This Week in Cardiology

Episodes

• Oct 09 2026 This Week in CardiologyListener feedback on POET II, sham control trials in atrial fibrillation, ICDs in HCM, and agenda laundering are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback POET II Response-Tailored or Standard-Duration ABX for Infectious Endocarditis POET I Trial https://www.nejm.org/doi/10.1056/NEJMoa1808312POET II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607887 II PVI-SHAM-AF trial Back in the News GAP-AF Trial https://www.ahajournals.org/doi/10.1161/circep.115.003337PVI-SHAM-AF Trial 10.1016/S0140-6736(26)01558-8 External LinkWhy Sham Studies Are a Sham in 2026 10.1016/j.hrthm.2026.09.056 External LinkThe Indispensable Role of Sham Controls in Evaluating Interventional Therapies 10.1016/j.hrthm.2026.10.001 External Link III ICDs in HCM I CDs for the Prevention of SCD in High-Risk Patients with HCM https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.078597ICDs in HCM: Editorial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079687 IV Agenda Laundering How Commercial “Agenda Laundering” Shapes Critical Care https://www.bmj.com/content/395/bmj-2026-100963 The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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• Feb 23, 2018 This Week in CardiologyAtrial fibrillation after cardiac surgery, radial vs ulnar cath access, aspirin for heart failure, VTE prophylaxis and low-fat vs high-carb diets are discussed in this week's podcast. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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• Oct 02 2026 This Week in CardiologyListener feedback on DANISH-CRT, the POET II trial, a mechanistic study in obesity and AF, the DANCODE trial of slowing CAC progression, and more on GLP-1 drugs are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback • DANISH-CRT Trial 10.1016/S0140-6736(26)01597-7 • Identifying LV Posterior Wall Delay in RBBB Using Lead V8 https://doi.org/10.1016/j.jacep.2026.03.009 • Using Lead V8 as a Tool to Improve Patient Selection in CRT https://doi.org/10.1093/europace/euaf194 II POET II Response-Tailored or Standard-Duration Antibiotics for Endocarditis • POET I https://www.nejm.org/doi/10.1056/NEJMoa1808312 • POET II https://www.nejm.org/doi/full/10.1056/NEJMoa2607887 III Obesity and AF – A Neat Study from the Team in Prague • LA Remodeling and Functional Maladaptations in Obesity https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.126.014509 IV Reducing CAC: The DANCODE Trial • DANCODE Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.082363 V Two Big RCTs of New GLP-1 Drugs • TRIUMPH-1 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2604169 • SYNCHRONIZE-2 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607219 The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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• Sep 25 2026 This Week in CardiologyListener feedback, pulmonary embolism intervention, simple vs complex in BiV pacing, exercise in AF, and TAVR for paradoxical low-flow, low-gradient aortic stenosis are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback LBBP ICD Lead • LEADR LBBAP Trial https://pubmed.ncbi.nlm.nih.gov/41110529/ TRIC-I-HF trial • TRIC-I-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2606934 • Growth of Tricuspid Interventions in Germany https://www.jacc.org/doi/10.1016/j.jcin.2025.05.030 II Treatment of Acute Intermediate-High Risk PE – the PRAGUE-26 Trial • PRAGUE-26 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2608012 III Targeting CS leads in CRT devices – DANISH-CRT Trial • DANISH-CRT Trial 10.1016/S0140-6736(26)01597-7 IV Exercise for AF, Especially When There Is LA Disease • Physical Activity and Risk of Incident AF in Atrial Cardiomyopathy https://www.jacc.org/doi/10.1016/j.jacadv.2026.102999 V Paradoxical Low-Flow, Low-Gradient AS – REBOOT-PARADOX • REBOOT-PARADOX trial 10.1016/j.jacc.2026.08.017 • ROTAS Trial https://heart.bmj.com/content/110/20/1223 The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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• Sep 18 2026 This Week in CardiologyAnother ESC recap, listener feedback on two trials, and a paper on GLP-1 effects on inflammation from the SELECT trial are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Correction on PROFID Trial II Listener Feedback III Fifth Universal Definition of MI • Fifth Universal Definition of MI https://doi.org/10.1093/eurheartj/ehag101 • Foy/Mandrola Editorial on Troponin Use and Interpretation https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2777967 IV New ESC HF Guidelines • ESC Guidelines for Management of HF https://doi.org/10.1093/eurheartj/ehag100 • Sanjay Kaul on X https://x.com/kaulcsmc/status/2094959683215958158?s=20 • Geographic Disparities in TOPCAT https://pmc.ncbi.nlm.nih.gov/articles/PMC5065247/ V AIR STEMI Trial • AIR-STEMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2605373 • CR Strategies After MI https://www.jacc.org/doi/10.1016/j.jacc.2024.04.051 • PRAMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1305520 • COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775 • FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149 VI GLP-1 News – A SELECT Trial Secondary Analysis • Semaglutide and hsCRP in Patients with CVD and Obesity https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.074482 The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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• Sep 11 2026 This Week in CardiologyA second ESC recap plus two breaking stories on the failure of an investigational Lp(a) reducing drug and a new FDA approval of an AI-ECG app are covered by John Mandrola, MD This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Lp(a) Disappointment • HORIZON https://clinicaltrials.gov/study/NCT04023552 • Press Release https://www.novartis.com/news/media-releases/novartis-announces-lpahorizon-phase-iii-topline-results-pelacarsen-patients-elevated-lpa-and-established-cardiovascular-disease-cvd • Rationale paper https://doi.org/10.1016/j.ahj.2025.03.019 II FDA Clears AI-ECG for Acute MI Detection • Accuracy of cath lab activation decisions for STEMI-equivalent and mimic ECGs: Physicians vs. AI (Queen of Hearts by PMcardio) 10.1016/j.ajem.2025.07.061 • AI-Enabled ECG Analysis Improves Diagnostic Accuracy and Reduces False STEMI Activations: A Multicenter U.S. Registry https://www.jacc.org/doi/10.1016/j.jcin.2025.10.018 • Queen of Hearts™ AI ECG App https://www.powerfulmedical.com/pmcardio-stemi/ III TARGET CTCA Trial • Targeted Use of Computed Tomographic Coronary Angiography in Acute Chest Pain https://www.nejm.org/doi/10.1056/NEJMoa2608903 IV CorCal trial • Press release https://www.escardio.org/news/press/press-releases/new-data-presented-on-the-use-of-coronary-artery-calcium-for-cardiovascular-risk-assessment/ • CorCal Outcomes: A randomized trial using the pooled cohort equation or coronary artery calcium to select statin therapy in primary prevention patients. Study design and baseline characteristics https://doi.org/10.1016/j.ahj.2026.107473 V AMUNDSEN Trial • LDL Cholesterol Lowering With Evolocumab Before Percutaneous Coronary Intervention for Acute Myocardial InfarctionThe AMUNDSEN Randomized Clinical Trial https://jamanetwork.com/journals/jama/fullarticle/2853274 VI TRIC-I-HF trial • Tricuspid Repair Cuts Death, HF Hospitalization in Severe TR https://www.medscape.com/viewarticle/tricuspid-repair-cuts-death-hf-hospitalization-severe-tr-2026a1000wvk • Tricuspid-Valve Intervention in Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa2606934 You May Also Like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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• Sep 04 2026 This Week in CardiologyESC recaps on the SINGLE-AF trial, CMR Guide trial, two ATTR studies, PVI-SHAM-AF, STAREE, and an observational study of ICD benefit over the past decades are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I SINGLE-AF Trial To Anticoagulate or Not in Intermediate-Risk AF: The SINGLE-AF Trial https://www.medscape.com/viewarticle/anticoagulate-or-not-intermediate-risk-af-single-af-trial-2026a1000uko • SINGLE-AF https://www.nejm.org/doi/10.1056/NEJMoa2607978 II Scar as an ICD risk stratifier Is Scar on CMR an Indication for ICD? CMR Guide Leaves Doubts https://www.medscape.com/viewarticle/scar-cmr-indication-icd-cmr-guide-leaves-doubts-2026a1000ukq • CMTR GUIDE Trial https://jamanetwork.com/journals/jama/fullarticle/2853395 • MADIT II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa013474 III Single vs Dual Therapy in ATTR-CM • HELIOS-B Trial Sub-analysis https://www.sciencedirect.com/science/article/pii/S0735109726072086 • HELIOS-B Sub-analysis Editorial https://www.sciencedirect.com/science/article/pii/S0735109726073766#bib8 • HELIOS-B main trial https://www.nejm.org/doi/10.1056/NEJMoa2409134 • CARDIO-TTRansform Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2608510 IV A Stunning Result of another Sham-controlled AF ablation trial Does AF Ablation Work? That's in Question After PVI-SHAM-AF https://www.medscape.com/viewarticle/does-af-ablation-work-s-question-after-sham-pvi-af-2026a1000uli • PVI-SHAM-AF Trial 10.1016/S0140-6736(26)01558-8 External Link • SHAM-PVI Trial https://jamanetwork.com/journals/jama/fullarticle/2823283 • PFA-Sham Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079484 V