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Medscape

This podcast delivers Dr. John Mandrola’s summary and perspective on top news of the week that cardiologists can’t miss. This podcast is intended for US health professionals only.

This Week in Cardiology

More trials at ESC, including PARACHUTE HF, DAPA ACT HF-TIMI 68, AMALFI, and a super-interesting modeling study of when to start oral anticoagulants in AF, are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I PARACHUTE HF
 
First Evidence of Treatment Benefit in Chagas Heart Failure
 
 https://www.medscape.com/viewarticle/first-evidence-treatment-benefit-chagas-heart-failure-2025a1000oem
 
 PARACHUTE-HF https://www.jacc.org/doi/10.1016/j.jchf.2024.05.021 
II SGLT2i Early Initiation — DAPA ACT HF-TIMI 68 Trial
 
Trial Data Support In-Hospital Initiation of SGLT2 Inhibitors for Heart Failure https://www.medscape.com/viewarticle/trial-data-support-hospital-initiation-sglt2-inhibitors-2025a1000o5q
 
 DAPA ACT HF-TIMI 68 
 https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.076575
 
III AMALFI Trial of AF Screening
 
Remote ECG Screening Ups Atrial Fibrillation Detection ‘Modestly’ https://www.medscape.com/viewarticle/remote-ecg-screening-ups-atrial-fibrillation-detection-2025a1000myx
 
 AMALFI Trial https://jamanetwork.com/journals/jama/article-abstract/2838482 STROKESTOP Trial https://www.thelancet.com/article/S0140-6736(21)01637-8/fulltext LOOP Trial 10.1016/S0140-6736(21)01698-6 External Link 
IV Finding that Sweet Spot of Stroke Risk Threshold for Starting DOAC therapy
 
 Stroke Risk Threshold for non-Vitamin K Antagonist OAC in AF • 
https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.125.012090 Variations in Rates of Stroke Across Patients With AF • 
https://www.ahajournals.org/doi/10.1161/circulationaha.116.024057 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Sep 19 2025 This Week in Cardiology

More from ESC including: Valvular HD guidelines, a new drug class for HTN, myosin inhibition in HCM, vericiguat, and digoxin are the topic discussed by John Mandrola, MD.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I New European Valvular Heart Disease Guidelines
 
 • 2025 ESC/EACTS Guidelines for the management of valvular heart disease https://doi.org/10.1093/eurheartj/ehaf194
 • Debate: Does Asymptomatic Aortic Stenosis Warrant Early Intervention? https://exp.medscape.com/debates/does-asymptomatic-aortic-stenosis-warrant-early-intervention/
 • Surgical Ablation of Atrial Fibrillation during Mitral-Valve Surgery https://www.nejm.org/doi/full/10.1056/NEJMoa1500528
 • Surgical ablation of atrial fibrillation: a systematic review and meta-analysis https://doi.org/10.1093/europace/eux336
 
II New Drug for Resistant HTN
 
 • Baxdrostat: A 'Game Changer' for Hypertension? https://www.medscape.com/viewarticle/baxdrostat-game-changer-hypertension-2025a1000mz7
 • Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension https://www.nejm.org/doi/full/10.1056/NEJMoa2507109
 • Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension https://www.nejm.org/doi/10.1056/NEJMoa2501440
 
III HCM News at ESC
 
 • New Trials Clarify Role of Myosin Inhibitors for Hypertrophic Cardiomyopathy https://www.medscape.com/viewarticle/new-trials-clarify-role-myosin-inhibitors-hypertrophic-2025a1000myv
 • MAPLE HCM https://www.nejm.org/doi/full/10.1056/NEJMoa2504654
 • SEQUOIA HCM https://www.nejm.org/doi/10.1056/NEJMoa2401424
 • ODYSSEY HCM https://www.nejm.org/doi/full/10.1056/NEJMoa2505927
 
IV Vericiguat at ESC
 
 • New Data Said to Support Vericiguat as Standard Therapy for Heart Failurehttps://www.medscape.com/viewarticle/new-data-said-support-vericiguat-standard-therapy-heart-2025a1000mz9
 • VICTOR https://doi.org/10.1016/S0140-6736(25)01665-4
 • VICTORIA https://www.nejm.org/doi/full/10.1056/NEJMoa1915928
 • An individual participant data analysis of the VICTORIA and VICTOR trials https://doi.org/10.1016/S0140-6736(25)01682-4
 
V More on Digoxin
 
 • RATE AF substudy https://doi.org/10.1002/ejhf.70022
 • Main RATE-AF trial https://jamanetwork.com/journals/jama/fullarticle/2774407
 • Efficacy of β blockers in patients with heart failure plus atrial fibrillation: an individual-patient data meta-analysis https://doi.org/10.1016/S0140-6736(14)61373-8
 
