This December 1st, Project HOPE was among the many organizations commemorating World AIDS Day as well as the 16 Days of Activism Against Gender-Based Violence. Over two decades, significant progress in HIV control, particularly in Africa, has been achieved through initiatives like President’s Emergency Plan for AIDS Relief (PEPFAR). Since 2003, PEPFAR has enabled over 20 million people to access antiretroviral therapy and prevented 5.5 million HIV-positive births. However, challenges persist in meeting UNAIDS' 95-95-95 targets—ensuring widespread testing, treatment, and viral suppression. Barriers include funding shortages, stigma, and competing health crises like COVID-19. Adolescents, especially girls and young women, face heightened risk due to social vulnerabilities and limited access to youth-friendly services. Mvemba is joined by Dr. Uche Ralph-Opara, Chief Health Officer at Project HOPE, to discuss the progress made and the hurdles that remain in achieving epidemic control. Their conversation highlights innovative approaches to addressing gender inequality and empowering vulnerable populations.