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Dr. Mark Hyman

Welcome to The Dr. Hyman Show, the groundbreaking podcast redefining health in America and empowering you to take ownership of your health. Hosted by Dr. Mark Hyman—this show tackles the most pressing issues of our time: chronic disease, mental health, food policy and controversy, prevention and recovery, and longevity. In an era where our food system fuels disease and outdated healthcare models fail to address root causes, Dr. Hyman delivers evidence-based insights and expert interviews to help you become the CEO of your own health—something your doctor isn’t doing.
The Dr. Hyman Show goes beyond the headlines to reimagine a food and healthcare system that protects health, unburdens our economy from the weight of chronic disease, supports the environment, and secures a vibrant future for all Americans. Whether you’re looking for cutting-edge protocols to transform your health, strategies to combat the chronic disease epidemic, or deep conversations about how wellness intersects with food, politics, and the environment, this podcast is your trusted guide. Rethink disease, claim your health, and join the movement for a healthier nation—tune into The Dr. Hyman Show today!

The Doctor's Farmacy with Mark Hyman, M.D.

Longevity isn’t just about what you eat or how you train—it’s really more about whether you believe your body is worth investing in.

On this episode of The Dr. Hyman Show, I’m joined by my longtime friend and colleague Dr. Gabrielle Lyon to explore why muscle may be one of the most overlooked drivers of long-term health. We focus on practical, accessible ways to build strength as you age, and why muscle plays a much bigger role in your health than most people realize.

We explore:

• How strength training supports your blood sugar and metabolic health, beyond what the scale can show

• Why muscle quality—not weight—is a stronger predictor of long-term health

• How building strength helps you stay mobile, capable, and resilient as you age

• What most people miss about protein and muscle health

Aging well is something you can actively support, starting with how you care for your body today. And strength is one of the most powerful places you can begin.

View Show Notes From This Episode

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This episode is brought to you by Timeline, PerfectAmino, BIOptimizers, Mau Nui, Made In Cookware and BON CHARGE.

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(0:00) Introduction and Dr. Gabrielle Lyon's background

(1:00) Protein's importance across ages and muscle benefits

(3:28) Muscle: A neglected organ and its metabolic roles

(8:01) Assessing muscle quality and functional health

(13:09) Resistance training and muscle rejuvenation strategies

(19:33) Muscle's immune and hormonal functions

(22:29) Myokines and body composition analysis

(26:17) Strength training and innovative techniques

(32:05) Muscle as the organ of longevity and protein's significance

(38:12) Dietary guidelines and protein requirement debates

(48:08) Amino acids, protein turnover, and intake strategies

(59:48) Metabolic flexibility and creatine's benefits

(1:00:21) Sponsor: Timeline's research on urolithin A

(1:02:20) Mitochondrial health and muscle-centric medicine

(1:08:14) Muscle health's mismatch with chronic diseases

(1:10:20) Dr. Lyon's longevity practices and quickfire questions

(1:16:03) Strength's importance during menopause and cold exposure

(1:18:51) Dr. Lyon's career highlights and resources

(1:20:17) Closing remarks and disclaimers

Muscle Is the Key to Longevity (Not Fat Loss) | Dr. Gabrielle Lyon

What Should I Actually Eat?
Diet confusion is everywhere. But the truth is, there’s no one-size-fits-all diet. The best diet is the one that works for your biology. In this Office Hours episode, I answer your most common diet questions and break down the core principles everyone should understand before choosing how to eat. 

In this episode I break down:
• Why the “best diet” is personalized—and why ideology should never override biology
• The universal principles everyone should follow, regardless of diet
• Why ultra-processed foods—not carbs, fat, or protein—are the real problem
• How blood sugar dysregulation drives chronic disease, including mental health issues
• Keto, paleo, vegan, and Mediterranean: who they help, common mistakes, and what to watch for
• How to tell if your diet is working—using symptoms, energy, digestion, mood, and labs

Your body is the smartest doctor in the room. The key is learning how to listen. 

