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Lyt når som helst, hvor som helst 

Dr. Mark Hyman

Welcome to The Dr. Hyman Show, the podcast helping you take ownership of your health and reimagine what’s possible. Hosted by Dr. Mark Hyman—physician, bestselling author, and pioneer in functional medicine—this show explores the most pressing issues of our time: chronic disease, nutrition, mental health, food policy, prevention, and longevity.

In a world where our food system fuels disease and conventional healthcare often overlooks root causes, Dr. Hyman delivers evidence-based insights and expert conversations that empower you to become the CEO of your own health.

The Dr. Hyman Show goes beyond the headlines to envision a future where our food and healthcare systems support vitality, reduce chronic disease, and protect the environment. Whether you’re looking for actionable protocols, deeper understanding, or meaningful conversations at the intersection of health, food, and policy, this podcast is your trusted guide.

Tune in, take the lead, and transform your health one episode at a time.

The Doctor's Farmacy with Mark Hyman, M.D.

High cholesterol is one of the most common reasons people are told they’re at risk for heart disease. But what if cholesterol isn’t the root problem? What if it’s actually a signal of deeper metabolic dysfunction—and focusing on the number alone causes us to miss what’s really driving cardiovascular risk?

In today’s episode, we explore a functional medicine approach to cholesterol and heart health, including:

 Why high cholesterol is often a downstream effect of insulin resistance, inflammation, and metabolic dysfunction

 The surprising role sugar, refined carbohydrates, and ultra-processed foods play in driving unhealthy cholesterol patterns

 How healthy fats, protein, fiber, and gut health influence cholesterol regulation and cardiovascular risk

 The nutrition and lifestyle changes that can improve metabolic health—and begin shifting key biomarkers in as little as 10 days

When it comes to cholesterol, the better question isn’t always, "How do I lower this number?" It’s, "Why is it elevated in the first place?" By addressing the root causes—from blood sugar imbalance and inflammation to diet, movement, sleep, and stress—you can improve not just your cholesterol, but the underlying metabolic health that drives long-term cardiovascular risk.

Resources Mentioned:

 Learn more about the 10-Day Detox: https://bit.ly/3PIUoxf

 Listen to my full conversation with Dr. Aseem Malhotra: https://bit.ly/4x5wEUR

 Track your metabolic and cardiovascular health biomarkers: functionhealth.com/mark for 160+ lab tests at just $365/year. Use code MARK2026 for $50 off.

Have a question you'd love answered on Office Hours? Submit it here

(0:25) Introduction 

(1:11) Understanding and Addressing Cholesterol with Functional Medicine 

(2:20) Metabolic Dysfunction, Health Reset, and Dietary Recommendations 

(8:07) Example Daily Meal Plan and Importance of Movement 

(12:46) Sleep, Stress, and Supplements for Cholesterol 

(14:27) Cardiovascular Risk Insights and Dr. Asim Malhotra Clip 

(20:30) Closing Remarks, Listener Engagement, and Social Media 

(21:57) Disclaimer, Medical Guidance, and Gratitude to Sponsors

Why Your Cholesterol Is High—and How to Start Fixing It in 10 Days

Depression is often treated as a single condition. But two people with the same diagnosis can have completely different underlying causes.

On this episode of The Dr. Hyman Show, I’m rejoined by Dr. James Greenblatt to explore why depression may be less of a disease and more of a signal that something deeper is going on. We discuss how a root-cause approach can uncover what’s driving symptoms and why finding what’s beneath them matters.

Watch the full conversation on YouTube or listen wherever you get your podcasts.

We discuss:

 
Could nutrient deficiencies, inflammation, or gut issues be contributing to symptoms of depression

 
What tests can help uncover the biological factors that may be affecting mood and mental health

 
Why can two people with depression have different root causes—and require different solutions

 
How do blood sugar imbalances, hormone changes, and metabolic health influence the brain

 
What should you know about antidepressants, tapering, and addressing the factors that may affect recovery

Hope doesn't come from ignoring symptoms—it comes from understanding them. Sometimes the most important question isn't "What's wrong with me?" but "What might my body be trying to tell me?"

