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Medscape

This podcast delivers Dr. John Mandrola's summary and perspective on top news of the week that cardiologists can't miss. This podcast is intended for US health professionals only.

This Week in Cardiology

A second ESC recap plus two breaking stories on the failure of an investigational Lp(a) reducing drug and a new FDA approval of an AI-ECG app are covered by John Mandrola, MD
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Lp(a) Disappointment
 
 HORIZON https://clinicaltrials.gov/study/NCT04023552 Press Release https://www.novartis.com/news/media-releases/novartis-announces-lpahorizon-phase-iii-topline-results-pelacarsen-patients-elevated-lpa-and-established-cardiovascular-disease-cvd Rationale paper https://doi.org/10.1016/j.ahj.2025.03.019 
II FDA Clears AI-ECG for Acute MI Detection 
 
 • Accuracy of cath lab activation decisions for STEMI-equivalent and mimic ECGs: Physicians vs. AI (Queen of Hearts by PMcardio) 10.1016/j.ajem.2025.07.061
 • AI-Enabled ECG Analysis Improves Diagnostic Accuracy and Reduces False STEMI Activations: A Multicenter U.S. Registry https://www.jacc.org/doi/10.1016/j.jcin.2025.10.018
 • Queen of Hearts™ AI ECG App https://www.powerfulmedical.com/pmcardio-stemi/
 
III TARGET CTCA Trial
 
 • Targeted Use of Computed Tomographic Coronary Angiography in Acute Chest Pain https://www.nejm.org/doi/10.1056/NEJMoa2608903
 
IV CorCal trial
 
 Press release • 
https://www.escardio.org/news/press/press-releases/new-data-presented-on-the-use-of-coronary-artery-calcium-for-cardiovascular-risk-assessment/ • CorCal Outcomes: A randomized trial using the pooled cohort equation or coronary artery calcium to select statin therapy in primary prevention patients. Study design and baseline characteristics 
https://doi.org/10.1016/j.ahj.2026.107473 
V AMUNDSEN Trial
 
 • LDL Cholesterol Lowering With Evolocumab Before Percutaneous Coronary Intervention for Acute Myocardial InfarctionThe AMUNDSEN Randomized Clinical Trial 
https://jamanetwork.com/journals/jama/fullarticle/2853274 
VI TRIC-I-HF trial
 
 • Tricuspid Repair Cuts Death, HF Hospitalization in Severe TR 
https://www.medscape.com/viewarticle/tricuspid-repair-cuts-death-hf-hospitalization-severe-tr-2026a1000wvk • Tricuspid-Valve Intervention in Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa2606934
 
You May Also Like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
 Questions or feedback, please contact news@medscape.net

Sep 11 2026 This Week in Cardiology

ESC recaps on the SINGLE-AF trial, CMR Guide trial, two ATTR studies, PVI-SHAM-AF, STAREE, and an observational study of ICD benefit over the past decades are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I SINGLE-AF Trial
 
To Anticoagulate or Not in Intermediate-Risk AF: The SINGLE-AF Trial https://www.medscape.com/viewarticle/anticoagulate-or-not-intermediate-risk-af-single-af-trial-2026a1000uko
 
 SINGLE-AF https://www.nejm.org/doi/10.1056/NEJMoa2607978 
II Scar as an ICD risk stratifier
 
Is Scar on CMR an Indication for ICD? CMR Guide Leaves Doubts
 
 https://www.medscape.com/viewarticle/scar-cmr-indication-icd-cmr-guide-leaves-doubts-2026a1000ukq
 
 CMTR GUIDE Trial • 
https://jamanetwork.com/journals/jama/fullarticle/2853395 MADIT II Trial • 
https://www.nejm.org/doi/full/10.1056/NEJMoa013474 
III Single vs Dual Therapy in ATTR-CM
 
