375: How AI Is Changing Healthtech Investing, According to Define Ventures’ Lynne Chou O’Keefe

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Lynne Chou O’Keefe is the Founder and Managing Partner of Define Ventures, one of the largest early-stage health tech investment firms, with $800 million in assets under management.

With deep experience across digital health, venture capital, and frontline healthcare systems, Lynne brings a clear-eyed view of why the industry is changing now and where AI can make a meaningful difference.

She is widely recognized for her work backing companies that rethink access, outcomes, and patient experience, and is a trusted voice on how technology, ethics, and human judgment must come together to move healthcare forward.

In this conversation, we discuss:

• Why healthcare still runs on fragmented systems and what that means for where AI can truly move the needle. • How the shift from fee-for-service to value-based care changes incentives and pushes the system toward prevention over volume. • Why patients now expect healthcare to work like transportation or food delivery, and how that expectation reshapes care delivery. • The three phases of AI in healthcare, from administrative efficiency to clinical workflow support and, eventually, clinical decision-making. • Where the ethical boundary sits today between AI-assisted care and AI-led decisions, especially when access to care is limited. • Why the future of healthcare is hybrid by design, with AI augmenting clinicians rather than replacing human judgment.

Resources:

Subscribe to the AI & The Future of Work NewsletterConnect with Lynn on LinkedInAI fun fact articleOn how AI is fixing the biggest problem faced by doctors.