One of the key themes in this conversation is that mental health is deeply connected to what's happening throughout the body. In my Brainshaping Academy, you'll learn how to support the biological systems that shape cognitive, emotional, and mental well-being.

View Show Notes From This Episode

Depression symptoms aren’t always just “in your head.” Dr. Hyman’s Brainshaping Academy shows how your gut, immune system, and nutrient levels may be responsible—and what you can do about it. → https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link

Get Free Weekly Health Tips from Dr. Hyman

https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Sign Up for Dr. Hyman’s Weekly Longevity Journal

https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Join the 10-Day Detox to Reset Your Health

https://drhyman.com/pages/10-day-detox

Join the Hyman Hive for Expert Support and Real Results

https://drhyman.com/pages/hyman-hive

This episode is brought to you by Seed, Made In Cookware, Perfect Amino, BON CHARGE, and Big Bold Health.Go to seed.com/hyman and use code 20HYMAN to get 20% off your first month.Visit madeincookware.com and use code HYMAN10 for 10% off your order.Go to bodyhealth.com and use code HYMAN20 to get 20% off your first order.Head to boncharge.com/hyman and use code HYMAN for 15% off.Go to bigboldhealth.com/drhyman and use code HYMAN15 to save 15% on your first order.

(0:00) Antidepressants, Cooking at Home, and Introducing the Brain Shaping Academy 

(3:14) Prevalence of Depression and Personal Stories 

(4:27) Exploring Root Causes of Depression 

(5:07) Influential Figures and Orthomolecular Psychiatry 

(12:29) Gut Health, Gluten Sensitivity, and Brain Inflammation 

(20:22) Neuroinflammation and Root Causes of Depression 

(22:10) Biomarkers, Hormonal Imbalances, and Insulin Resistance 

(25:34) The Role of Toxins and Diagnostic Testing 

(31:15) Case Studies and Patient Stories 

(34:29) Challenges in the Mental Health System 

(37:05) Effectiveness of Antidepressants and Patient Resistance 

(43:17) Role and Need for Nutritional Lithium 

(45:00) Sponsor: Big Bold Health 

(46:00) Identifying Nutritional Lithium Need 

(47:13) Integrating Modalities and Supplements vs. Medications 

(48:04) Psychotherapy Methods and Addressing Root Causes 

(49:34) Dr. Greenblatt's Book and the Finding a Living Platform 

(51:03) Systematic Approach and Global Impact of Depression 

(52:39) Sharing, Disclaimer, and Closing Remarks

Antidepressants Explained: Benefits, Risks, and Alternatives for Depression | Dr. James Greenblatt

Morning routines have become one of the most talked-about topics in health and wellness—but it’s not just about productivity or checking boxes. How you start your morning has a direct biological impact on your brain, your energy, your metabolism, and even how well you sleep at night. Yet, so many people inadvertently sabotage their biology first thing in the morning with dopamine hits, sugar, and stress.

In today’s episode, I’m pulling back the curtain on my morning routine to share the science-backed, foundational habits I use every day, including:

 What morning sunlight, hydration, and movement actually do to reset your internal clock and regulate your hormones

 A step-by-step breakdown of my personal daily flow, including electrolyte rehydration, full-spectrum light glasses, qigong, and meditation

 The exact longevity ingredients I put into my morning "medicine shake"

 How to maintain consistency on the road with non-negotiable travel habits

A powerful morning routine isn’t about creating a perfect, complicated schedule—it's about doing the right things consistently. The key is starting simple with just one or two small habits that compound over time, giving you the grounded foundation you need to show up as the CEO of your own health.

Visit ⁠functionhealth.com/mark for 160+ lab tests at just $365 a year. Use code mark 2026 for $50 off.

Want to learn how healing your body can help heal your mind? Sign up for the Brain Shaping Academy HERE.

