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Blockworks

The Breakdown dives into the deepest topics in crypto, blockchain, and the macro forces shaping markets and power structures. Each episode breaks down complex ideas into clear, grounded analysis — separating signal from noise across crypto, finance, and geopolitics.

Hosted by David Canellis, The Breakdown features explainers, interviews, and conversations with the people building, regulating, and challenging the financial system.

A Blockworks podcast.

Subscribe to The Breakdown newsletter: https://the-breakdown.carrd.co/

The Breakdown

David covers three Wednesday stories: Coinbase laying off 14% of staff, a16z Crypto raising $2.2 billion, and Strategy losing $12.5 billion as CEO Phong Le floats selling bitcoin.

We also unpack the AI-first layoff narrative, the potential return of the infra supercycle ($6B+ raised across crypto VCs in 2026), and why a Cambrian explosion of DATs and ETFs might absorb whatever Saylor has to offload. Enjoy!

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TIMESTAMPS:

(00:00) Intro

(01:17) Coinbase Layoffs

(07:15) Nexo Ad

(07:50) Coinbase Layoffs (Cont.)

(10:30) a16z Crypto Fund 5

(15:17) Nexo Ad

(16:09) a16z Crypto Fund 5 (Cont.)

(22:30) Strategy Losses

FOLLOW THE SHOW

› David — https://x.com/dcanellis

› The Breakdown — https://x.com/TheBreakdownBW

SPONSORS

› NEXO

Nexo is the premier digital wealth platform. Receive interest on your crypto, borrow against it without selling, and trade a range of assets. Now available in the U.S with 30 days of exclusive privileges. Get started at http://nexo.com/breakdown

Get top market insights and the latest in crypto news. Subscribe to the Blockworks Daily Newsletter: https://blockworks.co/newsletter/

DISCLAIMER

As always, remember this podcast is for informational purposes only, and any views expressed by anyone on the show are solely their opinions, not financial advice.

Coinbase's AI Layoffs, a16z's $2.2B Fund, and Strategy's $12.5B Loss | The Breakdown

David runs through three Monday morning stories: the viral Clavicular clip with Polymarket’s CMO, the CLARITY Act’s compromise on stablecoin yield, and MegaETH’s adoption numbers a week into its points campaign.

TIMESTAMPS:

(00:00) Intro

(01:06) Clavicular and Polymarket CMO

(09:20) Nexo Ad

(09:57) CLARITY Act Update

(15:03) Nexo Ad

(15:54) MegaETH Performance

FOLLOW THE SHOW

› David — https://x.com/dcanellis

› The Breakdown — https://x.com/TheBreakdownBW

SPONSORS

› NEXO

Nexo is the premier digital wealth platform. Receive interest on your crypto, borrow against it without selling, and trade a range of assets. Now available in the U.S with 30 days of exclusive privileges. Get started at http://nexo.com/breakdown

Get top market insights and the latest in crypto news. Subscribe to the Blockworks Daily Newsletter: https://blockworks.co/newsletter/

DISCLAIMER

As always, remember this podcast is for informational purposes only, and any views expressed by anyone on the show are solely their opinions, not financial advice.

Clavicular x Polymarket, the CLARITY Act, and What MegaETH Tells Us About Retail | The Breakdown

DeFi just raised $302 million to cover losses from the Kelp DAO hack. David calls it what it is: a bailout.

David runs through four stories from the week — MegaETH, DeFi United, Meta’s stablecoin payouts, and the Blockworks rebrand.

We unpack why MegaETH’s points campaign is the 2021 playbook in 2026, why stablecoin income doesn’t equal crypto adoption, and what happens when the house money runs out. Enjoy!

TIMESTAMPS:

(00:00) Introduction

(01:14 MegaETH)

(13:34 Nexo Ad)

(14:11 DeFi United)

(21:20 Nexo Ad)

(22:12 Meta Stablecoins)

(30:14 Blockworks Valuation)

FOLLOW THE SHOW

› David — https://x.com/dcanellis

› The Breakdown — https://x.com/TheBreakdownBW

SPONSORS

› NEXO

Nexo is the premier digital wealth platform. Receive interest on your crypto, borrow against it without selling, and trade a range of assets. Now available in the U.S with 30 days of exclusive privileges. Get started at http://nexo.com/breakdown

Get top market insights and the latest in crypto news. Subscribe to the Blockworks Daily Newsletter: https://blockworks.co/newsletter/

DISCLAIMER

As always, remember this podcast is for informational purposes only, and any views expressed by anyone on the show are solely their opinions, not financial advice.