 HELIOS-B Trial Sub-analysis • 
https://www.sciencedirect.com/science/article/pii/S0735109726072086 HELIOS-B Sub-analysis Editorial • 
https://www.sciencedirect.com/science/article/pii/S0735109726073766#bib8 HELIOS-B main trial • 
https://www.nejm.org/doi/10.1056/NEJMoa2409134 CARDIO-TTRansform Trial • 
https://www.nejm.org/doi/full/10.1056/NEJMoa2608510 
IV A Stunning Result of another Sham-controlled AF ablation trial
 
Does AF Ablation Work? That's in Question After PVI-SHAM-AF https://www.medscape.com/viewarticle/does-af-ablation-work-s-question-after-sham-pvi-af-2026a1000uli
 
 PVI-SHAM-AF Trial • 
10.1016/S0140-6736(26)01558-8 External Link SHAM-PVI Trial • 
https://jamanetwork.com/journals/jama/fullarticle/2823283 PFA-Sham Trial • 
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079484 
V Should Older Adults Take Statins: The STAREE trial.
 
STAREE Strengthens Case for Over-the-Counter Statins https://www.medscape.com/viewarticle/staree-strengthens-case-over-counter-statins-2026a1000vrw
 
 STAREE Trial • 
https://www.nejm.org/doi/full/10.1056/NEJMoa2607314 
VII Declining ICD Benefit After MI 
 
 Mortality Reduction with ICD for Prevention of SCD Post-MI • 
https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag706/8768943 • 
 CONTEMP-ICD Trial https://clinicaltrials.gov/study/NCT06543446 • 
 PROFID-EHRA Trial https://profid-project.eu/profid-ehra-trial/ • 
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Sep 04 2026 This Week in Cardiology

Listener feedback on mechanical CPR devices, PFA and stroke, the Lindy effect in adopting new technology, and an ESC preview are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Listener Feedback on Mechanical Compression Devices for OHCA
 
 
 Mechanical CPR Device Use and Cardiac Arrest Survival 
 https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079272
 
 PARAMEDIC trial • https://www.thelancet.com/article/S0140-6736(14)61886-9/fulltext
 CIRC trial • https://www.resuscitationjournal.com/article/S0300-9572(14)00128-2/fulltext
 LINC trial • https://jamanetwork.com/journals/jama/fullarticle/1774037
 Cochrane Review • 
– Mechanical vs Manual Chest Compressions for Cardiac Arrest • https://pmc.ncbi.nlm.nih.gov/articles/PMC6953326/
 
II PFA and Stroke
 
 Risk of Stroke and TIA With PFA vs RF Ablation https://www.ahajournals.org/doi/epub/10.1161/CIRCULATIONAHA.126.081092 AVANT GUARD Trial https://www.nejm.org/do/10.1056/NEJMdo008538/full/ EMBOL-AF Registry https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag217/8566008 
III A New ICD Lead
 
 LEADR LBBAP • 
Trial • https://doi.org/10.1016/j.hrthm.2026.08.030
 
IV ESC Preview
 
 Mandrola's Preview of the European Society of Cardiology 2026 https://www.medscape.com/viewarticle/mandrolas-preview-european-society-cardiology-2026-2026a1000tfi 
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Aug 28 2026 This Week in Cardiology

Mechanical CPR devices, the dangers of AF performance measures, two scholarly articles on CLOSURE and CHAMPION, and a little ESC preview are the topics John Mandrola, MD, discusses in this week's podcast. 
 
 This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Mechanical Compression Devices for OHCA
 
 
 
 · Mechanical CPR Device Use Cardiac Arrest Survival
 
 https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079272
 
 · PARAMEDIC Trial https://www.thelancet.com/article/S0140-6736(14)61886-9/fulltext
 
 · CIRC Trial https://www.resuscitationjournal.com/article/S0300-9572(14)00128-2/fulltext
 
 · LINC trial https://jamanetwork.com/journals/jama/fullarticle/1774037
 
 · Cochrane Review of Mechanical vs Manual Chest Compressions for Cardiac Arrest https://pmc.ncbi.nlm.nih.gov/articles/PMC6953326/
 