Have a question you’d love answered on Office Hours? Submit it here

The Perfect Morning Routine for a Longer, Sharper Life | Dr. Mark Hyman

For far too long, many women have been told their symptoms were normal, exaggerated, or simply something they had to live with—treated as isolated problems instead of part of a much larger hormonal transition happening inside the body.

On this episode of The Dr. Hyman Show, I’m joined by Dr. Sharon Malone, host of The Second Opinion podcast and Chief Medical Advisor at Alloy Women’s Health.

We discuss how menopause and hormone therapy became so misunderstood, the real story behind the Women’s Health Initiative study, and why a more individualized, prevention-focused approach to women’s health is long overdue.

Watch the full conversation on YouTube, or listen wherever you get your podcasts.

We explore:

 
Why so many women enter perimenopause completely unprepared—and how symptoms can begin years before menopause officially starts

 
What the Women’s Health Initiative actually found, and how one medical narrative reshaped women’s healthcare for decades

 
How menopause affects far more than reproduction, including the brain, heart, sleep, metabolism, and bone health

 
What you should know about hormone therapy today, including timing, individualized treatment, and understanding risk in context

 
The daily habits that still matter most for healthy aging, whether or not you choose hormone therapy

Midlife health should never be reduced to “just deal with it.” The more women understand what’s happening inside their bodies, the earlier they can take steps to protect their long-term health and quality of life.

View Show Notes From This Episode

Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health - ⁠Click Here⁠

Get Free Weekly Health Tips from Dr. Hyman

https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Sign Up for Dr. Hyman’s Weekly Longevity Journal

https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Join the 10-Day Detox to Reset Your Health

https://drhyman.com/pages/10-day-detox

Join the Hyman Hive for Expert Support and Real Results

https://drhyman.com/pages/hyman-hive

This episode is brought to you by Paleovalley, Pique, Perfect Amino, Rho, Sunlighten and BIOptimizers.

Head to paleovalley.com/hyman to save 15% off your first order today.

Secure 20% off your order plus a free starter kit at piquelife.com/hyman.

Go to bodyhealth.com and use code HYMAN20 to get 20% off your first order.

Head over to rhonutrition.com and use code HYMAN to get 20% off their entire product line.

Visit sunlighten.com and use code HYMAN to save up to $1600 today!

Head to bioptimizers.com/hyman and use promo code HYMAN at checkout to save 15%.

(0:00) Introduction, survey on hormone use, and Dr. Sharon Malone’s expertise 

(4:04) Importance of women's health research and historical neglect 

(5:35) Lack of education and preparation for menopause 

(6:28) Societal and historical biases in women's health 

(9:05) Observational studies vs. randomized controlled trials 

(13:30) Life cycles, hormonal changes, and stages in women 

(19:26) Detailed stages of hormonal changes and perimenopause 

(23:00) Misdiagnosis and definition of menopause 

(25:02) The term "postmenopausal" and its significance 

(26:34) Impact of menopause on organ systems and major symptoms 

(31:19) Lifestyle factors and hormone therapy options 

(39:25) Black box warning, Women’s Health Initiative, and therapy timing 

(45:00) Women's Health Initiative findings and breast cancer risk 

(47:57) Reinterpreting breast cancer risk and black box warning 

(53:21) Personalized hormone therapy and clinical diagnosis 

(59:55) Importance of estrogen and bioidentical vs. synthetic hormones 

(1:03:35) Addressing sexual health and testosterone use for women 

(1:08:05) FDA-approved peptides for women’s arousal disorder 

(1:09:57) Long-term benefits of hormone therapy 

(1:12:43) Early menopause, hormone therapy, and health impacts 

(1:15:07) Estrogen’s role in brain health and dementia prevention 

(1:16:22) Alzheimer’s risk in women and hormonal

Millions of Women Stopped Taking Hormones Because of a Misread Study | Dr. Sharon Malone

Hormone replacement therapy is one of the most talked about—and misunderstood—topics in women’s health. For years, women were told HRT was dangerous. Now, the conversation is shifting, but many are still left confused about what’s actually safe, when to start, and whether hormones are even right for them.

