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Andreessen Horowitz

The a16z Podcast discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!

a16z Podcast

What exactly is an AI agent — and does anyone actually agree?

In this episode, taken from of AI + a16z, General Partner Guido Appenzeller and partners Matt Bornstein and Yoko Li break down one of the most hyped- and most hotly debated 0 concepts in AI right now: agents.

Are agents just clever wrappers around LLMs? Tools that can reason and act? Or simply a fresh label for familiar tech?

Whether you're building, investing, or just trying to make sense of the buzz, this episode is for you.

Resources:
Find Guido on X: https://x.com/appenz

Find Yoko on X: https://x.com/stuffyokodraws

Find Matt on X: https://x.com/BornsteinMatt

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://x.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

What Is an AI Agent?

Did you know the U.S. nurse labor market is over $600 billion annually, but the dedicated software market for nurses is almost zero?

In this episode General Partners Alex Rampell, David Haber, and Angela Strange discuss how AI is revolutionizing labor by automating tasks traditionally done by humans.

They’ll trace the evolution of cloud eras — from the original to financial services-enabled to the current AI-enabled outcomes era — showcasing how AI is creating unprecedented opportunities, allowing startups to outpace incumbents. They also explore how this shift will reshape industries, where we are in the adoption curve and what companies need to succeed, and the gaps where the a16z Enterprise team would love to see more innovation.

Resources:

 • AI Turns Capital to Labor: 
 https://a16z.com/ai-turns-capital-to-labor/ • The Messy Inbox Problem: 
https://a16z.com/the-messy-inbox-problem-ai-apps-wedge-strategies/ • Vertical SaaS: Now with AI Inside: 
https://a16z.com/vertical-saas-now-with-ai-inside/ • BarbAIrians at the Gate: The Financial Opportunity of AI: 
https://a16z.com/financial-opportunity-of-ai/
Stay Updated:

 • Let us know what you think: 
https://ratethispodcast.com/a16z • Find a16z on Twitter: 
https://twitter.com/a16z • Find a16z on LinkedIn: 
https://www.linkedin.com/company/a16z • Subscribe on your favorite podcast app: 
https://a16z.simplecast.com/ • Follow our host: 
https://twitter.com/stephsmithio
Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.a

How AI is Transforming Labor Markets

In this episode of Web3 with a16z, Shopify CEO and cofounder Tobias Lütke joins a16z cofounder Ben Horowitz for a conversation recorded live at the a16z crypto Founders Summit.

Together, they explore what it takes to build a breakout startup in a competitive market, the changing landscape of retail, and how to drive workplace change while navigating corporate culture and calls for activism.

Tobias shares the story behind Shopify's growth from a snowboarding store to a global ecommerce platform serving millions of merchants, discusses the moral imperative of creating great software, and offers insights on leadership, innovation, and embracing negativity as a tool for progress.

The episode also touches on the intersection of AI and crypto, the power of decentralization, and the next wave of technologies reshaping business and commerce.

 

Resources:

Find Ben on X: https://x.com/bhorowitz

Find Toni on X: https://x.com/tobi

 

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Scaling Shopify: Tobias Lütke and Ben Horowitz on Building a Global Giant

As 2025 begins, industries are evolving at unprecedented speed: robots are revolutionizing manufacturing, terabytes of earth observation data are driving new possibilities, and gaming technology is transforming how we design, train, and innovate across sectors.

In this episode, a16z General Partner Erin Price-Wright, Engineering Fellow Millen Anand, and Partner Troy Kirwin discuss the trends reshaping the future of hardware, software, and beyond.

We explore:

 • How robots and full-stack engineers are driving the next industrial renaissance.
 • The explosion of Earth observation data and its potential to revolutionize industries.
 • How gaming technology is moving beyond entertainment to reshape training, design, and more.

This is just the beginning of our four-part series on 50 Big Ideas for 2025—don’t miss the full list at a16z.com/bigideas.