MegaETH, the DeFi United Bailout, Meta’s USDC Push, and Blockworks Reaches $192M Valuation | The Breakdown

North Korea has had IT workers embedded in DeFi protocols since DeFi Summer — and they’re pretty good devs.

Nick Bax, blockchain investigator and SEAL 911 incident responder, joins us to break down how crypto crime has evolved from SIM swaps to nation-state social engineering.

We unpack the Monero inflation bug, Arbitrum’s 9/12 multisig gold standard, how DPRK workers now use facilitators to rent real identities, and what it actually takes to break into onchain investigation. Enjoy!

TIMESTAMPS:

(00:00) Introduction

(02:01) DeFi is Under Attack

(03:11) Contagion Onchain

(04:40) Nexo Ad

(05:16) Nick Bax Interview

(06:40) Incident Response Triage

(08:43) Preemptive Due Diligence

(10:20) From SIM Swaps To Remote Access

(13:45) Multisig Best Practices

(14:37) AI Speeds Up Attacks

(15:36) Nexo Ad

(17:14) Decentralization Tradeoffs

(19:17) Monero Bug Hard Fork

(20:05) Trusting Multisig Guardians

(21:05) Two Of Five Risks

(22:00) DeFi Decentralization Debate

(23:41) Proactive Threat Hunting

(25:25) DPRK Worker Red Flags

(27:32) Security Teams And Intel

(30:21) Thorchain And Laundering

(33:26) Whack A Mole Reality

(35:31) Becoming Onchain Investigator

(37:06) Closing Thoughts

FOLLOW GUEST

› Nick Bax — https://x.com/bax1337

FOLLOW THE SHOW

› David — https://x.com/dcanellis

› The Breakdown — https://x.com/TheBreakdownBW

SPONSORS

› NEXO

Nexo is the premier digital wealth platform. Receive interest on your crypto, borrow against it without selling, and trade a range of assets. Now available in the U.S with 30 days of exclusive privileges. Get started at http://nexo.com/breakdown

Get top market insights and the latest in crypto news. Subscribe to the Blockworks Daily Newsletter: https://blockworks.co/newsletter/

DISCLAIMER

As always, remember this podcast is for informational purposes only, and any views expressed by anyone on the show are solely their opinions, not financial advice.

How Crypto Is Fighting Back Against North Korea | The Breakdown

Someone guessed Anthropic’s Mythos URL, gained unauthorized access to the most hyped AI model in history, and used it to build websites.

David covers three stories from the week: the Mythos breach, a Tether scam in the Strait of Hormuz, and DoorDash’s stablecoin announcement.

We unpack why Project Glasswing looks like marketing by association, how scammers are demanding Bitcoin and Tether for Hormuz transit, and whether DoorDash + Tempo passes David’s three-prong crypto test. Enjoy!

__

TIMESTAMPS:

(00:00) Introduction

(01:08) Unauthorized Mythos Access

(08:16) Nexo Ad

(08:51) Hormuz Scam Messages

(13:12) Nexo Ad

(14:04) DoorDash Stablecoin Payments

(22:48) Korean Wolf Memecoin

FOLLOW THE SHOW

› David — https://x.com/dcanellis

› The Breakdown — https://x.com/TheBreakdownBW

SPONSORS

› NEXO

Nexo is the premier digital wealth platform. Receive interest on your crypto, borrow against it without selling, and trade a range of assets. Now available in the U.S with 30 days of exclusive privileges. Get started at http://nexo.com/breakdown

Get top market insights and the latest in crypto news. Subscribe to the Blockworks Daily Newsletter: https://blockworks.co/newsletter/

DISCLAIMER

As always, remember this podcast is for informational purposes only, and any views expressed by anyone on the show are solely their opinions, not financial advice.

