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Andreessen Horowitz

The a16z Podcast discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!

a16z Podcast

Scaling laws took us from GPT-1 to GPT-5 Pro. But in order to crack physics, we’ll need a different approach. 

In this episode, a16z General Partner Anjney Midha talks to Liam Fedus, former VP of post-training research and co-creator of ChatGPT at OpenAI, and Ekin Dogus Cubuk, former head of materials science and chemistry research at Google DeepMind, on their new startup Periodic Labs and their plan to automate discovery in the hard sciences.

Follow Liam on X: https://x.com/LiamFedus

Follow Dogus on X: https://x.com/ekindogus

Learn more about Periodic: https://periodic.com/

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Follow our host: https://twitter.com/eriktorenberg

 

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

 
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Building an AI Physicist: ChatGPT Co-Creator’s Next Venture

Ads pay for the internet—and they’re about to change again. a16z General Partner Erik Torenberg, entrepreneur and author Antonio García Martínez, and Meta CMO Alex Schultz dive into growth and performance marketing, privacy myths, retail media, and the AI future of “audience-of-one” advertising—plus Instagram what-ifs, WhatsApp as a super-app, and how Meta’s feed shifted from social graphs to AI-ranked content.

 

Timecodes:

0:00 Introduction 
0:38 Book Inspiration & Positive Perspective on Advertising
4:43 Critiques of Online Advertising & Data Privacy
7:34 The Evolution of Media Business Models
10:12 Content Moderation and Platform Shifts
11:43 Connected vs. Unconnected Content & The Rise of AI
13:34 The Future of AI, Personalization, and Advertising
28:18 Retail Media Networks & First-Party Data
38:18 Alternative Histories: Instagram, Libra, and Industry What-Ifs
46:31 The Impact of AI on Jobs and Company Structure
55:00 The Metaverse, VR, and Future Platforms

Resources:

Make sure to get Alex’s book here!

Follow Alex on X: https://x.com/alexschultz

Follow Alex on Facebook: https://www.facebook.com/alexschultz

Follow Alex on Threads: https://www.threads.com/@alexorig

Follow Antonio on X: https://x.com/antoniogm

 

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Find a16z on X: https://x.com/a16z

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Listen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX

Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711

Follow our host: https://x.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

 

 

Stay Updated:

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Follow our host: https://twitter.com/eriktorenberg

 

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

 
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Meta CMO: How Advertising Works Under the Hood

Announcing our new show, Monitoring the Situation, hosted by a16z General Partners Erik Torenberg and Katherine Boyle, with guest Eddie Lazzarin, CTO of a16z crypto. 

In this first episode, we ask how American Dynamism, consumer, games, and crypto all fit together, from Palmer/Oculus to Marc Andreessen’s Techno-Optimist Manifesto, while also exploring crypto × AD values, parenting in the AI era, and how internet subcultures shape the news.

 

Timecodes: 

0:00 Introduction

1:25 Tech Coherence: American Dynamism & Consumer Crypto

4:55 The Hero’s Journey in Tech

5:59 Games, Toys, and Defense Innovation

6:38 Crypto & American Values

11:25 Decentralization, Federalism, and Tech

13:08 AI, China, and Competing Values

14:18 Medicine, Parenting, and the Wisdom of Crowds

20:47 ADHD, Diagnosis Incentives, and Education

27:31 Alternative Schooling & AI Tutors

35:46 Parenting, Family, and Modern Support Systems

42:24 Zoomer Culture, Internet Fragmentation, and X

54:38 Media, Social Networks, and Cultural Shifts

 

Resources: 

Find Eddy on X: https://x.com/eddylazzarin

Find Katherine on X: https://x.com/KTmBoyle

Find Erik on X: https://x.com/eriktorenberg

 

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If you enjoyed this episode, be sure to like, subscribe, and share with your friends!

Find a16z on X: https://x.com/a16z

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Listen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX

Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711

Follow our host: https://x.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Stay Updated:

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Follow our host: https://twitter.com/eriktorenberg

 

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

 
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The Common Thread of All Technology: Monitoring the Situation, Ep.1

What comes after vibe coding? Maybe vibe researching.