Visit ⁠functionhealth.com⁠ for 160+ lab tests at just $365 a year.

Helpful Resources:
Join the 10-Day Detox to Reset Your Health
https://drhyman.com/pages/10-day-detox

Have a question you’d love answered on Office Hours? Submit it here 👉 https://docs.google.com/forms/d/e/1FAIpQLSdNF2y4lFWEOMLlzVNlFDpJ4xl7oOpH9NlImMoHr5mHggL_Ww/viewform?usp=header

Office Hours: How to Choose the Best Diet for Your Body

On this episode of The Dr. Hyman Show, I’m rejoined by psychiatrist and Harvard professor Dr. Chris Palmer for a conversation that challenges how we’ve been taught to think about mental illness.

For decades, psychiatry has focused on managing symptoms—often without asking what’s actually driving them. We discuss a different way of understanding mental health, one that looks beyond diagnostic labels and considers how whole-body biology influences brain function, resilience, and recovery. 

Watch the full conversation on YouTube or listen wherever you get your podcasts.

In this conversation, we explore:

• Why mental illness is rising alongside obesity, diabetes, and other chronic diseases

• How whole-body biology influences mood, focus, and emotional resilience

• The link between inflammation, metabolic dysfunction, and conditions like depression and bipolar disorder

• How nutrition, testing, and lifestyle changes can support real recovery

If mental health has ever felt close to home for you or someone you care about, this conversation is meant to offer clarity, compassion, and a place to start.

This episode was recorded live at the Eudēmonia Summit, a conference exploring the future of health, longevity, and well-being. Learn more at eudemonia.net.

View Show Notes From This Episode

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Join the Hyman Hive for Expert Support and Real Results

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This episode is brought to you by Timeline, BON CHARGE, Qualia, Paleovalley, Pique and Korrus.

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(0:00) Introduction to mental health crisis and guest Dr. Christopher Palmer

(1:31) Eudaimonia Summit and psychiatric revolution

(3:06) Traditional and systemic views on psychiatric disorders

(7:23) Misconceptions and stigma surrounding mental disorders

(10:15) The impact of childhood experiences on mental health

(13:28) Root causes of mental illness: Inflammation and brain dysfunction

(21:23) Metabolic dysfunction in mental illness

(24:15) Significance of metabolism in mental health

(27:47) Metabolic nutritional psychiatry and premature mortality

(32:34) The mental health revolution and metabolic treatments

(34:16) Ketogenic diet as a potential treatment for mental disorders

(37:18) Functional and network medicine in mental health

(41:13) Biomarkers and potential treatments in metabolic mental health

(49:07) Ketogenic therapy and its anti-inflammatory effects

(50:12) Historical and emerging paradigms in psychiatry

(54:38) Integrating functional medicine into mainstream psychiatry

(56:20) Addressing chronic disease in national health discussions

(58:22) Closing remarks and further resources

(59:02) Podcast outro and call to action

Why Mental Illness Is a Metabolic Problem—and What That Means for Your Health | Dr. Chris Palmer

Most of us don’t realize how much alcohol affects our bodies until we take a break. In this first episode of Office Hours, I break down what really happens when you give up alcohol for 30 days. Alcohol impacts nearly every system—from your brain and hormones to your gut, liver, and immune system—but the good news is your body begins repairing itself far faster than most people expect.

I discuss:

• What alcohol really is—and why the “buzz” is actually your brain slowing down

• How alcohol affects neurotransmitters like GABA, dopamine, and glutamate

• Why even moderate drinking disrupts sleep, mood, hormones, and metabolism

• How alcohol impacts the liver, gut microbiome, immune system, and cancer risk

• Why hangovers feel like the flu—and what’s actually happening in your body

• What happens when you stop drinking, week by week, from detox to deep repair

• The surprising benefits to energy, focus, skin, sleep, and emotional resilience

• Practical tools to manage cravings, social pressure, and sleep disruption

• Why community support makes behavior change easier and more sustainable

Your body has an incredible ability to heal and often, it just needs you to take your foot off the gas. Try it for 30 days. You may be amazed by how different you feel.