II ACC AF Performance Measures
 
 · 2026 AHA/ACC Clinical Performance for Patients With AF https://www.jacc.org/doi/10.1016/j.jacc.2026.05.032#sec-3
 
III Two Critical Appraisals of the recent LAAC trials
 
 · Reappraising CHAMPION-AF 10.1016/j.hrthm.2026.07.048 External Link
 
 · CHAMPION and CLOSURE: Reconciling Contrast Results https://doi.org/10.1093/eurheartj/ehag608
 
ESC Early Preview
 
 · CMR Guide trial https://pmc.ncbi.nlm.nih.gov/articles/PMC6931571/
 
 · SINGLE AF Trial 10.1016/j.hroo.2025.12.008 External Link
 
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 The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
 Questions or feedback, please contact news@medscape.net

August 21 2026 This Week in Cardiology

Listener feedback, the ZEUS trial fails, a fascinating statin trial, more on GLP-1 drugs, and radiation safety in the EP lab are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I ZEUS Fails
 
Rethinking Inflammation and ASCVD: Four Lessons From the ZEUS Trial
 
 https://www.medscape.com/viewarticle/rethinking-inflammation-and-ascvd-four-lessons-zeus-trial-2026a1000rlm
 
 ZEUS Trial • 
https://doi.org/10.1001/jamacardio.2025.4491 
II Statins and the Elderly
 
 SAGA/SITE trial • 
10.1016/j.lanhl.2026.100884 External Link 
III GLP-1 and CV Risk
 
 SURMOUNT-1 Trial • 
https://www.nejm.org/doi/10.1056/NEJMoa2206038 SURMOUNT-1 Post Hoc Analysis • 
https://www.jacc.org/doi/10.1016/j.jacc.2026.04.044 Reframing GLP-1s as Cardiometabolic Health Drugs: Editorial • 
https://www.jacc.org/doi/10.1016/j.jacc.2026.06.039 
IV Radiation Exposure to the Uterus in the EP Lab
 
 Occupational Radiation Safety in EP During Pregnancy • 
https://www.ahajournals.org/doi/epub/10.1161/CIRCULATIONAHA.126.080556 Survey: Working in Cath Lab During Pregnancy • 
https://www.surveymonkey.com/share/d5c1edf7-6d99-49d4-a9fa-e9168f63ab55 
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Aug 14 2026 This Week in Cardiology

Another failure of LA posterior wall isolation, first-line AF ablation, a revelation on EAST-AFNET 4 trial, an LAAC meta-analysis, and preventing AKI post-cardiac surgery are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Listener Feedback
 
 DAPT-MVD Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2517588 
II Another Failure of Posterior Wall Isolation
 
 CORNERSTONE-AF Trial • 
https://doi.org/10.1093/eurheartj/ehag486 CAPLA Trial • 
https://jamanetwork.com/journals/jama/fullarticle/2800186 PVIOTAL IDE Trial • 
10.1016/j.hrthm.2025.08.018 External Link 
III First Line AF ablation – One new study and a discovery about a second one
 
 Catheter Ablation vs AAD for First-line Treatment of AF • 
10.1016/j.hrthm.2025.07.061 External Link EAST-AFNET 4 Trial • 
https://www.nejm.org/doi/full/10.1056/NEJMoa2019422 Cardiology Trials Substack • 
https://cardiologytrials.substack.com/p/summary-and-discussion-of-east-afnet 
IV Left Atrial Appendage Closure Meta-analysis
 
 Long-Term Efficacy and Safety of LAAC vs OAC -- Meta-analysis • 
https://academic.oup.com/europace/article/28/7/euag159/8739567 
V Prevention of AKI after Cardiac Surgery: MERCURI-2
 
 MERCURI-2 Study • 
https://jamanetwork.com/journals/jama/fullarticle/2852324 
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Jul 31 2026 This Week in Cardiology

The first oral PCSK9 inhibitor, another study finding safe MRI scanning in patients with nonconditional CIEDs, the PFA-SHAM trial, and the curious case of orthopedic injuries in cardiology are the topics John Mandrola, MD, discusses in this week's podcast.
 