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Sep 12 2025 This Week in Cardiology

The big beta-blocker story from ESC, dual pathway therapy with aspirin and OAC, stopping OAC after successful AF ablation, and DANCAVAS II trial are the topics John Mandrola, MD, discusses on this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Listener Feedback
 
This Week in Cardiology Podcast – August 29 https://www.medscape.com/viewarticle/1002877
 
II The Big Beta-blocker Story from ESC
 
Beta-Blockers Post-MI: A Clear Clinical Message https://www.medscape.com/viewarticle/beta-blockers-post-mi-clear-clinical-message-2025a1000mz0
 
 REBOOT https://www.nejm.org/doi/full/10.1056/NEJMoa2504735 BETAMI-DANBLOCK https://www.nejm.org/doi/abs/10.1056/NEJMoa2505985 REDUCE AMI https://www.nejm.org/doi/10.1056/NEJMoa2401479 CAPITAL RCT https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199347 Post Hoc Analysis From REBOOT Trial https://eurointervention.pcronline.com/article/effect-of-beta-blocker-withholding-or-withdrawal-after-myocardial-infarction-without-reduced-ejection-fraction-on-ischaemic-events-a-post-hoc-analysis-from-the-reboot-trial Beta-Blockers After MI With Mildly Reduced Ejection Fraction https://doi.org/10.1016/S0140-6736(25)01592-2 CAPRICORN 10.1016/S0140-6736(00)04560-8 External Link BHAT https://jamanetwork.com/journals/jama/fullarticle/370103 ISIS 1 https://pubmed.ncbi.nlm.nih.gov/2873379/ 
III Aspirin and OAC Combination Clearly Dangerous
 
Aspirin Plus Oral Anticoagulants Raises Mortality, Bleeding https://www.medscape.com/viewarticle/aspirin-plus-oral-anticoagulants-raises-mortality-bleeding-2025a1000nam
 
 AQUATIC https://www.nejm.org/doi/full/10.1056/NEJMoa2507532 AFIRE https://www.nejm.org/doi/full/10.1056/NEJMoa1904143 EPIC CAD https://www.nejm.org/doi/10.1056/NEJMoa2407362 OAC-ALONE https://pubmed.ncbi.nlm.nih.gov/30586700/ 
IV Stop or Continue OAC after Successful AF Ablation
 
 ALONE-AF https://jamanetwork.com/journals/jama/fullarticle/2838294 OCEAN trial protocol https://doi.org/10.1016/j.ahj.2017.12.007 
V DANCAVAS II Trial
 
 DANCAVAS II https://doi.org/10.1093/eurheartj/ehaf704 DANCAVAS I https://www.nejm.org/doi/full/10.1056/NEJMoa2208681 
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Questions or feedback, please contact news@medscape.net

Sep 05 2025 This Week in Cardiology

CAC 0 takes a gut punch, ICD therapies cannot be surrogates for benefit, and two important trials from ESC are the topics John Mandrola, MD, discusses in this week’s podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I CAC 0
 
 LDL-C and CVD Risk With CAC Score 0 https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaf497/8228645 
II ICD Therapies
 
 Contemporary ICD Benefit https://www.jacc.org/doi/10.1016/j.jacep.2025.06.028 PROFID Trial https://profid-project.eu/profid-ehra-trial/ MADIT-RIT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1211107 Declining Risk of Sudden Death in HF https://www.nejm.org/doi/full/10.1056/NEJMoa1609758 
III Digit-HF
 
 DIGIT-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2415471 Digoxin–Mortality: Comparison in the DIG trial https://academic.oup.com/eurheartj/article/40/40/3336/5520008 
IV POTCAST
 
 POTCAST trial https://www.nejm.org/doi/full/10.1056/NEJMoa2509542 
ESC Preview
 
IV HTN Guidelines
 
 New Blood Pressure Guidelines: 4 Things I Like and 2 Concerns https://www.medscape.com/viewarticle/new-blood-pressure-guidelines-4-thing-i-and-2-concerns-2025a1000m1x 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Aug 29 2025 This Week in Cardiology

John Mandrola discusses conduction system pacing vs standard pacing, withdrawing HF meds when AF is corrected and patient selection in LAAO.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Conduction System Pacing
 
 • CSPACE trial https://doi.org/10.1016/j.jacc.2025.06.043
 • BLOCK HF trial https://www.nejm.org/doi/full/10.1056/NEJMoa1210356
 • BioPace trial https://doi.org/10.1093/europace/euaf029
 
