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Medscape

This podcast delivers Dr. John Mandrola's summary and perspective on top news of the week that cardiologists can't miss. This podcast is intended for US health professionals only.

This Week in Cardiology

John Mandrola offers an ACC recap of 5 big trials—Hi-PEITHO, PROTAVI, ORBITA-CTO, CHIPS-BCIS3 and CHAMPION AF
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Catheter Based Fibrinolysis of Pulmonary Embolism –Hi PEITHO
 
 Fibrinolysis Treatment Validated in Large Trial for Acute Intermediate-Risk PE https://www.medscape.com/viewarticle/fibrinolysis-treatment-validated-large-trial-acute-2026a10009im Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism (HI PEITHO) https://www.nejm.org/doi/full/10.1056/NEJMoa2516567 National Early Warning Score (NEWS) https://www.england.nhs.uk/ourwork/clinical-policy/sepsis/nationalearlywarningscore/ 
II PRO-TAVI trial
 
 Deferral of percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation (PRO-TAVI) 10.1016/S0140-6736(26)00308-9 External Link PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation (Notion 3) https://www.nejm.org/doi/full/10.1056/NEJMoa2401513 
III ORBITA CTO Sham vs PCI for Angina Relief
 
 Tightly Blinded Trial Confirms PCI Reduces Angina in Obstructive Occlusion https://www.medscape.com/viewarticle/tightly-blinded-trial-confirms-pci-reduces-angina-2026a10009ob A Randomized, Placebo-Controlled Trial of Chronic Total Occlusion Percutaneous Coronary Intervention in Stable Angina - ORBITA-CTO https://www.jacc.org/doi/10.1016/j.jacc.2026.03.027 ORBITA 1 10.1016/S0140-6736(17)32714-9 External Link ORBITA 2 https://www.nejm.org/doi/full/10.1056/NEJMoa2310610 DECISION CTO https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.031313 EuroCTO https://doi.org/10.1093/eurheartj/ehy220 • 
 
IV CHIPS BCIS3 Impella Supported High-Risk PCI
 
 Adoption Before Evidence: CHIP-BCIS3 Humbles Impella https://www.medscape.com/viewarticle/adoption-before-evidence-chip-bcis3-humbles-impella-2026a10009jh Left Ventricular Unloading in High-Risk PCI (CHIP BCIS3) https://www.nejm.org/doi/full/10.1056/NEJMoa2515704 Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock (DanGer Shock) https://www.nejm.org/doi/full/10.1056/NEJMoa2312572 
V CHAMPION AF – Watchman vs DOAC in Patients With AF
 
 CHAMPION-AF Trial Finds LAAC an Alternative for NOAC in Lower-Risk Patients https://www.medscape.com/viewarticle/champion-af-trial-finds-laac-alternative-noac-lower-risk-2026a10009ij Six Reasons Why CHAMPION-AF Should Not Change Practice https://www.medscape.com/viewarticle/six-reasons-why-champion-af-should-not-change-practice-2026a10009i7 Left Atrial Appendage Closure or Anticoagulation for Atrial Fibrillation (CHAMPION AF) https://www.nejm.org/doi/full/10.1056/NEJMoa2517213 Left Atrial Appendage Closure or Medical Therapy in Atrial Fibrillation (CLOSURE AF) https://www.nejm.org/doi/full/10.1056/NEJMoa2513310 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Apr 03 2026 This Week in Cardiology

Early aortic valve replacement in aortic stenosis, left atrial appendage occlusion in JAMA Cardiology, and a big preview of the upcoming American College of Cardiology meeting are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Early AVR
 
 RECOVERY Trial at 10 Years https://www.nejm.org/doi/full/10.1056/NEJMoa2511920 
II Major Bleeding with Amulet and Watchman in JAMA Cardiology
 
 Amulet IDE Trial • 
https://jamanetwork.com/journals/jamacardiology/fullarticle/2847047 5-year Results From Amulet IDE • 
https://www.jacc.org/doi/10.1016/j.jacc.2024.10.101 
III ACC Preview
 
Mandrola's Top 4 Trials from ACC 2026: Details Matter
 
 https://www.medscape.com/viewarticle/mandrolas-top-4-trials-acc-2026-details-matter-2026a10008ti
 