 This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
 
 
I Enlicitide Approved
 
First Oral PCSK9 Inhibitor Welcomed for Potential Primary Care Impact https://www.medscape.com/viewarticle/first-oral-pcsk9-inhibitor-welcomed-potential-primary-care-2026a1000own
 
 • 
Dr Gregory Katz Substack • 
https://gregorykatz.substack.com/p/are-we-sure-mercks-new-cholesterol • 
CORALreef Lipids Trial • 
https://www.nejm.org/doi/full/10.1056/NEJMoa2511002 • 
CORALreef HeFH Trial • 
https://jamanetwork.com/journals/jama/fullarticle/2841258 • 
CORALreef Outcomes Trial • 
https://clinicaltrials.gov/study/NCT06008756 
 II MRI Scans in Non-conditional CIEDs
 
 Specialized Nurse Practitioners Safely Manage MRI in Patients With Cardiac Implantable Devices https://www.medscape.com/viewarticle/specialized-nurse-practitioners-safely-manage-mri-patients-2026a1000ozt
 
 Nurse Practitioner-Led CIED Monitoring During MRI • 
10.1016/j.hroo.2026.04.031 External Link MRI in Nonconditional Pacemakers and ICDs • 
https://academic.oup.com/europace/article/22/2/288/5717383 Heart Rhythm Society Consensus Document • 
10.1016/j.hrthm.2017.04.025 External Link 
 III PFA-SHAM trial
 
 PFA-SHAM Trial • 
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079484 SHAM-PVI Trial • 
https://jamanetwork.com/journals/jama/fullarticle/2823283 
 IV Orthopedic Injuries in Cardiology
 
 What Will It Take to Make Fluoroscopy Labs Safer?
 
https://www.medscape.com/viewarticle/what-will-it-take-make-fluoroscopy-labs-safer-2026a1000ox6
 
 Expert Consensus Statement on Enhanced Radiation Protection • 
https://www.jacc.org/doi/10.1016/j.jcin.2026.06.011 'Shed the Lead' and the Injuries. Should Cath Labs Go Lead-Free? • 
https://www.medscape.com/viewarticle/shed-lead-and-injuries-should-cath-labs-go-lead-free-2024a1000hnb Health Hazards of Working in the Interventional Laboratory • 
https://doi.org/10.1016/j.jacc.2014.11.056 
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 The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
 Questions or feedback, please contact news@medscape.net

July 24 2026 This Week in Cardiology

DAPT back in the news, a practice-changing trial in VTE therapy, new knowledge in sudden cardiac death, heart failure definitions updated, and a dumb decision by NICE in the UK are the topics discussed by John Mandrola, MD, in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Antiplatelet Therapy After Stenting
 
 DAPT-MVD Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2517588 HOST-EXAM Trial at 2 years https://pubmed.ncbi.nlm.nih.gov/34010616/ HOST-EXAM Trial at 10 years 10.1016/S0140-6736(26)00422-8 External Link Nick Kurzen on X https://x.com/ncurzen/status/2077676739463922151 
II Aspirin Proves Its Mettle After Hip and Knee Replacement
 
 EPCAT III Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2603649 CRISTAL Trial https://jamanetwork.com/journals/jama/fullarticle/2795528 
III New (and old) Knowledge in Sudden Cardiac Death
 
 Sudden Cardiac Death and its Relation to Cardiac Disease at Autopsy • 
https://doi.org/10.1016/j.jacc.2026.01.029 Sudden Cardiac Death Due to MI With Obstructive and Nonobstructive Coronary Arteries • 
https://doi.org/10.1016/j.jacc.2026.01.030 Frequency of Sudden Cardiac Death and Profiles of Risk • 
https://www.ajconline.org/article/S0002-9149(97)00477-3/fulltext 
IV Heart Failure Diagnosis
 
 AHA/ACC/ESC/WHF Expert Consensus Document • 
http://jacc.org/doi/10.1016/j.jacc.2026.05.036 
V NICE Makes a Dumb Decision
 