In today’s episode, I’m joined by Dr. Cindy Geyer from my clinic, The UltraWellness Center, to answer the most common questions we received from our audience about hormone replacement therapy, including:

 What the latest research actually says about the safety of HRT—including breast cancer and cardiovascular risk

 Why timing matters and the critical “window of opportunity” around perimenopause and menopause

 The difference between bioidentical hormones, synthetic hormones, compounded options, and patches vs. oral therapy

 How hormones impact sleep, brain fog, weight distribution, insulin resistance, libido, bone health, and healthy aging

 Natural strategies that can support hormone balance alongside—or without—HRT, including nutrition, exercise, stress reduction, and targeted supplements

 How functional medicine personalizes hormone therapy through testing, estrogen metabolism, gut health, genetics, and lifestyle factors

Menopause is not just a hormone issue—it’s a full-body metabolic transition. And hormone therapy isn’t one-size-fits-all. The key is understanding your biology, your symptoms, and your long-term health goals so you can make informed decisions that support vitality, resilience, and healthy aging.

Visit ⁠functionhealth.com for 160+ lab tests at just $365 a year.

Want more on brain health? Sign up for the Brain Shaping Academy HERE.

Have a question you’d love answered on Office Hours? Submit it here

As a special thank you for our listeners, we’re offering $300 off a Functional Medicine Consultation Package, the most comprehensive service offering at Dr. Hyman's Functional Medicine Clinic, The UltraWellness Center. To learn more and book your consultation, please schedule a New Patient Discovery Call at the link HERE and reference the Dr. Hyman Show.

Disclaimer: Offer expires July 31, 2026. Functional Medicine Consultation Appointments must be booked by July 31,2026 but may take place at a later date. The initial call with a New Patient Engagement Coordinator is required to book the appointment. Offer not valid on other appointment types or existing appointments. Offer valid for bookings with Dr. Boham, Dr. Geyer, Dr. LePine and Dr. Papanicolaou.

(0:00) Welcome, introduction, and overview of hormone replacement therapy 

(1:26) Introduction of Dr. Cindy Geyer and safety of HRT 

(4:13) Timing, risks, and cancer concerns with HRT 

(7:06) Functional medicine perspective and factors in starting HRT 

(12:10) Benefits, timing, and natural alternatives to HRT 

(16:33) Prescription, bioidentical, and compounded hormones 

(19:20) Symptoms improved by HRT and libido considerations 

(22:24) Vaginal estrogen, progesterone, and recognizing need for therapy 

(24:25) Health markers and types of hormone testing 

(27:08) Duration, contraindications, and tailored hormone therapy 

(33:34) Preview: Dr. Sharon Malone on breast cancer risk 

(42:24) Introduction and details of Brain Shaping Academy

Is HRT Safe? 10 Questions Women Ask Most — Answered by a Functional MD

We’re surrounded by plastics and environmental chemicals every day, but only recently have scientists begun to understand how deeply they may be affecting human health.

On this episode of The Dr. Hyman Show, I sit down with Dr. Shanna Swan to explore what the latest science reveals about plastics, fertility, hormone health, and the everyday habits that may be shaping our biology more than we realize.

Watch the full conversation on YouTube, or listen wherever you get your podcasts.

We Examine:

• Why scientists are increasingly concerned about declining sperm counts, fertility, and hormone health

• What microplastics, phthalates, BPA, and PFAS actually do inside your body

• Why heating food in plastic can dramatically increase exposure to endocrine-disrupting chemicals

• The practical changes that may help you reduce exposure and support long-term health

This conversation isn’t about fear, rather it’s about understanding how everyday exposures shape our health and where small, practical changes can make a meaningful difference.

If this episode has left you thinking differently about everyday exposure and you want to learn more, here are a few great places to start:

• Watch The Plastic Detox 
• Explore Dr. Swan’s work through the Action Science Initiative
• Visit UnplasticYourLife.com for practical ways to reduce exposure at home

View Show Notes From This Episode

Get Free Weekly Health Tips from Dr. Hyman

https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Sign Up for Dr. Hyman’s Weekly Longevity Journal

https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Join the 10-Day Detox to Reset Your Health

https://drhyman.com/pages/10-day-detox

Join the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hive

This episode is brought to you by Seed, Big Bold Health, Timeline, BON CHARGE, Sulighten and BIOptimizers.