 CHIB-BCIS3 Trial • 
https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.123.013367 Champion-AF Protocol • https://doi.org/10.1016/j.ahj.2023.05.022
 ORBITA-CTO Protocol Paper • https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1172763/full
 SPIRIT-HF Clinical Trials.gov • https://clinicaltrials.gov/study/NCT04727073
 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Mar 27 2026 This Week in Cardiology

Listener feedback, the huge CLOSURE-AF trial of LAAC vs best medical therapy, previews of CHAMPION AF, and the controversial ACC/AHA lipid treatment guidelines are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Listener Feedback
 
 COBRRA Trial • https://www.nejm.org/doi/full/10.1056/NEJMoa2510703
 
Closure AF published in NEJM
 
 CLOSURE-AF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2513310 CHAMPION AF Rationale - Watchman FLX vs DOACs in Patients With AF https://pubmed.ncbi.nlm.nih.gov/37279840/ 
LIPID Guidelines
 
 ACC/AHA Joint Committee Guideline on Management of Dyslipidemia https://www.jacc.org/doi/10.1016/j.jacc.2025.11.016 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Mar 20 2026 This Week in Cardiology

Beta-blocker in non-obstructive hypertrophic cardiomyopathy, a head-to-head apixaban vs rivaroxaban RCT, diltiazem vs metoprolol combined with DOAC, and the accuracy of smart watches for AF are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Listener Feedback
 
 EMPATICC trial https://academic.oup.com/eurheartj/article/47/9/1034/8242490 
II Beta-blocker in Non-obstructive HCM
 
 BB vs Calcium Channel Blocker in Non-obstructive HCM https://doi.org/10.1016/j.jacc.2025.11.028 RCT of Metoprolol in Patients With Obstructive HCM https://doi.org/10.1016/j.jacc.2021.07.065 
III Apixaban vs Rivaroxaban for Bleeding Risk
 
 COBRRA Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2510703 AMPLIFY Trial (Apixaban) https://www.nejm.org/doi/10.1056/NEJMoa1302507 EINSTEIN Trial (Rivaroxaban) https://www.nejm.org/doi/full/10.1056/NEJMoa1007903 
IV Diltiazem vs Metoprolol When Combined with DOAC
 
 Risk for Bleeding in AF Patients Using Apixaban or Rivaroxaban With Diltiazem https://www.acpjournals.org/doi/10.7326/ANNALS-25-01408 
V Actual Clinical Use of Smart Watches
 
 CIRCA-DOSE Original Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.042622 Wearable Smartwatches for AF Detection After Ablation https://doi.org/10.1093/europace/euaf280 
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Mar 13 2026 This Week in Cardiology

Listener feedback, urgent AF ablation, AF ablation as a stroke-reducing therapy, implantable loop recorder accuracy, and HF management in the setting of serious disease are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Urgent AF ablations
 
 Urgent vs Elective AF Ablation in the US https://www.jacc.org/doi/10.1016/j.jacep.2025.12.030 
II AF Ablation Is Not Likely a Good Therapy for Stroke Reduction
 
 STABLED Trial • 
https://jamanetwork.com/journals/jamaneurology/fullarticle/2845745 Catheter Ablation for AF Associated With Lower Incidence of Stroke • 
https://doi.org/10.1093/eurheartj/ehw087 
III Loop Recorders
 
 ILR Accuracy - Multicenter, Multidevice Comparison • 
https://doi.org/10.1016/j.jacep.2025.12.039 
IV Heart Failure Therapy when there is Cancer
 
 EMPATICC Trial • 
https://doi.org/10.1093/eurheartj/ehaf705 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Mar 06 2026 This Week in Cardiology

A superb note on CPR and DNR orders, patients' vs doctors' preferences for statins, more on GLP-1s, another LAAC story, and some closing cautionary notes on PFA are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Listener Feedback
 
 Addressing Inadequate Documentation of Unilateral DNR https://jamanetwork.com/journals/jama/fullarticle/2829203 Video: Can We Talk About CPR? https://www.youtube.com/watch?v=yTCRfY3ETvI Personal Reminiscences of CPR's Origin https://www.ajconline.org/article/S0002-9149(03)00977-9/pdf 
II Public Preferences for Statin Therapy
 
