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TWiT

Every week TWiT hosts talk to the smartest people in the world about the most important topics in technology. Join Leo Laporte and other TWiT hosts for these enlightening one-on-one interviews.

Although the show is no longer in regular production, you can enjoy episodes from the TWiT Archives.

Triangulation (Audio)

In a wide-ranging conversation, Leo Laporte talks with Dr. George Church about the history and future of genome sequencing. Dr. Church explains why he is very excited about how they made an organism resistant to all viruses- both known and unknown. 
 

They also talk about: 

 
 • How Dr. Church made sequencing affordable (from $3BN to $600)
 
 • Where are we on sequencing the entire human genome, and why would we even want to?
 
 • How close are we to reversing aging? 
 
 • Should we use gene therapy to double the human lifespan?
 
 • Why genetically engineering cold-resistant elephants could be important for climate change, and what about ultimately bringing back the Mammoth?
 
 • He explains the difference between the hype and reality of CRISPR
 
 • sequencing, synthesis, and delivery
 
 • What are the privacy concerns about companies sharing your genome?
 
 • They discuss the controversy and benefit of reconstructing old viruses like the 1918 flu and even inventing new viruses.
 

Dr. Church is a professor of genetics at Harvard Medical School and a pioneer in personal genetics. He is credited with developing the first methods for sequencing the first genome and also the CRISPR technology. He created several companies, including Nebula Genomics and Veritas Genetics.
 

Host: Leo Laporte
 

Guest: Dr. George Church
 

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Triangulation 433: The Father of Modern Genomics - George Church

New York Times bestselling author Daniel Suarez returns to talk with Leo Laporte about the second book in his 'Delta-v' novel series, 'Critical Mass,' where a group of pioneering astropreneurs must overcome never-before-attempted engineering challenges to rescue colleagues stranded at a distant asteroid—kicking off a new space race in which Earth's climate crisis could well hang in the balance. 
 

Get 'Critical Mass': https://amzn.to/3Yjb9xu
 

Host: Leo Laporte
 

Guest: Daniel Suarez
 

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Triangulation 432: Daniel Suarez: Critical Mass - Daniel Suarez on his latest book 'Critical Mass'

Writer/activist Cory Doctorow and scholar Rebecca Giblin join Leo Laporte to talk about their latest book Chokepoint Capitalism: How Big Tech and Big Content Captured Creative Labor Markets and How We'll Win Them Back. They argue that we're in a new era of "chokepoint capitalism," with exploitative businesses creating insurmountable barriers to competition that enable them to capture value that should rightfully go to others.
 

Get "Chokepoint Capitalism": https://chokepointcapitalism.com
 

Host: Leo Laporte
 

Guests: Cory Doctorow and Rebecca Giblin
 

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Triangulation 431: Cory Doctorow and Rebecca Giblin: Chokepoint Capitalism - How Big Tech and Big Content Captured Creative Labor Markets and How We'll Win Them Back

Tripp Mickle joins Leo Laporte to discuss his new book, "After Steve: How Apple Became a Trillion-Dollar Company and Lost Its Soul". They discuss the shift in Apple's dynamic and approach to products after the passing of Steve Jobs from a company of innovation with Jony Ive, to a company of efficiency under Tim Cook.
 

Host: Leo Laporte
 

Guest: Tripp Mickle
 

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Triangulation 430: Tripp Mickle: After Steve - A Conversation with Tripp Mickle

Amy Webb joins Leo Laporte to discuss her new book, "The Genesis Machine." Webb explains synthetic biology, tells the story of golden rice, and shares a glimpse of the future and the changes we can expect.
 

Get "The Genesis Machine": https://amzn.to/3BC7K2t
 

Host: Leo Laporte
 

Guest: Amy Webb
 

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Triangulation 429: Amy Webb: The Genesis Machine - Looking to the future through the lens of synthetic biology.