II Withdrawing Meds After AF Corrected
 
 • WITHDRAW AF https://doi.org/10.1093/eurheartj/ehaf563
 • TRED HF https://pubmed.ncbi.nlm.nih.gov/30429050/
 
III Patient Selection in Left Atrial Appendage Occlusion
 
 • Long-Term Outcomes Following LAAO in Medicare Beneficiaries: Outcomes From the National Cardiovascular Data Registry https://www.ahajournals.org/doi/10.1161/JAHA.124.039780
 
ESC Preview
 
IV HTN Guidelines
 
 • New Blood Pressure Guidelines: 4 Things I Like and 2 Concerns https://www.medscape.com/viewarticle/new-blood-pressure-guidelines-4-thing-i-and-2-concerns-2025a1000m1x
 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Aug 22 2025 This Week in Cardiology

Big new hypertension guidelines, ultraprocessed foods, coronary sinus reduction and evidence-based medicine, and more news on pulsed field ablation for atrial fibrillation are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I HTN Guidelines
 
 BP Meds Should Begin Promptly, New ACC/AHA Guidelines Say 
 https://www.medscape.com/viewarticle/bp-meds-should-begin-promptly-new-acc-aha-guidelines-say-2025a1000lms
 
 Guideline for Management of High Blood Pressure https://www.ahajournals.org/doi/10.1161/CIR.0000000000001356 BPROAD trial https://www.nejm.org/doi/full/10.1056/NEJMoa2412006 Trial Score Framework https://pmc.ncbi.nlm.nih.gov/articles/PMC6459598/ 
II UltraProcessed Foods
 
 AHA statement on Ultraprocessed Foods and Cardiometabolic Health • 
https://www.ahajournals.org/doi/full/10.1161/CIR.0000000000001365 
III Refractory Angina and the Coronary Sinus Reducer – A Lesson in EBM
 
 Coronary Sinus Reducer Shows Promise, With Caveats https://www.medscape.com/viewarticle/coronary-sinus-reducer-shows-promise-caveats-2025a1000l76 Coronary Sinus Reducer — Meta-analysis https://www.jacc.org/doi/10.1016/j.jcin.2025.06.012 COSIRA II Trial https://clinicaltrials.gov/study/NCT05102019 
IV Pulsed Field Ablation Still Looking Strong
 
 Management of OACs After PFA 10.1016/j.hrthm.2025.03.1952 External Link 
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Aug 15 2025 This Week in Cardiology

Listener feedback on SURPASS CVOT, AF ablation and the limits of meta-analyses, a Watchman alert from FDA, and oral anticoagulation choices in elderly patients are discussed by John Mandola, MD, in this week’s podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I SURPASS CVOT
 
 This Week in Cardiology Podcast, August 1 https://www.medscape.com/viewarticle/1002781 Mounjaro Appears More Heart Protective Than Trulicity in Trial Of Eli Lilly Diabetes Drugs 
 https://www.medscape.com/s/viewarticle/mounjaro-proves-more-heart-protective-than-trulicity-trial-2025a1000kct
 
II Catheter and Surgical AF ablation
 
 Catheter and Surgical Ablation for AF: Meta-Analysis https://www.acpjournals.org/doi/10.7326/ANNALS-25-00253 
III Watchman Air Embolism Alerts
 
 Looming Pay Cut to LAAO Triggers Objection From Card Groups 
 https://www.medscape.com/viewarticle/looming-pay-cut-laao-triggers-objection-card-groups-2025a1000l0j
 
 FDA Alert https://www.fda.gov/medical-devices/medical-device-recalls/early-alert-watchman-access-system-issue-boston-scientific 
IV Switching Oral Anticoagulants in Frail Older Adults Patients
 
 FRAIL AF Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.066485 COMBINE AF Substudy https://doi.org/10.1016/j.jacc.2025.05.060 The Most Important Study From ESC: FRAIL-AF https://www.medscape.com/viewarticle/996063 
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Questions or feedback, please contact news@medscape.net

Aug 08 2025 This Week in Cardiology

Exercise and CV outcomes, aldosterone modulation, AI for ECG reading, GLP-1 comparisons, end-of-life decisions, and another well-meaning policy that caused harm in veterans are discussed by John Mandrola, MD, in this week’s podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Exercise and CV outcomes
 
II Aldosterone Modulation in Cardio-Kidney Disease
 
 Aldosterone and Aldosterone Modulation https://doi.org/10.1016/j.jacc.2025.06.012 Randomized Aldactone Evaluation Study https://www.nejm.org/doi/full/10.1056/NEJM199909023411001 
III AI vs MD ECG-Reading for Cath Lab Activation
 
 Accuracy of Cath Lab Activation Decisions https://doi.org/10.1016/j.ajem.2025.07.061 
IV Tirzepatide vs Dulaglutide - SURPASS CVOT Study
 