 Measuring Public Preferences for Statin Therapy • 
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2844660 
III GLP-1 RA News
 
 ACHIEVE Trial • 
https://doi.org/10.1016/S0140-6736(26)00202-3 
IV New Trial in GLP-1 for Patients with AF
 
 Seminal-AF Trial • 
https://clinicaltrials.gov/study/NCT06499857 
V Relationship between Spontaneous Echo Contrast and LAAC Outcomes
 
 OCEAN-LAAC Trial • 
https://doi.org/10.1016/j.jacep.2025.09.028 News Release on Upcoming LAAOS-4 trial • 
https://www.phri.ca/watchman/ Reading the "Smoke" -- Editorial on OCEAN-LAAC • 
https://www.jacc.org/doi/10.1016/j.jacep.2025.10.029 
VI Concluding Remarks on My Talk at Western AF
 
 Delayed Myocardial Ischemia and Malignant Arrhythmias After PFA • 
https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.125.077983 
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

Feb 27 2026 This Week in Cardiology

EVOLUT Low Risk data, a provocative meta-analysis, DNR orders, targeted hypothermia, good news in HFpEF evidence, and GLP-1s as AF drugs are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I EVOLUT Low Risk 6-year Results and a 5-year Meta-Analysis of TAVR vs SAVR
 
 6-Year Outcomes of TAVR vs SAVR https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5063 EVOLUT Low Risk Trial at 2 years https://www.nejm.org/doi/full/10.1056/NEJMoa1816885 EVOLUT Low Risk Trial at 3 years https://www.jacc.org/doi/10.1016/j.jacc.2023.02.017 EVOLUT Low Risk Trial at 4 years https://www.jacc.org/doi/10.1016/j.jacc.2023.09.813 Nonproportional Hazards for Time-to-Event Outcomes in Clinical Trials https://www.jacc.org/doi/10.1016/j.jacc.2019.08.1034 TAVR vs SAVR 5-Year Outcomes - Systematic Review https://heart.bmj.com/content/early/2026/02/11/heartjnl-2025-327092 TAVR vs SAVR Updated Meta-Analysis of RCTs https://www.jacc.org/doi/10.1016/j.jacc.2024.12.031 UK TAVI Trial https://jamanetwork.com/journals/jama/fullarticle/2792251 Dr David Cohen on X https://x.com/djc795/status/2023556582030852172?s=46&t=zXMCUoVjSsdyemzWlzeBjA 
II DNR in the Hospital
 
 Inadequate Documentation of Unilateral DNR Orders • 
https://jamanetwork.com/journals/jama/fullarticle/2829203 GeriPal Blog Unilateral DNR Orders • 
https://geripal.org/unilateral-dnr-gina-piscitello-erin-demartino-will-parker/ 
III Yet another failure of Targeted Hypothermia
 
 2-Year Follow-Up of TTM2 Trial • 
https://jamanetwork.com/journals/jamaneurology/fullarticle/2845193 TTM2 Trial • 
https://www.nejm.org/doi/full/10.1056/NEJMoa2100591 
IV Good news in HFpEF Evidence
 
 ALT-FLOW II Trial • 
https://doi.org/10.1093/ejhf/xuaf016 
V GLP-1 as AF drugs
 
 Semaglutide as Adjunctive Therapy in Obesity-Related PAF • 
https://doi.org/10.1093/europace/euag018 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Feb 20 2026 This Week in Cardiology

Ticagrelor vs prasugrel, a new LAAC device, pulsed field ablation AF results, lifestyle intervention in AF, the term "provider" vs "doctor," and coffee are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I TUXEDO-2 Trial
 
 TUXEDO-2 Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2844869 ISAR-REACT 5 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1908973 
II VERITAS Study of Dual-Seal LAAO
 
 VERITAS Study • 
https://doi.org/10.1016/j.jacep.2026.01.021 
III PFA vs RF over 4 years
 
