109. LDL & Better Metabolic Health: The Keto Cholesterol 'Paradox' | Dave FeldmanYour waist shrinks. Your insulin falls. You feel better. But your LDL cholesterol goes up.
Dave Feldman joins me to unpack one of the most debated questions in low-carbohydrate nutrition: what does a substantial rise in LDL mean when other markers of metabolic health improve?
Dave is an engineer, citizen scientist and lipid researcher who originated the term “lean mass hyperresponder”. He explains his lipid energy model and why some people eating very low-carbohydrate diets develop high LDL alongside high HDL and low triglycerides.
We also examine his interpretation of the Keto-CTA research, the limitations of coronary plaque measurements, and the unanswered questions that require longer follow-up.
Our conversation goes beyond blood markers to explore vascular injury and repair, immune responses, sleep and circadian biology.
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TIMESTAMPS
00:00 Introduction to Dave Feldman and his work
02:11 Case study of a low-carb diet and lipid changes
03:10 Understanding the lipid profile improvements
04:18 The impact of high LDL in metabolic health
05:25 The role of lipoproteins in fat transport
09:47 HDL as a marker of lipid turnover
11:41 The lean mass hyperresponder phenotype
17:03 Critique of the traditional lipid hypothesis
23:29 High LDL and cardiovascular disease risk
34:29 The immune response and vascular repair
42:47 Endothelial damage, repair, and circadian rhythm
52:38 Study findings on plaque progression and regression
01:02:09 Summary and future directions in lipid research
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DISCLAIMER: The content in this podcast is purely for informational purposes and is not a substitute for professional medical advice, diagnosis, or treatment. Do not disregard professional medical advice or delay in seeking it because of something you have heard on this podcast or YouTube channel. Do not make medication changes without first consulting your treating clinician.
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