OpenAI’s Chief Scientist, Jakub Pachocki, and Chief Research Officer, Mark Chen, join a16z general partners Anjney Midha and Sarah Wang to go deep on GPT-5—how they fused fast replies with long-horizon reasoning, how they measure progress once benchmarks saturate, and why reinforcement learning keeps surprising skeptics.

They explore agentic systems (and their stability tradeoffs), coding models that change how software gets made, and the bigger bet: an automated researcher that can generate new ideas with real economic impact. Plus: how they prioritize compute, hire “cave-dweller” talent, protect fundamental research inside a product company, and keep pace without chasing every shiny demo.

 

Timecodes: 

0:00 Introduction & Goals of Automated Researcher

0:43 The Evolution of Reasoning in AI

1:46 Evaluations: From Benchmarks to Real-World Impact

5:15 Surprising Capabilities of GPT-5

6:56 The Research Roadmap: Next 1, 2, 5 Years

7:46 Long-Horizon Agency & Model Memory

9:44 Reasoning in Open-Ended Domains

11:18 The Role and Progress of Reinforcement Learning

13:14 Reward Modeling & Best Practices

14:21 The New Codex: Real-World Coding

16:20 AI vs. Human Coding: The New Default

20:07 What Makes a Great Researcher?

21:14 Persistence, Conviction, and Problem Selection

26:00 Building and Sustaining a Winning Research Culture

31:45 Balancing Product and Fundamental Research

39:00 The Importance of Compute and Physical Constraints

45:50 Maintaining Speed and Learning at Scale

47:18 Trust and Collaboration at OpenAI

 

Resources: 

Find Jakub on X: https://x.com/merettm

Find Mark on X: https://x.com/markchen90

Find Sarah on X: https://x.com/sarahdingwang

Find Anjney on X: https://x.com/AnjneyMidha

 

Stay Updated: 

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Find a16z on X: https://x.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Listen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX

Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711

Follow our host: https://x.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Stay Updated:

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Follow our host: https://twitter.com/eriktorenberg

 

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

 
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

From Vibe Coding to Vibe Researching: OpenAI’s Mark Chen and Jakub Pachocki

Should the US put a price on H-1B visas, or would that block the flow of new talent? Are AI coding agents actually making teams way more productive, or is it just hype? And in the AI platform shift, will the big winners be incumbents or new AI-native startups?

Erik Torenberg is joined by Box co-founder and CEO Aaron Levie, a16z board partner Steven Sinofsky, and a16z general partner Martin Casado to debate the biggest questions in tech. They unpack pricing vs lottery for H-1Bs and what we’re actually optimizing for, why Box now ships a third of its code from AI, the shift from writing to reviewing code, and why bottom-up personal AI tools succeed where top-down “AI pilots” struggle.

 

Timecodes: 

0:00 Introduction

1:07 Latest immigration policy and who benefits

1:39 Debating the Price on H-1B Visas

2:11 Startups vs. Big Tech: Who Benefits from Policy?

2:31 Market Dynamics and Wage Impacts

3:44 The Lottery System and Startup Challenges

12:25 Labor Markets to Labor Productivity with AIs

14:47 Startups Achieving 10x Productivity with AI

16:43 Early Adopters, Hype, and Measuring Productivity

33:50 AI’s Impact on Professional and Creative Work

37:56 The Rise of AI-Native Startups

40:58 Platform Shifts: Startups vs. Incumbents

42:12 Disruption, Incumbents, and New Opportunities

53:00 The Future of Work and AI Adoption

54:38 Brand Effects and Early Leaders in AI

55:22 Will Incumbents or Newcomers Win the AI Race?

Resources:

Find Aaron on X: https://x.com/levie

Find Steven on X: https://x.com/stevesi

Find Martin on X: https://x.com/martin_casado

Find Erik on X: https://x.com/eriktorenberg

 

Stay Updated: 

If you enjoyed this episode, be sure to like, subscribe, and share with your friends!

Find a16z on X: https://x.com/a16z

Find a16z on LinkedIn: https://www.linkedin.com/company/a16z

Listen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX

Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711

Follow our host: https://x.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Stay Updated:

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Follow our host: https://twitter.com/eriktorenberg

 

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

 
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Software finally eats services - Aaron Levie

Dr. Jay Bhattacharya is one of the country’s top medical experts and a 24-year professor of medicine at Stanford. After being censored and deplatformed during COVID for his role in opposing harsh lockdowns, he was appointed Director of the National Institutes of Health by President Trump in 2025.

a16z General Partners Erik Torenberg, Vineeta Agarwala, and Jorge Conde join Dr. Bhattacharya to discuss the administration’s role in tackling the autism crisis, how to restore public trust in health authorities, how to make the NIH more dynamic and efficient, and how to streamline publishing and restore academic freedom.