 Advent-LTO study • 
https://www.nature.com/articles/s41591-026-04246-4 ADVENT Study • 
https://www.nejm.org/doi/full/10.1056/NEJMoa2307291 SPHERE PER-AF Study • 
https://www.nature.com/articles/s41591-024-03022-6
 • 
SINGLE SHOT CHAMPION Study • 
https://www.nejm.org/doi/full/10.1056/NEJMoa2502280 BEAT PAROX-AF Trial • 
https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaf1115/8436829 
IV What's in a Name — Use of the Term "Provider"
 
 Physicians Are Not Providers: The Ethical Significance of Names • 
https://www.acpjournals.org/doi/10.7326/ANNALS-25-03852 
V Coffee and Dementia Risk
 
 Coffee/Tea Intake and Dementia Risk • 
https://jamanetwork.com/journals/jama/fullarticle/2844764 Mandrola Commentary: Enough With the Coffee Research and Other Distractions • 
https://www.medscape.com/viewarticle/883709 
VI Lifestyle interventions Post AF ablation
 
 Improving Outcomes of AF by Lifestyle Interventions • 
https://academic.oup.com/eurheartj/article/47/6/669/8243674 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Feb 13 2026 This Week in Cardiology

Problems with the PREVENT score, a breakthrough in lipid-lowering therapy, a surprising benefit in stroke care, and more thoughts on statins and preventive care of heart disease are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I PREVENT Score
 
 PREVENT Equations in Young Adults • 
https://doi.org/10.1016/j.jacc.2025.12.019 Hospital Readmission Reduction Program for HF 
 https://pmc.ncbi.nlm.nih.gov/articles/PMC7664458/
 
II A New Breakthrough in LDL-C Management With an Oral PCSK9 Inhibitor
 
 https://www.medscape.com/viewarticle/time-overcome-pcsk9i-inertia-new-data-future-options-2025a1000wf8
 
 CORALreef Trial • 
https://www.nejm.org/doi/full/10.1056/NEJMoa2511002 CORALreef Outcomes Trial • 
https://clinicaltrials.gov/study/NCT06008756 
III A Win for the Factor XI Inhibitor Asundexian – OCEANIC Stroke Trial
 
 https://www.medscape.com/viewarticle/first-clear-win-factor-xia-inhibitors-stroke-reduced-2026a10003t0
 
 OCEANIC-STROKE Slide deck • 
https://clinicaltrialresults.org/wp-content/uploads/2026/02/26-02-02_ISC_OCEANIC-STROKE-primary.pdf OCEANIC-AF Study Stopped Early • 
https://www.bayer.com/media/en-us/oceanic-af-study-stopped-early-due-to-lack-of-efficacy/ 
IV Statin Side Effects
 
 Assessment of AEs Attributed to Statins -- Meta-analysis • 
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01578-8/fulltext N-of-1 Trial to Assess AEs of Statins • 
https://www.nejm.org/doi/full/10.1056/NEJMc2031173 When to Start a Statin Is a Decision About Preference -- Editorial • 
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.029808 
V Heart Disease Statistics
 
 CV Statistics in the US, 2026 • 
https://www.jacc.org/doi/10.1016/j.jacc.2025.12.027 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Feb 06 2026 This Week in Cardiology

Listener feedback, huge news in the rapidly expanding world of PFA AF Ablation, obesity, and a beautiful trial studying an AI-enhanced diagnostic tool in the office are the topics discussed by John Mandrola, MD, in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Listener Feedback
 
 Risk-Based TEE Omission in PVI • 
10.1016/j.hrthm.2025.04.056 External Link 
II PFA News
 
 BEAT PAROX-AF trial • 
https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaf1115/8436829 Life-Threatening Delayed Myocardial Ischemia and Malignant Arrhythmias Occurring After PFA • 
https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.125.077983 Heart Rhythm TV: Life-Threatening Delayed Myocardial Ischemia and Malignant Arrhythmias https://www.youtube.com/watch?v=M-npoLKmRa4 MAUDE Adverse Event report • 
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfmaude/detail.cfm?mdrfoi__id=23733351&pc=QZI 
III Obesity trends
 
 US State-Level Obesity Trends 1990-2022 and Forecasted to 2035 • 
https://jamanetwork.com/journals/jama/fullarticle/2844495 
IV New Tools in the Office
 
 TRICORDER Trial • 
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02156-7/fulltext 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Mar 27 2026 This Week in Cardiology

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