 Eli Lilly Press Release https://investor.lilly.com/news-releases/news-release-details/lillys-mounjaro-tirzepatide-gipglp-1-dual-agonist-demonstrated REWIND Study 10.1016/S0140-6736(19)31149-3 External Link 
V End-of-Life Decisions
 
Doctors’ Own End-of-Life Choices Defy Common Medical Practice
 
 https://www.medscape.com/viewarticle/doctors-own-end-life-choices-defy-common-medical-practice-2025a1000k01
 
 Physicians’ Preferences for Their Own End of Life https://jme.bmj.com/content/early/2025/06/05/jme-2024-110192 How US Doctors Die: A Cohort Study https://agsjournals.onlinelibrary.wiley.com/doi/full/10.1111/jgs.14112 
VI Well-Meaning Policies That Make Sense
 
 
 The Mission Act and Cardiovascular Procedures https://jamanetwork.com/journals/jama/fullarticle/2837067 
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Aug 01 2025 This Week in Cardiology

The VENTOUX study of endurance athletes, the 10,000 step myth was not busted, rate vs rhythm control for AF, and GLP1 drugs and observational studies are the topics John Mandrola, MD, discusses in this week’s podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Endurance Athletes and Arrhythmia (again)
 
 VENTOUX trial 
 https://www.ahajournals.org/doi/10.1161/CIRCIMAGING.125.018470
 
II Daily Step Count and Health — no myths were busted.
 
 Lancet Public Health: https://doi.org/10.1016/S2468-2667(25)00164-1 
III Rate vs Rhythm Control of AF
 
Medscape: Everyone Deserves a Shot at the American Dream: Sinus Rhythm
 
 https://www.medscape.com/viewarticle/everyone-deserves-shot-american-dream-sinus-rhythm-2025a1000jle
 
 This Week in Cardiology, July 11, 2025 https://www.medscape.com/viewarticle/1002704 AFFIRM trial https://www.nejm.org/doi/full/10.1056/NEJMoa021328 AFFIRM substudy https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/486560 
IV GLP-1 Drugs and Observational Studies
 
 Neurodegeneration and Stroke After Semaglutide and Tirzepatide 
 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2836412
 
 SUSTAIN-6 https://www.nejm.org/doi/full/10.1056/NEJMoa1607141 SELECT Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307563 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

July 25 2025 This Week in Cardiology

Finerenone, what not to consider when choosing treatment of AS, brain health after atrial fibrillation ablation, early rhythm control for AF, and Watchman reimbursement cuts are discussed by John Mandrola, MD, in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Finerenone
 FDA Widens Indication of Finerenone for Heart Failure Patients
 
 https://www.medscape.com/viewarticle/fda-widens-indication-finerenone-heart-failure-patients-2025a1000ive
 
 • FDA finerenone approval 
https://bayer2019tf.q4web.com/news/news-details/2025/U-S--FDA-Approves-KERENDIA-finerenone-to-Treat-Patients-With-Heart-Failure-With-Left-Ventricular-Ejection-Fraction-40-Following-Priority-Review/default.aspx • FINEARTS-HF trial 
https://www.nejm.org/doi/full/10.1056/NEJMoa2407107 
II Choosing TAVI or Surgical AVR
 
Carbon Emission when treating AS
 
 • EHJ study 
https://doi.org/10.1093/eurheartj/ehaf379 
III Brain Lesions and Visual Migraine After Left-Sided Ablations
 Post-Ablation Visual Auras a Sign of Transient Brain Injury?https://www.medscape.com/viewarticle/post-ablation-visual-auras-sign-transient-brain-injury-2025a1000iro
 
 • TRAVERSE Trial 
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.124.071352 • TRAVERSE Migraine Substudy 
https://doi.org/10.1016/j.hrthm.2025.06.035 
IV Early Rhythm Control for AF
 
 • EHJ Rapid Communication 
https://doi.org/10.1093/eurheartj/ehaf397 • EAST-AFNET 4 Trial 
https://www.nejm.org/doi/full/10.1056/NEJMoa2019422 
V Watchman Cuts
 
CMS Reduces LAAO Value in Proposed Fee Schedule https://www.acc.org/Latest-in-Cardiology/Articles/2025/07/15/20/08/CMS-Reduces-LAAO-Value-in-Proposed-2026
 
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Questions or feedback, please contact news@medscape.net

Jul 18 2025 This Week in Cardiology

Words that harm, statins, thyroid replacement, and the ISCHEMIA trial are the topics discussed by Dr John Mandrola in this week’s podcast.

Nov 8, 2019 This Week in Cardiology Podcast

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