 NICE Recommends New Nonsteroidal MRA for Heart Failure 
 https://www.medscape.com/viewarticle/nice-recommends-new-nonsteroidal-mra-heart-failure-2026a1000nzv
 
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Jul 17 2026 This Week in Cardiology Podcast

Listener feedback on ICE vs TEE in AF ablation, fractional flow reserve without a wire or catheter, more bad news for ticagrelor, the POLY-HF trial, and oxygen targets after cardiac arrest are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Listener Feedback
 
Oct 10, 2025 This Week in Cardiology Podcast
 
 https://www.medscape.com/viewarticle/1002990
 
 ICE vs TEE in Atrial Fibrillation Ablation https://jamanetwork.com/journals/jamacardiology/fullarticle/2839370 
II FFR Without the Wire – Angiography-Derived FFR to Guide PCI
 
 ALL-RISE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600949 FAST III Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2601841 FAVOR III Trial 10.1016/S0140-6736(24)02175-5 External Link FAME 2 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1205361
 • 
 Venk Murthy on X https://x.com/venkmurthy/status/2074849421452329456?s=20 
III More Bad News for Ticagrelor
 
Jul 11, 2025 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/1002704
 
 Prasugel, Ticagrelor, or Clopidogrel After PCI https://jamanetwork.com/journals/jamacardiology/fullarticle/2849614 
IV The Polypill in Heart Failure
 
 POLY-HF trial https://www.nature.com/articles/s41591-026-04504-5 
V Oxygen Targets After Cardiac Arrest
 
 LOGICAL Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2513814 ICU-ROX Trial https://link.springer.com/article/10.1007/s00134-020-06196-y Secondary Analysis of the PILOT Trial https://journal.chestnet.org/article/S0012-3692(25)00553-7/fulltext Oxygen Targets in Comatose Survivors of Cardiac Arrest https://www.nejm.org/doi/10.1056/NEJMoa2208686 
You may also like:
 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Jul 10 2026 This Week in Cardiology

Listener feedback on valvular heart disease, statins and frailty, left atrial posterior wall ablation fails again, interpreting medical tests and AI ECG reading are the topics John Mandrola, MD, discusses in this week's podcast.
 
This podcast is intended for healthcare professionals only.
 
To read a partial transcript or to comment, visit:
 
https://www.medscape.com/twic
 
I Listener Feedback
 
 PREVUE-VALVE Study https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5137 
II Statins and Frailty
 
Statin Initiation Tied to Lower Frailty Risk in Older Adults https://www.medscape.com/viewarticle/statin-initiation-tied-lower-frailty-risk-older-adults-2026a1000lec
 
 Statins and Survival Free of Incident Frailty https://doi.org/10.1093/eurheartj/ehag451 
III LA Posterior Wall Isolation Fails Again
 
 CORNERSTONE Trial https://doi.org/10.1093/eurheartj/ehag486 CAPLA Trial https://jamanetwork.com/journals/jama/fullarticle/2800186 
IV Does the Display of Test Results Improve Clinical Decisions?
 
 Interval Likelihood Ratios for Clinical Decsion-Making https://evidence.nejm.org/doi/full/10.1056/EVIDoa2500249 Making Sense of Health Statistics https://journals.sagepub.com/doi/full/10.1111/j.1539-6053.2008.00033.x 
V AI and the ECG and Saving Doctors
 
 Case Report — AI-Enhanced Diagnostics https://www.nature.com/articles/s41591-026-04454-y The New York Times • 
article https://www.nytimes.com/2026/06/22/health/artificial-intelligence-heart-damage.html 
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 
Questions or feedback, please contact news@medscape.net

Jun 26 2026 This Week in Cardiology

The EXCEL debate, the NOBLE trial, alcohol and AF, cardiac devices, and hospital consolidation are the topics covered by John Mandrola, MD, in this week's podcast.

Jan 3, 2020 This Week in Cardiology Podcast

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