Leo Laporte interviews Andy Weir, author of "The Martian," about his new book, "Project Hail Mary." The discussion starts out spoiler-free with a chat about making the book into a film, how Andy Weir approached writing this book, and the time he confused Ryan Reynolds and Ryan Gosling. After a loud and apparent spoiler warning (at 32:04), the two continue their chat by discussing "Project Hail Mary" in depth. Weir shares a bit about the science behind the book, the characters he's created, and other stories he's working on.
 

Project Hail Mary: https://amzn.to/3hLcStp
 
The Martian: https://amzn.to/3v9LUiU
 
Artemis: https://amzn.to/3vahYDf
 

Host: Leo Laporte
 

Guest: Andy Weir
 

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Triangulation 428: Andy Weir's "Project Hail Mary" - A conversation with science-fiction author, Andy Weir

Jason Howell is joined by TWiT's studio engineer to talk about his time as the drummer and founder of the progressive rock band Cairo, creating the Virtual Live Show, and how the intersection of music and tech has evolved.
 

Cairo on YouTube: https://www.youtube.com/JeffBrockmanDirector 
 

Virtual Live Show on Twitter: https://twitter.com/virtualliveshow
 

Host: Jason Howell
 

Guest: Jeff Brockman
 

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Triangulation 427: Jeff Brockman - Prog rock drummer of CAIRO and Virtual Live Show; and Studio Engineer at TWiT.

Flynn Coleman, writer, and international human rights attorney, joins Denise Howell to talk about her book A Human Algorithm: How Artificial Intelligence Is Redefining Who We Are. Flynn argues that we must instill values, ethics, and morals into our robots, algorithms, and other forms of AI by developing and implement laws, policies, and oversight mechanisms to protect us from tech's insidious threats.
 

Get "A Human Algorithm": https://amzn.to/2rIqgH6
 

Host: Denise Howell
 

Guest: Flynn Coleman
 

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Triangulation 426: Flynn Coleman: A Human Algorithm - How Artificial Intelligence Is Redefining Who We Are

Stephen Wolfram is a computer scientist who designed Mathematica, Wolfram Alpha, and the Wolfram Language. He talks to Mikah Sargent about translating between human language, mathematics, and programming languages, how computational language works, and how he has spent his life trying to build computational intelligence up.
 

Host: Mikah Sargent
 

Guest: Stephen Wolfram
 

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Sponsors:

capterra.com/triangulation
LastPass.com/twit

Triangulation 425: Stephen Wolfram: Adventures of a Computational Explorer

Margaret O'Mara, Professor of History at the University of Washington, joins Mikah Sargent to talk about her book The Code: Silicon Valley and the Remaking of America. They dive into the behind-the-scenes history of Silicon Valley, including how the Cold War shaped what Stanford University is today, shine a light on some of the unsung heroes like Ann Hardy and David Morgenthaler, and the legacy of Steve Jobs.
 

Get "The Code": https://amzn.to/32ozIwm
 

Host: Mikah Sargent
 

Guest: Margaret O'Mara
 

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Sponsor:

LastPass.com/twit

Triangulation 424: Margaret O'Mara: The Code - Silicon Valley and the Remaking of America

Mikah Sargent talks with professor Kate O'Neill about her new book, "Waste" and what we can do about the ever-growing amount of trash each of us produces. They discuss what happens to much of our e-waste and how tech companies could work proactively, including the right-to-repair. One big issue is how China changed recycling world-wide, complicating the recycling industry and what happens next. Some solutions to this problem include finding alternatives to plastic and developing a global solution to our waste problem. Mikah and Kate also coin the term "Garbology."
 

Buy "Waste": https://amzn.to/2luYrPt
 

Host: Mikah Sargent
 

Guest: Kate O'Neill ("Waste" author)
 

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Sponsor:

LastPass.com/twit

Triangulation 417: Kate O'Neill: Waste - How trash is shaping global economies and politics

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