Mythos Leaks, Crypto in the Strait of Hormuz, and DoorDash Stablecoins | The Breakdown

Crypto might be the world’s best test bed for AI trading — and Virtuals Protocol is running the experiment live.

Weekee Tiew, co-founder of Virtuals Protocol, joins us to explain Degen Claw, their AI Council judging system, and why agents will soon replace wallets.

We unpack why pure P&L is the wrong benchmark, how the trench agent concept could reshape portfolio management, and what crypto’s role is in the future of finance. Enjoy!

TIMESTAMPS:

(00:00) Introduction

(05:29) Nexo Ad

(06:03) Interview with WeeKee

(09:28) Bot Strategies and Purpose of Agentic Trading

(12:16) How the “AI Council” Works

(14:39) Nexo Ad

(15:33) How Automation Fits into Benchmarks

(19:37) Incentives

(24:07) What Makes You Bullish on AI Agents and Crypto in Trading?

(26:35) LLMs vs Quants

(28:53) The Ultimate Bull Case

FOLLOW GUEST

› Weekee Tiew (Virtuals Protocol) — https://x.com/everythingempty

FOLLOW THE SHOW

› David — https://x.com/dcanellis

› The Breakdown — https://x.com/TheBreakdownBW

SPONSORS

› NEXO

Nexo is the premier digital wealth platform. Receive interest on your crypto, borrow against it without selling, and trade a range of assets. Now available in the U.S with 30 days of exclusive privileges. Get started at http://nexo.com/breakdown

Get top market insights and the latest in crypto news. Subscribe to the Blockworks Daily Newsletter: https://blockworks.co/newsletter/

DISCLAIMER

As always, remember this podcast is for informational purposes only, and any views expressed by anyone on the show are solely their opinions, not financial advice.

Can AI Actually Trade Crypto? | The Breakdown

Trump's Fed pick has 30-plus crypto investments — and that's just what he could disclose. David walks through Warsh's filing, a Polymarket bot built on the theory that nothing ever happens, and Hollywood's Craig Wright blockbuster.

TIMESTAMPS:

(00:00) Introduction

(00:21) Trying Something New

(02:47) Kevin Warsh

(08:58) Nexo Ad

(09:34) Nothing Ever Happens Polymarket Bot

(18:47) Nexo Ad

(19:38) Thoughts on Upcoming Craig Wright Bitcoin Thriller

FOLLOW THE SHOW

› David — https://x.com/dcanellis

› The Breakdown — https://x.com/TheBreakdownBW

SPONSORS

› NEXO

Nexo is the premier digital wealth platform. Receive interest on your crypto, borrow against it without selling, and trade a range of assets. Now available in the U.S with 30 days of exclusive privileges. Get started at http://nexo.com/breakdown

Get top market insights and the latest in crypto news. Subscribe to the Blockworks Daily Newsletter: https://blockworks.co/newsletter/

DISCLAIMER

As always, remember this podcast is for informational purposes only, and any views expressed by anyone on the show are solely their opinions, not financial advice.

Crypto Fed Chair, Polymarket Bots, and the Faketoshi Movie

AI is reprogramming the social fabric — and nobody can agree whether that’s a good thing.

Kevin O’Leary, investor and entrepreneur, joins us to share his framework for navigating the AI era across investing, data centers, and crypto.

TIMESTAMPS:

(00:00) Introduction

(01:33) One Shot, One Opportunity

(03:20) Two Wolves

(06:02) Nexo Ad

(06:36) Interview with Kevin O’Leary

(08:56) Datacenters as a Political Issue

(12:13) How Kevin Uses AI

(14:39) Nexo Ad

(15:36) What Makes an AI Company Worth Investing In?

(17:39) Thoughts on Negative Sentiment

(19:09) How Does Crypto Fit Into This?