Should Older Adults Take Statins: The STAREE trial. STAREE Strengthens Case for Over-the-Counter Statins https://www.medscape.com/viewarticle/staree-strengthens-case-over-counter-statins-2026a1000vrw • STAREE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607314 VII Declining ICD Benefit After MI • Mortality Reduction with ICD for Prevention of SCD Post-MI https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag706/8768943 • CONTEMP-ICD Trial https://clinicaltrials.gov/study/NCT06543446 • PROFID-EHRA Trial https://profid-project.eu/profid-ehra-trial/ The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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• Aug 28 2026 This Week in CardiologyListener feedback on mechanical CPR devices, PFA and stroke, the Lindy effect in adopting new technology, and an ESC preview are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback on Mechanical Compression Devices for OHCA • Mechanical CPR Device Use and Cardiac Arrest Survival https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079272 • PARAMEDIC trial https://www.thelancet.com/article/S0140-6736(14)61886-9/fulltext • CIRC trial https://www.resuscitationjournal.com/article/S0300-9572(14)00128-2/fulltext • LINC trial https://jamanetwork.com/journals/jama/fullarticle/1774037 • Cochrane Review – Mechanical vs Manual Chest Compressions for Cardiac Arrest https://pmc.ncbi.nlm.nih.gov/articles/PMC6953326/ II PFA and Stroke • Risk of Stroke and TIA With PFA vs RF Ablation https://www.ahajournals.org/doi/epub/10.1161/CIRCULATIONAHA.126.081092 • AVANT GUARD Trial https://www.nejm.org/do/10.1056/NEJMdo008538/full/ • EMBOL-AF Registry https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag217/8566008 III A New ICD Lead • LEADR LBBAP Trial https://doi.org/10.1016/j.hrthm.2026.08.030 IV ESC Preview • Mandrola's Preview of the European Society of Cardiology 2026 https://www.medscape.com/viewarticle/mandrolas-preview-european-society-cardiology-2026-2026a1000tfi You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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• August 21 2026 This Week in CardiologyMechanical CPR devices, the dangers of AF performance measures, two scholarly articles on CLOSURE and CHAMPION, and a little ESC preview are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Mechanical Compression Devices for OHCA · Mechanical CPR Device Use Cardiac Arrest Survival https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079272 · PARAMEDIC Trial https://www.thelancet.com/article/S0140-6736(14)61886-9/fulltext · CIRC Trial https://www.resuscitationjournal.com/article/S0300-9572(14)00128-2/fulltext · LINC trial https://jamanetwork.com/journals/jama/fullarticle/1774037 · Cochrane Review of Mechanical vs Manual Chest Compressions for Cardiac Arrest https://pmc.ncbi.nlm.nih.gov/articles/PMC6953326/ II ACC AF Performance Measures · 2026 AHA/ACC Clinical Performance for Patients With AF https://www.jacc.org/doi/10.1016/j.jacc.2026.05.032#sec-3 III Two Critical Appraisals of the recent LAAC trials · Reappraising CHAMPION-AF 10.1016/j.hrthm.2026.07.048 External Link · CHAMPION and CLOSURE: Reconciling Contrast Results https://doi.org/10.1093/eurheartj/ehag608 ESC Early Preview · CMR Guide trial https://pmc.ncbi.nlm.nih.gov/articles/PMC6931571/ · SINGLE AF Trial 10.1016/j.hroo.2025.12.008 External Link You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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• Aug 14 2026 This Week in CardiologyListener feedback, the ZEUS trial fails, a fascinating statin trial, more on GLP-1 drugs, and radiation safety in the EP lab are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I ZEUS Fails Rethinking Inflammation and ASCVD: Four Lessons From the ZEUS Trial https://www.medscape.com/viewarticle/rethinking-inflammation-and-ascvd-four-lessons-zeus-trial-2026a1000rlm • ZEUS Trial https://doi.org/10.1001/jamacardio.2025.4491 II Statins and the Elderly • SAGA/SITE trial 10.1016/j.lanhl.2026.100884 External Link III GLP-1 and CV Risk • SURMOUNT-1 Trial https://www.nejm.org/doi/10.1056/NEJMoa2206038 • SURMOUNT-1 Post Hoc Analysis https://www.jacc.org/doi/10.1016/j.jacc.2026.04.044 • Reframing GLP-1s as Cardiometabolic Health Drugs: Editorial https://www.jacc.org/doi/10.1016/j.jacc.2026.06.039 IV Radiation Exposure to the Uterus in the EP Lab • Occupational Radiation Safety in EP During Pregnancy https://www.ahajournals.org/doi/epub/10.1161/CIRCULATIONAHA.126.080556 • Survey: Working in Cath Lab During Pregnancy https://www.surveymonkey.com/share/d5c1edf7-6d99-49d4-a9fa-e9168f63ab55 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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