Resources: 

Find Erin on X: https://x.com/espricewright

Find Millen on LinkedIn: https://www.linkedin.com/in/millen-anand/

Find Troy on X: https://x.com/tkexpress11

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Jobs of the Future, Harnessing Earth Observation, & Gaming Tech Advances

The AI race is on, and 2025 could be its most transformative year yet.

In this episode, a16z General Partners Anjney Midha and Jennifer Li, and Partner Alex Immerman dive into the trends reshaping AI and its impact on search, infrastructure, and devices.

We explore:

 • How AI-native tools like ChatGPT and Perplexity are challenging Google’s search dominance.
 • The rise of infrastructure independence as governments prioritize compute, energy, and data.
 • The future of smaller, on-device AI models driving privacy, performance, and new consumer applications.

With insights from a16z’s Growth and Infrastructure teams, this episode unpacks the forces driving AI innovation—and the opportunities founders and nations could seize to lead in the next wave of technology.

Stay tuned for more in this four-part series, and explore the full 50 Big Ideas for 2025 at a16z.com/bigideas.

Resources: 

Find Alex on X: https://x.com/aleximm

FInd Anjney on X: https://x.com/AnjneyMidha

FInd Jennifer on X: https://x.com/JenniferHli

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The Race for AI—Search, National Infrastructure, & On-Device AI

As we prepare to step into 2025, the possibilities for applied AI are reshaping industries in profound ways.

 In this episode, a16z General Partners Julie Yoo and Angela Strange, and Partner Joe Schmidt, dive into the transformative power of AI across healthcare, fintech, and traditional service sectors.

We explore:

 • Super Staffing for Healthcare: How AI can address critical clinical labor shortages and augment care delivery at scale.
 • Regulation Becomes Code: The potential for AI to simplify and streamline compliance, making systems safer and more efficient.
 • Romanticizing Inorganic Growth: The opportunity for AI-powered startups to redefine service industries through workflow automation and strategic acquisition.

With insights from a16z’s Bio + Health, Fintech, and Apps teams, this episode unpacks the ideas that will revolutionize traditional systems and unlock opportunities in 2025.

Check out the full 50 Big Ideas for 2025 at a16z.com/bigideas.

 

Resources: 

Find Angela on X: https://x.com/astrange

Find Julie on X: https://x.com/julesyoo

Find Joe on X: https://x.com/joeschmidtiv

Link to article 'The Messy Inbox Problem: Wedge Strategies in AI Apps': https://a16z.com/the-messy-inbox-problem-ai-apps-wedge-strategies

 

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Super Staffing Healthcare, Codifying Compliance, & Scaling Services

with @sambroner @meigga @darenmatsuoka @jneu_net @chrislyons and @rhhackett @smc90

Welcome to our special end-of-year episodes -- which also look ahead to 2025 -- covering our annual Big Ideas lists, where various a16z crypto team members share what they are personally excited about. (You can see the firmwide list, also including all the trends of the crypto team, here.)

This episode is part 1 of 2 -- but you don't have to listen to them in any particular order -- covering the trends and themes of:

 • stablecoins, payments, and where the early adopters will come from;
 • app store distribution, curation, and discovery;
 • where the next crypto users will come from, turning passive holders into active users;
 • how builders improve, and better choose, infrastructure; and
 • simplifying user experience.

 Covering each of these -- and coming from the investing, go-to-market, data science, research, and media teams are: Sam Broner, Maggie Hsu, Daren Matsuoka, Joachim Neu, and Chris Lyons; in conversation with hosts Sonal Chokshi and Robert Hackett. (Stay tuned until the end for some of our meta-commentary.) 

These are just 5 of the 14 trends we shared; you can check out the full list at a16zcrypto.com/bigideas.

Also be sure to check out part 2, which covers all the trends at the intersection of crypto and AI. 

