Fructose, Knee Sleeves, Weight Loss Variability, and James Krieger

Greg kicks off the episode with an insincere but legally valid apology, followed by some impressive feats of strength. Then, Eric covers a brand new fructose study in a new segment called “Hot Off the Presses,” and Greg shares some new research related to knee sleeves. After that, Eric has a big Research Roundup segment about why some people struggle to lose weight, and Greg provides some tips to help you perfect your turkey roasting. Finally, Greg and Eric interview James Krieger about topics including the insulin hypothesis, non-exercise activity thermogenesis, why you should or shouldn’t get your body composition measured, and more.

TIME STAMPS

0:01:19 Greg’s formal apology

0:05:50 Feats of strength

0:17:52 Hot Off The Press: High fructose diets

• Smajis et al. Metabolic effects of a prolonged, very-high-dose dietary fructose challenge in healthy subjects: https://academic.oup.com/ajcn/advance-article-abstract/doi/10.1093/ajcn/nqz271/5651310?redirectedFrom=fulltext 0:23:17 Hot Off The Press: Greg’s knee sleeve hypothesis. Studies referenced:

https://www.sciencedirect.com/science/article/abs/pii/S002192901930555Xhttps://link.springer.com/article/10.1007/s11332-019-00595-5 0:33:50 Research Roundup: Weight loss success is highly, highly individual

• Ortega-Santos et al: The Key to Successful Weight Loss on a High-Fiber Diet May Be in Gut Microbiome Prevotella Abundance: https://academic.oup.com/jn/article-abstract/149/12/2083/5580874 • Hollstein et al: Metabolic response to fasting predicts weight gain during low-protein overfeeding in lean men: further evidence for spendthrift and thrifty metabolic phenotypes: https://academic.oup.com/ajcn/article/110/3/593/5512175 • Buckland et al: Women with a low-satiety phenotype show impaired appetite control and greater resistance to weight loss: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/women-with-a-lowsatiety-phenotype-show-impaired-appetite-control-and-greater-resistance-to-weight-loss/E47492322273FB7DF00DC688F4882E83 • Yokum and Stice: Weight gain is associated with changes in neural response to palatable food tastes varying in sugar and fat and palatable food images: a repeated-measures fMRI study: https://academic.oup.com/ajcn/advance-article-abstract/doi/10.1093/ajcn/nqz204/5570572?redirectedFrom=fulltext • Klatzkin et al: Negative affect is associated with increased stress-eating for women with high perceived life stress: https://www.sciencedirect.com/science/article/abs/pii/S0031938419304068 1:00:58 The incomplete list of things that affect weight loss variability

1:11:55 To Play Us Out: Turkey roasting tips

1:25:40 Interview with James Krieger

1:28:32 Insulin hypothesis: Definition and shortcomings

1:47:20 Non-exercise activity thermogenesis (NEAT) and weight loss/weight regain

2:10:06 Body composition measurement

• What are the most accurate methods? • How bad is too bad for individual use? • Alberto Nunez DEXA: https://www.youtube.com/watch?v=4X2DFfaTvjI 2:19:25 Research in exercise science/sports nutrition

• Biggest area requiring improvement? • What trends or changes do you hope or expect to see in the near future?

2:42:35 As a coach, do you use any strategies that lack scientific substantiation, or even “go against the grain” of the current consensus in the evidence-based fitness community?

2:46:49 Where can people find James online?

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