Timecodes: 

0:00 Introduction
1:30 Autism Initiative & New Research
2:45 Drug Discoveries: Leucovorin & Tylenol Caution
4:35 Preterm Birth & Broader Health Initiatives
5:45 The Replication Crisis in Science
8:50 Reforming NIH Funding & Scientific Culture
14:00 Allocation vs. Execution at NIH
17:30 Political & Scientific Decision-Making
22:30 Addressing Life Expectancy & Chronic Disease
27:00 Supporting Early Career Investigators
34:50 Academic Freedom & Open Science
37:30 Rebuilding Public Trust in Public Health
41:00 Communicating Science Amid Uncertainty
47:50 NIH Priorities: Nutrition, Chronic Disease, AI
50:00 The Future of AI in Science & Medicine
53:30 Advice for Rising Scientists
55:00 The Role and Limits of AI in Science

 

Resources:

Find Dr. Bhattacharya on X: https://x.com/DrJBhattacharya and https://x.com/NIHDirector_Jay

Find Erik on X: https://x.com/eriktorenberg

Find Jorge on X: https://x.com/JorgeCondeBio

Find Vineeta on X: https://x.com/vintweeta

Learn more about the NIH: https://www.nih.gov/

Stay Updated:

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Follow our host: https://twitter.com/eriktorenberg

 

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

 
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

America's Autism Crisis and How AI Can Fix Science with NIH Director Jay Bhattacharya

Nvidia’s $5 billion investment in Intel is one of the biggest surprises in semiconductors in years. Two longtime rivals are now teaming up, and the ripple effects could reshape AI, cloud, and the global chip race.

To make sense of it all, Erik Torenberg is joined by Dylan Patel, chief analyst at SemiAnalysis, joins Sarah Wang, general partner at a16z, and Guido Appenzeller, a16z partner and former CTO of Intel’s Data Center and AI business unit. Together, they dig into what the deal means for Nvidia, Intel, AMD, ARM, and Huawei; the state of US-China tech bans; Nvidia’s moat and Jensen Huang’s leadership; and the future of GPUs, mega data centers, and AI infrastructure.

 

Resources: 

Find Dylan on X: https://x.com/dylan522p

Find Sarah on X: https://x.com/sarahdingwang

Find Guido on X: https://x.com/appenz

Learn more about SemiAnalysis: https://semianalysis.com/dylan-patel/

 

Stay Updated: 

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Find a16z on X: https://x.com/a16z

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Listen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX

Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711

Follow our host: https://x.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Stay Updated:

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Follow our host: https://twitter.com/eriktorenberg

 

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

 
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Dylan Patel on the AI Chip Race - NVIDIA, Intel & the US Government vs. China

In this episode of Honestly with Bari Weiss, we share a special conversation featuring a16z general partner Katherine Boyle in the wake of Charlie Kirk’s shocking assassination.

Katherine reflects on what courage means in a culture where words and debate are increasingly met with violence. Drawing on faith, history, and her own response to recent tragedies, she discusses the idea of martyrdom, not only in its most extreme sense, but also in the small, everyday choices to speak the truth despite risk.

 

Timecodes: 

0:00 Introduction 

0:49 Remembering Charlie Kirk

2:46 The Meaning of Martyrdom

4:49 Courage and the Choice We Face

9:16 Returning to Normalcy

10:35 The Age of Extremes

12:15 Words, Violence, and the Next Generation

14:10 Reclaiming the Center

18:18 The Power and Danger of Rhetoric

21:55 The Call to Speak Up

 

Resources: 

Listen to more from Honestly: https://podcasts.apple.com/za/podcast/honestly-with-bari-weiss/id1570872415

Find Bari on X: https://x.com/bariweiss

Find Katherine on X: https://x.com/KTmBoyle

 

Stay Updated: 

If you enjoyed this episode, be sure to like, subscribe, and share with your friends!

