Do you think one bad night of sleep can really harm your body? Would you try a routine that could help you reverse aging? Today, Jay sits down with Bryan Johnson, entrepreneur and founder of Blueprint, who is redefining human health and longevity. Dubbed "the world's most measured human," Bryan shares his extraordinary journey of reversing aging and improving biological performance through science-backed methods and a meticulously designed lifestyle. Bryan discusses how his $2 million-a-year protocol isn't just about extreme spending but about pioneering a blueprint for everyone. He explains the concept of "don't die," emphasizing the potential for humanity to extend life and improve health at unprecedented levels. From his diet of precision-crafted meals to his groundbreaking work in measuring microplastics and organ health, Bryan's insights challenge conventional norms about aging, health, and longevity. Together with Jay, Bryan dives deep into actionable takeaways, such as the five pillars of perfect sleep, the importance of building systems over relying on willpower, and how to minimize exposure to environmental toxins like microplastics. Bryan also addresses controversial topics, including the downsides of cheat days and the role of technology in managing health. In this interview, you'll learn: How to Reverse Aging Through Measured Health Metrics How to Optimize Your Diet for Longevity How to Manage Stress With Better Sleep How to Create a System for Healthy Living How to Rewire Your Taste Buds for Better Nutrition How to Lower Inflammation With Simple Daily Habits You don’t need millions of dollars or cutting-edge technology to start—just a commitment to making small, intentional changes. With Love and Gratitude, Jay Shetty Check out the On Purpose Merch! https://jayshettyshop.com. 100% of Proceeds are donated to National Alliance on Mental Illness. NAMI is the nation’s largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. What We Discuss: 00:00 Intro 02:31 How Long Can a Person Live? 04:19 The Most Measured Person 06:34 Getting Sustained Hearing Impairment 09:57 Extending Life Before Conception 11:18 How Long Do We Have to Live? 14:22 Every Body I Highly Responsive to Change 16:50 Embryo Selection Through Genetic Markers 18:12 A Generation of Microplastic 20:42 Simple Ways to Minimize the Influx of Microplastic 23:05 Don’t Drink from Water Bottles 26:01 The Significant Health Threat of Air Pollution 30:11 How Capitalism Affects Health 32:28 5 Ways to Get Better Sleep 40:12 Don’t Miss Your Deep Sleep Window 43:37 The Ill Effects of Poor Sleep 45:48 Invest in Your Health 48:12 What’s Your Protein Intake? 51:22 Bryan’s Perfect Diet 56:11 Eating 3 Meals a Day in 5 Hours 58:21 Rewire Your Taste Buds 59:19 Sensitivity to Air Quality 01:02:36 Are You Scared of Dying? 01:05:58 Prolonging Longevity 01:08:07 Ways to Manage Stress 01:11:00 You Are not Your Thoughts 01:15:37 Health Can Lead to Happiness 01:19:37 Is Reverse Aging Possible? 01:22:25 Bryan on Final Five Episode Resources: Bryan Johnson | Website Bryan Johnson | X Bryan Johnson | Instagram Bryan Johnson | Tiktok Bryan Johnson | Youtube Bryan Johnson | LinkedIn Blueprint Protocol

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