As a reminder, none of the content is investment, business, legal, or tax advice; please see a16z.com/disclosures for more important information -- including a link to a list of our investments.

Crypto Trends for 2025: Stablecoins, App Stores, UX, and More

In this episode, Substack cofounder and CEO Chris Best joins a16z General Partner Andrew Chen to discuss the origins and evolution of Substack, a platform redefining media and empowering creators to connect directly with their audiences. They dive into how Substack’s early days led to over 3 million paid subscribers, why creators are moving away from traditional platforms to establish direct connections with their audiences, and how the future of media in the AI era is reshaping opportunities for writers, podcasters, and video creators.

From Chris’s lessons scaling Kik Messaging to Substack’s profound impact on the creator economy, this conversation shares insights on building platforms, culture, and opportunity in the modern era.

 

Resources: 

Find Chris on Substack: https://cb.substack.com/

Find Andrew Chen on Substack: https://andrewchen.substack.com/

 

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Building Substack: Reinventing Culture through Subscriptions

Healthcare is a $4 trillion industry, making up nearly a fifth of the U.S. economy—but despite having some of the best doctors and advanced technology, the system often delivers poor outcomes at skyrocketing costs. Why is this the case, and what will it take to fix it?

In this episode, a16z cofounder Marc Andreessen and General Partners Vijay Pande and Julie Yoo tackle some of the biggest questions shaping the future of healthcare:

 • Is the solution to our healthcare crisis a policy, technology, or competition problem?
 • Will AI and technology transform the industry, or are regulatory and structural barriers too entrenched?
 • Who will crack the code—healthcare incumbents, tech giants, or AI-native startups?

From chronic care to cost curves, from disruptive technologies to shifting patient agency, this conversation offers an unfiltered look at what’s broken in the healthcare system and how it might finally change.

Resources: 

Find Marc on X: https://x.com/pmarca

Find Vijay on X: https://x.com/vijaypande

Find Julie on X: https://x.com/julesyoo

The Biggest Company in the World

Why Will Healthcare be the Industry that Benefits Most from AI?

Grand Challenges in Healthcare AI with Vijay Pande and Julie Yoo

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Marc Andreessen: Can Tech Finally Fix Healthcare?

Intelligent automation is transforming industries by tackling messy, unstructured workflows that traditional Robotic Process Automation (RPA) couldn’t handle. In this episode, a16z partner Kimberly Tan discusses the shift from rigid RPA systems to AI-powered agents and why this evolution unlocks massive opportunities in legacy markets.

Drawing on her article "RIP to RPA: The Rise of Intelligent Automation," Kimberly shares real-world examples of companies revolutionizing referral management, and highlights how startups can build impactful solutions in this space.

Resources:

Find Kimberly on X: https://x.com/kimberlywtan

Read Kimberly’s article: https://a16z.com/rip-to-rpa-the-rise-of-intelligent-automation/

Stay Updated: 

Let us know what you think: https://ratethispodcast.com/a16z

Find a16z on Twitter: https://twitter.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Subscribe on your favorite podcast app: https://a16z.simplecast.com/

Follow our host: https://twitter.com/stephsmithio

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

RIP to RPA: How AI Makes Operations Work

How does the world’s largest producer of medicines in terms of volume balance the science and the business of innovation? How does an enterprise at such vast scale make decisions about what to build vs. buy, especially given the fast pace of science today? How does it balance attitudes between “not invented here” and “not invented yet”?

Vas Narasimhan, CEO of Novartis, sat down with a16z bio general partners Jorge Conde and Vijay Pande, and editor in chief Sonal Chokshi, during the JP Morgan Healthcare Conference around this time last year, to discuss the latest trends in therapeutics; go to market and why both big companies and bio startups need to get market value signals (not just approvals!) from payers earlier in the process; clinical trials, talent, leadership, and more in this rerun of the a16z Podcast.

 

image: Global Panorama/ Flickr

On Pharma Trends and Big Company Innovation

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