If you want extra support, join us for the Hive January Challenge, where we’ll guide you through the process, track progress, and share experiences together.

Visit functionhealth.com for 160+ lab tests at just $365 a year.

Helpful Resources:

Join the 10-Day Detox to Reset Your Health 

https://drhyman.com/pages/10-day-detox

Join the Hyman Hive for Expert Support and Real Results 

https://drhyman.com/pages/hyman-hive

Have a question you’d love answered on the podcast? Submit it here 👉 https://docs.google.com/forms/d/e/1FAIpQLSdNF2y4lFWEOMLlzVNlFDpJ4xl7oOpH9NlImMoHr5mHggL_Ww/viewform?usp=header

(0:12) Introduction and the power of personal health agency

(0:51) Joining the Hyman Hive community and dry January benefits

(2:07) Understanding the broad effects of alcohol on health

(7:27) Long-term health consequences of alcohol use

(13:13) Alcohol's link to hangovers and cancer risk

(15:31) The positive changes from abstaining alcohol

(17:13) Emphasizing mindful alcohol consumption and community support

(18:45) Conclusion and invitation for listener feedback

Office Hours: What Happens to Your Body When You Stop Drinking for 30 Days

This week, in another holiday edition of The Dr. Hyman Show, I’m highlighting a conversation with Dr. Rhonda Patrick, a leading expert in nutritional science and aging — a discussion that still feels incredibly important today. We dig into how hidden micronutrient deficiencies can influence metabolism, mood, longevity, and long-term health. Here’s to supporting our health in the year ahead. 

In this episode, you’ll learn:

• Why vitamin D is essential for longevity, immune health, and mood

• How magnesium influences metabolism, blood sugar, and brain function

• Why even “healthy” diets can leave us undernourished

• What it takes to test and personalize your micronutrient intake

Better aging starts by giving your cells what they’re missing. When your body has the right nutrients, it can repair, renew, and thrive at any stage of life.

Here’s to a healthy start to the new year — I’m excited for what we’ll explore together.

View Show Notes From This Episode

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Sign Up for Dr. Hyman’s Weekly Longevity Journal

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Join the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hive

This episode is brought to you by Seed, PerfectAmino, Function Health, AirDoctor, LMNT and Pique.

Visit seed.com/hyman and use code 20HYMAN for 20% off your first month of Seed's DS-01® Daily Synbiotic.

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Are You Nutrient Deficient? The Hidden Factors of Accelerated Aging | Rhonda Patrick - ENCORE

As we wind down for the holiday season, we’ll be taking a short break. But I didn’t want to leave you without something meaningful to explore. So for today’s Monday episode, we’re revisiting one of our most powerful deep-dive topics of 2025.Thank you for being part of this community. We’ll be back in the new year with brand-new episodes and I truly can’t wait to share what’s coming next.

In today’s episode, we feature four segments about hitting the reset button on our diet and lifestyle choices and establishing new behaviors for our overall wellbeing.

We all get off track sometimes. Life gets busy, we indulge a little too much during the holidays, or we ignore the messages our body is sending us to sleep more and eat better. This can leave us feeling super sluggish, run-down, or unable to think clearly. This is what I call FLC syndrome? It’s when you feel like crap! 

This episode is brought to you by BIOptimizers.

Head to ⁠⁠bioptimizers.com/hyman⁠⁠ and use code HYMAN to save 15%.

Full-length episodes can be found here:

How To Do The 10-Day Detox

Are There Any Healthy Sugars And Sweeteners?

How Much And What Types Of Exercise Are Needed To Age Well?

The Surprising Key To Longevity

How to Get Your Health Back on Track - ENCORE

This week, in a special holiday edition of The Dr. Hyman Show, I’m revisiting a powerful conversation with Dr. Aseem Malhotra, a leading cardiologist and advocate for ethical, evidence-based medicine, where we unpacked the uncomfortable truths about cholesterol, statins, and what really drives heart disease. Wishing you a peaceful holiday week. 

