁠

-

"Gen C" features host Sam Ewen. Executive produced by Uyen Truong.

From Cash App to Coinbase: Cat Ferdon on Marketing the Crypto Frontier

Circle's SVP of Marketing, Tim Queenan, shares why stablecoins and the new Arc blockchain are creating the ‘Economic OS for the internet.

Tim Queenan, SVP of Marketing, Circle, joins Gen C this week to share that stablecoins and programmable money represent a foundational shift in the global financial system, similar to the early internet. He discusses how Circle is spearheading this transformation with USDC and its new blockchain Arc, creating the ‘Economic OS for the internet

- Links mentioned from the podcast: 

 
Tim's Twitter 

 
Circle's Twitter

 
Circle Website

- Follow us on Twitter: 

 
⁠Sam Ewen⁠, ⁠CoinDesk⁠

-From our sponsors:

 
Break the cycle of exploitation.

Break down the barriers to truth.

Break into the next generation of privacy.

Break Free.

Free to scroll without being monetized.

Free from censorship.

Freedom without fear.

We deserve more when it comes to privacy. Experience the next generation of blockchain that is private and inclusive by design. Break free with Midnight, visit ⁠midnight.network/break-free⁠

 Genius Group has partnered with CoinDesk for Bitcoin Treasury Month, launching the Genius x CoinDesk Quest. Participants can join the Bitcoin Academy, complete free microcourses from experts like Natalie Brunell and Saifedean Ammous, and enter to win 1,000,000 GEMs (worth 1 BTC) promoting bitcoin education and adoption. CTA: ⁠geniusgroup.ai/coindesk-bitcoin-treasury-month/⁠

 Need liquidity without selling your crypto? Take out a Figure Crypto-Backed Loan, allowing you to borrow against your BTC, ETH, or SOL with 12-month terms and no prepayment penalties. They have the lowest rates in the industry at 8.91%, allowing you to access instant cash or buy more Bitcoin without triggering a tax event. Unlock your crypto’s potential today at Figure! https://figuremarkets.co/coindesk

-

"Gen C" features host Sam Ewen. Executive produced by Uyen Truong.

How Ryan Wyatt is Rebuilding the Investment Experience for the Gen Z Audience

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