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Reid Hoffman

What if, in the future, everything breaks humanity's way? Possible is an award-winning, weekly podcast that sketches out the brightest version of the future—and what it will take to get there. Hosts Reid Hoffman and Aria Finger explore what’s possible with forward-thinking leaders, deep thinkers, and ambitious builders across many fields, such as technology, art, education and healthcare. These conversations center on the ways technology—and, in particular, AI—is shaping the future. In episodes, AI tools such as OpenAI’s GPT-4 and Inflection’s Pi are at work, offering informational asides, prompting guests, or demoing what they can do. Lastly, between guest episodes, Aria interviews her co-host Reid on his latest takes on what’s possible if we use technology—and our collective effort—effectively.

Possible

Before Kanjun Qiu raised $200 million from NVIDIA and others to build reliable AI agents, she was writing high-frequency trading algorithms to pay her way through MIT. Today she leads Imbue, an AI lab unusually focused on power, agency, and what it would take to make AI systems trustworthy by design. In this episode, Reid Hoffman and Aria Finger sit down with Kanjun to explore what it means to truly own your AI tools, not just use them; how to build agents that are systemically trustworthy, not just convincingly so; and why the future of AI may depend as much on moral invention as technical innovation. From meditation and the amygdala to Adam Smith and open-source software, this is a conversation about the deeper architecture of the AI future.

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/

What it takes to trust AI | Kanjun Qiu

Reid and Aria dig into where AI is creating real, durable value—and where they see it heading to next. Reid shares an inside look at his AI-driven drug discovery work at Manas AI, making the case that medicine could be one of the biggest opportunities in the entire AI landscape. They also explore why AI will likely shift toward a mix of specialized agents and “front doors” rather than a single dominant assistant, how enterprise vs. consumer AI revenue will evolve, and what companies like Anthropic signal about where the real business of AI is taking shape. They also touch on the role of governments in delivering AI-powered public goods, before closing with a candid conversation on political corruption, institutional trust, and why civic courage still matters.

AI’s hidden 20-year monopoly

We all feel the urgency: learn to use AI, or risk falling behind at work. And we all know there’s upside: AI can reduce tedious tasks, streamline operations, and boost output. But knowing is half the battle (maybe even less) and implementing AI needs to happen across an entire organization. So what does it take to start?

Well, here at WaitWhat (the company behind this podcast!) we paused all operations for three days to find out. From editorial curation to visual design to event planning, we split into teams for an “AI Sprint.” And this Pioneers of AI episode takes you to the starting blocks on the track with us, as we test new tools, discover their limitations, and find where AI can deliver on its promise.

Learn more about Pioneers of AI: http://pioneersof.ai/

Follow Pioneers of AI on all channels: https://linktr.ee/pioneersofai

At the center of AI is people, so we want to hear from you! Share your experiences with AI — or ask us a burning question — by leaving a voicemail at 601-633-2424. Your voice could be featured in a future episode!

How fast can you upskill in AI? We did a sprint to find out.

Reid and Aria explore how an AI-native world is reshaping trust, money, and work. Reid breaks down why crypto could power identity and transactions in an agent-driven internet, and what recent layoffs at Coinbase and Cloudflare signal about the shift toward AI-native organizations. They also examine Anthropic’s push into finance, and what it means for accuracy, regulation, and fraud. Plus, Reid responds to listener questions on “AI slop,” and why human taste and judgment matter more than ever.

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/

Anthropic’s push into finance

Beeple didn’t turn an 18-year daily JPEG habit into a $69 million Christie’s sale by waiting for permission. He posted, missed, learned, repeated, and inadvertently walked straight into the moment NFTs forced the art world to take digital work seriously. In this episode, Reid Hoffman talks with Mike Winkelmann (aka Beeple) about the real story behind the sale, why deadlines beat inspiration, how satire lets artists ask dangerous questions without preaching, and why AI is not a soul, a friend, or a shortcut. It is a tool that can—and should—make humans do more. From robot dogs with billionaire faces to AI-built sculptures shaped by strangers, Beeple argues the future is going to get much weirder, the bar for originality is rising fast, and artists who opt out may not like what happens next.

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/

The artist AI can’t kill

Reid and Aria unpack a pivotal turning point for AI as rapid advances in generative image tools, such as ChatGPT Images 2.0, lead to deeper questions on AI usage, culture, and habits. For example, they explore how these technologies could transform creative work and visual communication, before zooming out to a global debate where voices like Pope Leo’s weigh in on AI as a fundamentally human challenge. Reid argues that while risks like isolation and misinformation are real, the future of AI depends on how actively we steer it. The episode also examines a major economic shift: the move from selling software to delivering outcomes—and what that means for jobs, entrepreneurship, and entire industries.

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/

Divine intervention in AI

This week, Reid and Aria sit down with Netflix co-founder Reed Hastings. Reed has seen technology rewrite the rules of entertainment before, but AI takes him back to his beginnings: he studied it at Stanford in the late '80s, decades before it became the only conversation in tech. Few people have watched this moment build from as many vantage points: he's served on the boards of Microsoft, Meta, Bloomberg, and, now, Anthropic. 

In this episode, they talk about what AI changes in entertainment in the stories themselves, and who gets to tell them. We ask what AI can deliver for education, an area Reed has poured hundreds of millions to reform. We dig into whether the disruption coming for workers is a wages problem, a jobs problem, or something else entirely. And we ask what a two-superpower AI race means for everyone else.

Note: we recorded this episode with Reed Hastings before he announced that he won't stand for re-election to the Netflix board.

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/

Netflix co-founder Reed Hastings: stories, schools, superpowers

With AI moving from apps into the devices we use every day, Reid and Aria explore where the real value will be created. From Google Gemini powering hundreds of millions of devices to ChatGPT entering cars, Reid argues that distribution alone won’t decide winners but that depth of use, iteration, and personalization will. They also examine the $650B race to build AI infrastructure, the hidden bottlenecks and geopolitical risks behind it, and why U.S. capital still provides a key edge. Finally, they highlight the Trust in American Institutions Challenge and its winner as a case for how AI can help rebuild trust by making institutions more transparent and accountable.

The grid(lock) slowing AI down

Reid and Aria unpack the geopolitical battle over chips, from U.S. export controls to China’s push for self-sufficiency, and how the race for compute is reshaping global power. They then turn to how AI is rapidly expanding the attack surface, driving more frequent breaches and exposing new vulnerabilities deep in the software stack as speed and scale outpace traditional defenses. Finally, they explore why enterprise AI adoption has been slower and more uneven than expected, and how network effects, organizational inertia, and trust constraints are shaping the path forward. Together, these forces show how AI is not just advancing technologically, but quietly transforming the foundations of security, competition, and economic power.

AI’s expanding attack surface

In this episode of Possible, Reid Hoffman and Aria Finger talk with Sean Neville, co-founder of Circle and architect of USDC, about building the financial infrastructure for an AI-driven economy. Now leading Catena Labs, Neville is working on what he calls the first AI-native bank—designed for autonomous agents that can transact, comply, and interact without humans in the loop. The conversation explores what breaks when AI tries to use today’s financial rails, why stablecoins may power machine-to-machine commerce, and why new concepts like “Know Your Agent” could become the foundation of trust in an AI financial system. 

For more info on the podcast and transcripts of all the episodes, visit https://www.possible.fm/podcast/

What it takes to trust AI | Kanjun Qiu

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