We unpack:

• Why LDL cholesterol isn’t the whole story when it comes to heart disease

• How reducing inflammation and insulin resistance can better protect your heart

• What statins can—and can’t—do to improve real cardiovascular outcomes

• How industry influence shapes the prescriptions patients receive

Better heart health starts with better information and real progress begins when we stop treating numbers and start treating what’s actually causing disease.

Hope you have a peaceful holiday week. I look forward to continuing this journey together in the new year.

View Show Notes From This Episode

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Sign Up for Dr. Hyman’s Weekly Longevity Journal

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Join the 10-Day Detox to Reset Your Health

https://drhyman.com/pages/10-day-detox

Join the Hyman Hive for Expert Support and Real Results

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This episode is brought to you by Big Bold Health, Sunlighten, Function Health and Pique.

Get 20% off HTB Immune Energy Chews at bigboldhealth.com and use code DRMARK20.

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The Cardiologist Who Stopped Prescribing Statins Explains the Real Cause of Heart Attacks | Dr. Aseem Malhotra - ENCORE

As we wind down for the holiday season, we’ll be taking a short break. But I didn’t want to leave you without something meaningful to explore. So for today’s Monday episode, we’re revisiting one of our most powerful deep-dive topics of 2025.Thank you for being part of this community. We’ll be back in the new year with brand-new episodes and I truly can’t wait to share what’s coming next

Did you know that sugar is lurking in more places than you might think, and it could be sabotaging your health in ways you never imagined? In this episode, I look back on my conversations with Dr. Richard Johnson and Dr. Robert Lustig. We examine how certain foods, especially those loaded with sugar, can trigger overeating, disrupt your metabolism, and lead to a cascade of health issues. Plus, I'll share practical strategies for detoxing from sugar, managing blood sugar levels, and reclaiming your health.

⁠This episode is brought to you by BIOptimizers.

Head to ⁠bioptimizers.com/hyman⁠ and use code HYMAN to save 15%.

Full-length episodes of these interviews can be found here:

⁠Why Sugar And Fructose Are So Deadly with Dr. Richard Johnson⁠

⁠Depressed or Anxious? You May Never Eat Sugar Again After Watching This⁠

⁠The True Dangers Of Sugar with Dr. Robert Lustig

(0:00) Introduction and overview of health tools

(0:57) The impact of sugar on weight gain and metabolism

(2:18) Obesity, calorie intake, and food triggers

(7:27) Weight regulation and survival mechanisms in animal studies

(10:05) Processed foods and increased caloric intake

(21:36) Sponsor: Benefits of quitting sugar for 14 days

(23:19) HealthBite on sugar addiction and mental health

(29:05) Gut health and its impact on mental health

(34:20) Steps for a sugar detox and diet composition

(45:29) Supplements, exercise, sleep, and stress management for blood sugar

(47:52) Eight metabolic processes driving chronic disease

(1:04:01) Summary and key to fixing metabolic processes

Why Quitting Sugar Could Save Your Life - ENCORE

Wellness can feel complicated, but most of what matters for long, healthy living is surprisingly simple.

In this episode of The Dr. Hyman Show, I sit down with my longtime friend Dr. Ezekiel “Zeke” Emanuel—oncologist, bioethicist, and author of Eat Your Ice Cream—to explore six core principles that support longevity, from food and movement to social connection and purpose. Zeke shares what we’re getting wrong about wellness, why community matters more than we think, and how small choices can reshape both our health and our healthcare system. Watch the full conversation on YouTube or listen wherever you get your podcasts.

We discuss:

• Why simple habits outperform extreme biohacks—and how to build them into daily life

• How social connection protects your health as powerfully as diet and exercise

• What to eat for longevity without tracking, restricting, or following trends

• How movement, strength, and flexibility each support long-term health and function

• What actually improves sleep when you can’t “try harder” to rest

Longevity isn’t about obsession. It’s about balance, community, and simple choices. The basics still work, and they matter more than ever.