(23:26) Marty Supreme Role

(25:27) Developing Taste

(29:45) Advice for Future Generations

FOLLOW GUEST

› Kevin O’Leary — https://x.com/kevinolearytv

FOLLOW THE SHOW

› David — https://x.com/dcanellis

› The Breakdown — https://the-breakdown.carrd.co/

SPONSORS

› NEXO

Nexo is the premier digital wealth platform. Receive interest on your crypto, borrow against it without selling, and trade a range of assets. Now available in the U.S with 30 days of exclusive privileges. Get started at http://nexo.com/breakdown

Get top market insights and the latest in crypto news. Subscribe to the Blockworks Daily Newsletter: https://blockworks.co/newsletter/

DISCLAIMER

As always, remember this podcast is for informational purposes only, and any views expressed by anyone on the show are solely their opinions, not financial advice.

Kevin O’Leary on AI, Data Centers, and Why He Sold 27 Crypto Positions | The Breakdown

x402 just got a lot bigger. The Linux Foundation is now backing it — and maybe Amazon, Google, Stripe, Mastercard, and American Express along with them.

In this episode, David sits down with Jordan Liu, co-founder of AIsa — one of earliest builders in the x402 ecosystem, with over 20 million microtransactions already processed.

TIMESTAMPS:

(00:00) Introduction

(01:42) What AISA Builds

(02:55) X40 Goes Linux

(07:30) Nexo Ad

(08:07) Adoption and Micropayments

(19:58) Nexo Ad and Blockworks IR Promo

(21:38) Adoption and Micropayments (Con’t)

(25:06) Protocols Roadblocks Future

FOLLOW GUEST

› Jordan Liu (AIsa) — https://x.com/AIsaOneHQ

FOLLOW THE SHOW

› David — https://x.com/dcanellis

› The Breakdown — https://x.com/TheBreakdownBW

SPONSORS

› NEXO

Nexo is the premier digital wealth platform. Receive interest on your crypto, borrow against it without selling, and trade a range of assets. Now available in the U.S with 30 days of exclusive privileges. Get started at http://nexo.com/breakdown

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Get top market insights and the latest in crypto news. Subscribe to the Blockworks Daily Newsletter: https://blockworks.co/newsletter/

DISCLAIMER

As always, remember this podcast is for informational purposes only, and any views expressed by anyone on the show are solely their opinions, not financial advice.

The Three Layers of AI Agent Commerce with Jordan Liu | The Breakdown

AI agents are coming online fast — and the payment rails for that world are being built right now.

David breaks down the race between Coinbase’s x402 and Stripe’s Machine Payments Protocol, the rise of agentic commerce, and why crypto may have a natural edge, before sitting down with Jordan Liu of AIsa.

__

TIMESTAMPS:

(00:00) Intro

(01:30) Tool Time

(03:45) AI-doption

(05:48) Nexo Ad

(06:30) When in Doubt, Incentivize

(07:36) Interview with Jordan Liu

(12:24) Nexo Ad and Blockworks IR Promo

(14:09) Interview with Jordan Liu (Con’t)

__

› Jordan Liu (AIsa) —https://aisa.one/

› David — https://x.com/dcanellis

SPONSORS

› NEXO

Nexo is the premier digital wealth platform. Receive interest on your crypto, borrow against it without selling, and trade a range of assets. Now available in the U.S with 30 days of exclusive privileges. Get started at http://nexo.com/breakdown

Get top market insights and the latest in crypto news. Subscribe to the Blockworks Daily Newsletter: https://blockworks.co/newsletter/

DISCLAIMER

As always, remember this podcast is for informational purposes only, and any views expressed by anyone on the show are solely their opinions, not financial advice.

Are AI Agents Actually Using Crypto? | The Breakdown

Today on the Brief:
 Everyone turns bullish as S&P 500 nears all-time highs
 Emerging market currencies are floundering 
 
Bitcoin holding sentiment highest in two years
 Our main conversation features Race Capital’s Chris McCann.
 Chris was previously the founder of Startup Digest, building it to 1 million subscriptions long before email newsletters were a thing. He spent four years building the community program at Greylock before launching his own venture firm. 
 In this conversation, Chris and NLW discuss:
 The relationship between monetary policy and startup finance
 What changes in startup financing have followed COVID-19
 What the emerging fintech stack looks like, outside of crypto
 Find our guest online:
 Website: Race Capital 
 Twitter: @mccannatron

How Excess Capital and Low Interest Rates Reshaped Silicon Valley, Feat. Chris McCann

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