Find a16z on X: https://x.com/a16z

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Listen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX

Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711

Follow our host: https://x.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Stay Updated:

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Follow our host: https://twitter.com/eriktorenberg

 

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

 
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Charlie Kirk and the Rise of Political Violence

The web is unhealthy, and AI agents are about to rewrite how we shop.

In this episode, a16z General Partner Alex Rampell and Partner Justine Moore explore how AI agents will change commerce and the implications for Google’s business model, affiliate marketing, online shopping, and more.

 

Timecodes: 

0:00 Introduction 

0:12 The Role of AI Agents in Commerce

1:28 Affiliate Marketing & Impulse Buys

4:02 Observing Consumer Behavior & AI

6:08 Dynamic Pricing & E-commerce Trends

7:20 Online vs. Offline Shopping Behaviors

10:09 The Challenge of Attribution in Commerce

12:19 Aggregators, Brands, and Business Models

15:24 Trend Cycles & Single SKU Retailers

17:49 Google, Search, and the Freemium Model

22:41 The Unhealthy Web & Commercialization

26:04 Video Reviews & Trust in Commerce

29:10 The Costco Model & Consumer Trust

33:15 AI’s Impact on Different Types of Purchases

39:56 The Future: Specialized Shopping Agents

40:16 Opportunities for New Durable Companies

44:18 The Merchant Side: Infrastructure for AI Agents

 

Resources: 

Read the article: http://a16z.com/ai-x-commerce/

Find Alex on X: https://x.com/arampell

Find Justine on X: https://x.com/venturetwins

 

Stay Updated: 

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Find a16z on X: https://x.com/a16z

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Listen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX

Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711

Follow our host: https://x.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Stay Updated:

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Follow our host: https://twitter.com/eriktorenberg

 

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

 
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The Death of Search: How Shopping Will Work In The Age of AI

OpenAI’s Codex has already shipped hundreds of thousands of pull requests in its first month. But what is it really, and how will coding agents change the future of software?

In this episode, General Partner Anjney Midha goes behind the scenes with one of Codex’s product leads- Alexander Embiricos - to unpack its origin story, why its PR success rate is so high, the safety challenges of autonomous agents, and what this all means for developers, students, and the future of coding.

 

Timecodes:

0:00 Intro: The Vision for AI Agents

1:25 Codex’s Origin and Naming

3:20 Early Prototypes and Agent Form Factors

6:00 Cloud Agents: Safety and Security

9:40 Prompt Injection and Attack Vectors

12:00 PR Merging: Metrics and Transparency

17:00 The Future of Code Review and Automation

20:00 User Adoption: Internal vs. External Surprises

22:00 Multi-Turn Interactions and Product Learnings

29:30 Best-of-N, Slot Machine Analogy, and Creativity

33:00 Human Taste, Iteration, and Collaboration

40:00 AI’s Impact on Software Engineering Careers

45:00 Education, CS Degrees, and AI Integration

49:00 Prototyping, Hackathons, and Speed to Magic

55:00 Legacy Code, Modernization, and Global Adoption

1:00:00 Enterprise, Security, and Air-Gapped Environments

1:05:00 Product Roadmap and Future of Codex

1:10:00 Advice for Founders and Startups

1:15:00 Education Reform and Project-Based Learning

1:20:00 Hiring, Building, and New Grad Advice

 

Resources: 

Find Alex on X: https://x.com/embirico

Find Anjney on X: https://twitter.com/AnjneyMidha

 

Stay Updated: 

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Find a16z on X: https://x.com/a16z

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Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711

Follow our host: https://x.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

 
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How OpenAI Built Its Coding Agent

Can we make science as fast as software? 

In this episode, Erik Torenberg talks with Patrick Hsu (cofounder of Arc Institute) and a16z general partner Jorge Conde about Arc’s “virtual cells” moonshot, which uses foundation models to simulate biology and guide experiments. 

They discuss why research is slow, what an AlphaFold-style moment for cell biology could look like, and how AI might improve drug discovery. The conversation also covers hype versus substance in AI for biology, clinical bottlenecks, capital intensity, and how breakthroughs like GLP-1s show the path from science to major business and health impact.

 

Resources:

Find Patrick on X: https://x.com/pdhsu

Find Jorge on X: https://x.com/JorgeCondeBio

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