Go to seed.com/hyman and use code 20HYMAN to get 20% off your first month.

Go to bigboldhealth.com/drhyman and use code HYMAN15 to save 15% on your first order.

Visit timeline.com/drhyman for 20% off a subscription on top of new starting price of $79.

Head to bioptimizers.com/hyman and use promo code HYMAN at checkout to save 15%.

Head to fatty15.com/HYMAN today and use code HYMAN for 15% off your 90-day subscription Starter Kit.

(0:00) Microplastics in the human body and their sources 

(0:56) Introduction to Dr. Shanna Swan 

(3:34) The Plastic Detox documentary and endocrine disruptors 

(5:21) Dr. Swan's research journey and phthalates 

(6:29) Decline in sperm count and reproductive impacts 

(8:45) Early research and phthalate syndrome in humans 

(11:03) Sources and broader impact of endocrine-disrupting chemicals 

(19:38) Classes of hormone-altering chemicals and health impacts 

(22:51) Health impacts beyond reproduction 

(24:20) Personal and clinical experiences with microplastics 

(27:02) Measuring microplastics and routes of human exposure 

(29:29) Methods to reduce microplastic exposure 

(31:14) Biological and regulatory aspects of microplastics 

(35:02) Plastic Detox movie findings and intervention results 

(41:16) Chemicals in microplastics and their effects 

(47:21) Legislation and consumer protection against toxic chemicals 

(50:54) Diagnostic testing for toxic exposure: importance and costs 

(53:09) Practical steps to reduce chemical exposures 

(55:35) Avoiding plastic and toxic exposures in daily life 

(58:10) Skincare, fragrance, and chemical exposure 

(1:01:19) Rapid-fire questions on health and environmental practices 

(1:09:06) Resources for testing and exposure reduction

The Latest Science on Microplastics — And What They’re Doing to Your Body | Dr. Shanna Swan

Hydration affects far more than thirst. Even mild dehydration can impact your focus, memory, mood, energy, and overall brain performance—yet most people walk through the day without realizing they’re under-hydrated. The problem isn’t just not drinking enough water. It’s also caffeine overload, low electrolytes, processed foods, and inconsistent habits that quietly leave your brain and body struggling to keep up.

In today’s episode, we break down how hydration impacts brain health and what you can do to optimize it, including:
• Why even a 1–2% drop in hydration can lead to brain fog, fatigue, headaches, and reduced concentration
• The hidden role electrolytes play in energy, focus, and actually absorbing the water you drink
• How caffeine can quietly contribute to dehydration and create a cycle of fatigue and dependency
• Simple strategies to improve hydration—from morning water habits to eating more water-rich whole foods

Hydration isn’t just about drinking more water—it’s about helping your body and brain function the way they’re designed to. Small, consistent shifts can dramatically improve your energy, clarity, focus, and overall resilience.

Visit ⁠functionhealth.com for 160+ lab tests at just $365 a year.

Want more on brain health? Sign up for the Brain Shaping Academy HERE.

Have a question you’d love answered on Office Hours? Submit it here

Are You Secretly Dehydrated? Why a 1% Drop Kills Your Focus and Mood

Most health and fitness advice for women is based on research done in men. That’s something we need to rethink.

On this episode of The Dr. Hyman Show, I sit down with Dr. Stacy Sims, an exercise physiologist and leading researcher in women’s health. Her work has focused on how female physiology actually changes over time—and how training and nutrition need to change with it.

Watch the full conversation on YouTube, or listen wherever you get your podcasts.

We explore:

• Why eating less and doing more cardio can make fat loss harder

• What actually changes in your metabolism in your 30s and 40s

• How to train for strength—and why it matters for long-term health

• Why most workouts aren’t building muscle (and what to do instead)

• How to eat and time protein to support recovery, energy, and better sleep

A lot of the advice women have been given doesn’t account for how the body actually changes. Adjusting how you train and eat can make a meaningful difference in your energy, strength, and long-term health.

