This episode of Brain Science features the return of molecular biologist Seth Grant. We briefly review his decades of research into the complexity of the protein structure of the synapse and then we focus on his most recent paper, which describes how the life-span of synapse proteins appears to change as animals age. Grant reflects of the significance of this finding both for animal research and human medicine. Papers discussed in this episode: • Bulovaite, E., Qiu, Z., Kratschke, M., Zgraj, A., Fricker, D. G., Tuck, E. J., Gokhale, R., Koniaris, B., Jami, S. A., Merino-Serrais, P., Husi, E., Mendive-Tapia, L., Vendrell, M., O'Dell, T. J., DeFelipe, J., Komiyama, N. H., Holtmaat, A., Fransén, E., & Grant, S. G. N. (2022). A brain atlas of synapse protein lifetime across the mouse lifespan. Neuron, 110(24), 4057–4073.e8. https://doi.org/10.1016/j.neuron.2022.09.009 • Cizeron, M., Qiu, Z., Koniaris, B., Gokhale, R., Komiyama, N. H., Fransén, E., & Grant, S. G. N. (2020). A brainwide atlas of synapses across the mouse life span. Science (New York, N.Y.), 369(6501), 270–275. https://doi.org/10.1126/science.aba3163 Seth Grant has previously appeared on Brain Science several times including BSP 51, BSP 101, BS 137, BSP 150 and BS 176. Announcements: • Please FOLLOW the Brain Science podcast channel on • YouTube. • The mobile app has been updated and is now called Brain Science Podcast • . The app is free and MyLibsyn Premium subscribers can use it to access transcripts and other premium content. • Dr. Campbell arrived in New Zealand on August 10, 2023. Please reach out if you live in New Zealand or Australia. • Please subscribe or follow Brain Science • in your favorite audio app and please share it with others • . • Get free gift "5 Things You Need to Know about YOUR Brain when you sign up for the free Brain ScienceNewsletter • to get show notes automatically every month. You can also text brainscience to 55444 to sign up. • Support Brain Science • by buying Are You Sure? The Unconscious Origins of Certainty • by Virginia "Ginger" Campbell, MD. (Autographed copies are available) • Learn more ways to support Brain Science • at https://brainsciencepodcast.com/premium

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