View Show Notes From This Episode

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Sign Up for Dr. Hyman’s Weekly Longevity Journal

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Join the 10-Day Detox to Reset Your Health

https://drhyman.com/pages/10-day-detox

Join the Hyman Hive for Expert Support and Real Results

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This episode is brought to you by Paleovalley, Timeline, Function Health, AirDoctor and BON CHARGE.

Get nutrient-dense, whole foods. Head to paleovalley.com/hyman for 15% off your first purchase.

Support essential mitochondrial health and save 20% on Mitopure. Visit timeline.com/drhyman to get 20% off today.

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(0:00) Introduction to the loneliness epidemic and wellness book critiques

(0:39) Introduction of Dr. Ezekiel Emanuel and his book "Eat Your Ice Cream"

(3:18) Dr. Emanuel's inspiration and contributions to food policy

(5:20) Challenges and critiques in the wellness industry

(7:01) The role of social relationships in health and longevity

(10:11) Simplifying wellness and lessons from longevity hotspots

(13:32) The obsessive focus on wellness and finding balance

(15:32) Dietary impacts on wellness and combating loneliness

(23:53) Strategies for building social connections and community

(30:17) Insights from the Harvard Adult Development Study and other research

(36:24) The role of food in health and the impact of cooking skills

(47:18) The importance of home economics in health education

(51:32) Addressing the health effects of ultra-processed foods

(57:04) The significance of exercise, sleep, and preventive health measures

(1:08:31) Meaning, purpose, and the importance of staying engaged

(1:15:15) Creative rejuvenation and health care system challenges

(1:18:00) Closing remarks and recommendations

6 Simple Rules for a Long, Healthy Life w/ Dr. Ezekiel Emanuel

Ready to feel better than you ever have? Here are five ways to your best health in 2026—simple shifts that work faster than most people realize: food as medicine, restorative sleep, stress mastery, daily movement, and periodic detox resets. Eating real, whole foods sends powerful healing signals to your gut, hormones, and genes, while avoiding processed foods removes the biggest drivers of inflammation. Quality sleep and stress-lowering practices help rebalance cortisol so you can think clearly, feel calmer, and have steady energy throughout the day. Moving your body strengthens your metabolism, protects your brain, and keeps you functional as you age. And short detox periods that remove sugar and processed foods while adding nutrient-dense meals can reboot your entire system and show you just how good “normal” is supposed to feel. When you bring these five pillars together you create momentum that touches every part of your life.

In this episode, I highlight how five simple foundations—food, sleep, stress management, movement, and detox—can completely transform your health, showing that you have far more power to heal and thrive than you’ve ever been told.

This episode is brought to you by BIOptimizers.

Head to bioptimizers.com/hyman and use code HYMAN to save 15%.

Full-length episodes can be found here:How To Use Food As Medicine

How To Stay Asleep And Sleep More Deeply

How Chronic Stress Creates Hormonal Havoc

How Much And What Types Of Exercise Are Needed To Age Well?

How To Do The 10-Day Detox

The 5 Pillars That Will Transform Your Health In 2026

View Show Notes From This Episode
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Sign Up for Dr. Hyman’s Weekly Longevity Journal
Food is more than just fuel - every bite we take has a profound impact on our biology. In this episode, I explain the principles of the Pegan diet, emphasizing the importance of quality, nutrient-dense foods. Joining me are some incredible guests: Dr. Cindy Geyer, a renowned expert in functional medicine, and Dr. Elissa Epel, a leading stress researcher. Together, we'll explore how chronic stress and poor sleep are intricately connected to major health issues like obesity, diabetes, and neurodegenerative diseases. Learn how specific dietary choices can serve as powerful medicine, improving your overall health and longevity. Plus, explore actionable tips and expert insights on integrating these health-boosting foods into your daily routine.
This episode is brought to you by Rupa Health, Neurohacker, and Cymbiotika.
Streamline your lab orders with Rupa Health. Access more than 3,000 specialty lab tests and register for a FREE live demo at RupaHealth.com.
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Eat Smart: Quality Foods to Improve Sleep and Reduce Stress

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