If you’re interested in learning more, Dr. Stacy Sims is offering my listeners 15% off her online courses with the code DRSTACYSIMS15OFF.

View Show Notes From This Episode

Get Free Weekly Health Tips from Dr. Hyman

https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Sign Up for Dr. Hyman’s Weekly Longevity Journal

https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Join the 10-Day Detox to Reset Your Health

https://drhyman.com/pages/10-day-detox

Join the Hyman Hive for Expert Support and Real Results

https://drhyman.com/pages/hyman-hive

This episode is brought to you by Rho, Pique, Perfect Amino, Sunlighten, Korrus and Made In Cookware.

Head over to rhonutrition.com and use code HYMAN to get 20% off their entire product line.

Secure 20% off your order plus a free starter kit at piquelife.com/hyman.

Go to bodyhealth.com and use code HYMAN20 to get 20% off your first order.

Visit sunlighten.com and use code HYMAN to save up to $1600 today!

Visit korrus.com/drhyman for 15% off their newest product OIO Sphere with code HYMANSPHERE15.

Visit madeincookware.com and use code HYMAN10 for 10% off your order

(0:00) Women’s unique health needs, fitness, and nutrition mistakes 

(0:56) Introduction of Dr. Stacy Sims 

(3:34) Women’s health and fitness through life stages 

(5:39) Navigating diet, exercise, and cognitive health for women 

(24:00) Benefits and misconceptions of heavy weight lifting for women 

(30:55) Understanding anovulatory cycles and high intensity interval training (HIIT) 

(35:47) Reducing inflammation and proper high intensity exercise 

(39:11) How to properly perform HIIT 

(46:06) Overcoming gym intimidation and starting strength training 

(50:12) Importance of community, support, and lifestyle on longevity 

(55:01) Optimizing nutrition: circadian rhythm, time-restricted eating, and protein 

(1:02:44) Post-exercise nutrition and fasted vs fed workouts 

(1:08:01) Common nutrition mistakes for women 

(1:12:17) Scheduling self-care and wellness meetings 

(1:13:43) Quick fire questions on women’s health and fitness 

(1:17:40) Benefits of creatine and favorite workout snacks 

(1:18:23) Morning vs evening workouts and advice for younger self 

(1:19:28) Where to learn more about Dr. Stacy Sims and Collective X Health 

(1:20:20) Closing remarks, sharing, and social media 

(1:21:15) Disclaimer, importance of healthcare practitioners, and sponsor gratitude

Women Are Not Small Men! Why Fitness Advice Is Failing Half the Population | Dr. Stacy Sims

Autoimmune disease is often treated as something random, lifelong, and out of your control. But what if it’s not your body malfunctioning—what if it’s your immune system responding exactly the way it’s designed to, to something it sees as a threat? When you understand what’s driving that response, everything changes.

Here’s what I cover in today’s episode:
• The 5 key drivers—food, toxins, gut health, infections, and stress—and how they disrupt the immune system
• Why diet is one of the most powerful levers for turning inflammation on or off every single day
• The connection between leaky gut, the microbiome, and immune dysfunction
• A practical, functional medicine framework to start reducing symptoms and addressing the condition at the root

Autoimmune disease isn’t random—it’s the result of cumulative inputs over time. When you begin to change those inputs, you can shift your biology, calm the immune system, and change the trajectory of your health.

Visit ⁠functionhealth.com for 160+ lab tests at just $365 a year.

Join the 10-Day Detox: https://drhyman.com/pages/10-day-detox

Have a question you’d love answered on Office Hours? Submit it here 

The waitlist is open** 

Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health - Click here

(0:12) Introduction, Sponsor: Function Health, and Overview of Autoimmune Diseases 

(1:38) Immune System, Causes, and Triggers of Autoimmune Disease 

(3:45) Common Mistakes and Root Causes in Treating Autoimmune Disease 

(5:26) Food, Diet, and Anti-Inflammatory Strategies 

(11:47) Toxins, Gut Health, and the Microbiome 

(17:32) Hidden Infections and Treating by Root Cause 

(19:38) Stress and Other Triggers for Autoimmune Disease 

(23:14) Sponsor: Brain Shaping Academy 

(24:10) Audience Engagement, Sharing, and Subscription 

(25:19) Disclaimer, Professional Advice, and Sponsor Gratitude

The 5 Root Causes of Autoimmune Disease (And How to Start Healing)

We tend to think of heart disease, cancer, and Alzheimer’s as separate problems. But what if they all stem from the same underlying process?

On this episode of The Dr. Hyman Show, I sit down with Dr. Eric Verdin, whose research, including work on compounds like urolithin A, is helping reshape how we think about aging and long-term health. We explore why aging may be the biggest driver of chronic disease and what that means for how you approach your health.

Watch the full conversation on YouTube, or listen wherever you get your podcasts.

We unpack:

• How your immune system becomes both overactive and less effective over time

• What chronic inflammation is doing inside your body and how to start bringing it back into balance

• Why cellular energy and mitochondrial health are key to repair and recovery

• How your microbiome shapes inflammation, immunity, and long-term health

• The daily habits that impact longevity most and where people get it wrong

This conversation reflects a shift in how we think about health, moving beyond treating disease to understanding what’s driving it in the first place.

View Show Notes From This Episode

Get Free Weekly Health Tips from Dr. Hyman

https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Sign Up for Dr. Hyman’s Weekly Longevity Journal

https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast

Join the 10-Day Detox to Reset Your Health

https://drhyman.com/pages/10-day-detox

Join the Hyman Hive for Expert Support and Real Results

https://drhyman.com/pages/hyman-hive

This episode is brought to you by Timeline, Seed, BIOptimizers, BON CHARGE, Paleovalley and Big Bold Health.

Visit timeline.com/drhyman for 20% off a subscription on top of the new starting price of $79.

Go to seed.com/hyman and use code 20HYMAN to get 20% off your first month.

Head to bioptimizers.com/hyman and use promo code HYMAN at checkout to save 15%.

Head to boncharge.com/hyman and use code HYMAN for 15% off.

Head to paleovalley.com/hyman to save 15% off your first order today.

Go to bigboldhealth.com/drhyman and use code HYMAN15 to save 15% on your first order.

(0:00) Biological age vs. cholesterol in heart disease and chronic disease risk 

(0:50) Introduction of Dr. Eric Verdin and his work 

(1:23) Sponsor: Brain Shaping Academy 

(1:51) Sponsor: Mitopure 

(2:54) Sponsor: Seed 

(3:48) Welcoming Dr. Eric Verdin and longevity framing 

(5:42) The geoscience hypothesis and modifying age as a risk factor 

(8:21) Early-stage interventions in aging and potential for life extension 

(9:56) Longevity skepticism and practical steps for today 

(11:20) Mitochondria, inflammation, and hallmarks of aging 

(17:20) Mitochondrial DNA, inflammation, and immune system aging 

(22:17) Innate vs. adaptive immunity and immune aging 

(28:47) Strategies to combat immune aging 

(33:07) Gut health, inflammation, and foundational elements of longevity medicine 

(38:20) Social connections, sociogenomics, and cellular energy in aging 

(46:29) Cellular repair systems and postbiotics 

(50:33) Sponsor: Paleo Valley 

(52:34) Sponsor: Big Bold Health 

(53:23) Urolithin A, immune rejuvenation, and longevity interventions 

(59:08) Longevity and functional medicine approaches 

(1:02:27) Big data, AI, and the evolution of medicine 

(1:04:26) Microbiome, diet, and gut health 

(1:06:14) Measuring biological age and biological clocks 

(1:09:37) Future of health monitoring and closing remarks

The Perfect Morning Routine for a Longer, Sharper Life | Dr. Mark Hyman

Lyt når som helst, hvor som helst

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