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WNYC Studios

Radiolab is on a curiosity bender. We ask deep questions and use investigative journalism to get the answers. A given episode might whirl you through science, legal history, and into the home of someone halfway across the world. The show is known for innovative sound design, smashing information into music. It is hosted by Lulu Miller and Latif Nasser.

Radiolab

When neuroscientist Madeline Lancaster was a brand new postdoc, she accidentally used an expired protein gel in a lab experiment and noticed something weird. The stem cells she was trying to grow in a dish were self-assembling. The result? Madeline was the first person ever to grow what she called a “cerebral organoid,” a tiny, 3D version of a human brain the size of a peppercorn.

In about a decade, these mini human brain balls were everywhere. They were revealing bombshell secrets about how our brains develop in the womb, helping treat advanced cancer patients, being implanted into animals, even playing the video game Pong. But what are they? Are these brain balls capable of sensing, feeling, learning, being? Are they tiny, trapped humans? And if they were, how would we know?

Special thanks to Lynn Levy, Jason Yamada-Hanff, David Fajgenbaum, Andrew Verstein, Anne Hamilton, Christopher Mason, Madeline Mason-Mariarty, the team at the Boston Museum of Science, and Howard Fine, Stefano Cirigliano, and the team at Weill-Cornell. 

EPISODE CREDITS: 
Reported by - Latif Nasser
with help from - Mona Madgavkar
Produced by - Annie McEwen, Mona Madgavkar, and Pat Walters
with mixing help from - Jeremy Bloom
Fact-checking by - Natalie Middleton and Rebecca Rand
and Edited by - Alex Neason and Pat Walters

EPISODE CITATIONS:

Videos - 

 • “
Growing Mini Brains to Discover What Makes Us Human • ,” Madeline Lancaster’s TEDxCERN Talk, Nov 2015 (
https://zpr.io/6WP7xfA27auR • )
Brain cells playing Pong • (
https://zpr.io/pqgSqguJeAPK • )
Reuters report on CL1 computer launch in March 2025 • (
https://zpr.io/cdMf8Yjvayyd • ) 

Articles - 

Madeline Lancaster: The accidental organoid – mini-brains as models for human brain development • (
https://zpr.io/nnwFwUwnm2p6 • ), MRC Laboratory of Molecular Biology 
What We Can Learn From Brain Organoids • (https://zpr.io/frUfsg4pxKsb), by Carl Zimmer. NYT, November 6, 2025
Ethical Issues Related to Brain Organoid Research • (https://zpr.io/qyiATHEhdnSa), by Insoo Hyun et al, 
Brain Research, • 2020 
Brain organoids get cancer, too, opening a new frontier in personalized medicine • (
https://zpr.io/nqMCQ • ) STAT Profile of Howard Fine and his lab’s glioblastoma research at Weill Cornell Medical Center: 
By re-creating neural pathway in dish, Stanford Medicine research may speed pain treatment • (
https://zpr.io/UnegZeQZfqn2 • ) Stanford Medicine profile of Sergiu Pasca’s research on pain in organoids 
A brief history of organoids • (
https://zpr.io/waSbUCSrL9va • ) by Corrò et al, American Journal of Physiology - Cell Physiology, 

Books - 
Carl Zimmer Life’s Edge: The Search for What it Means to be Alive (https://carlzimmer.com/books/lifes-edge/)

Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Signup (https://radiolab.org/newsletter)!

Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.

Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.

Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

Brain Balls

In 1971, a red-headed, tree-loving astronaut named Stu ‘Smokey’ Roosa was asked to take something to the moon with him. Of all things, he chose to take a canister of 500 tree seeds. After orbiting the moon 34 times, the seeds made it back to Earth. NASA decided to plant the seeds all across the country and then… everyone forgot about them. Until one day, a third grader from Indiana stumbled on a tree with a strange plaque: "Moon Tree." This discovery set off a cascading search for all the trees that visited the moon across the United States. Science writer, and our very own factchecker, Natalie Middleton (https://www.nataliemiddleton.org/) tells us the tale.

Read Lulu’s remembrance of Alice Wong for Transom.org: 13 questions I’ll never get to ask Alice Wong (https://transom.org/2026/13-questions-ill-never-get-to-ask-alice-wong/). 

Check out Natalie’s map to find your nearest moon tree on our show page (https://radiolab.org/podcast/moon-trees)!

Help us hunt for more moon trees. If you know of an undocumented moon tree, contact Natalie at nataliemiddleton.org. Check out Natalie’s essay on Moon Trees (https://orionmagazine.org/article/moon-tree/) and Space Zinnias (https://orionmagazine.org/article/astronaut-scott-kelly-flower-experiment-space/) in Orion Magazine (https://orionmagazine.org/).

Visit NASA’s official Moon Tree Page (https://science.nasa.gov/resource/apollo-moon-trees/) for a list of all the Apollo 14 Moon Trees in the world. 

To learn more about Stu Roosa or to learn more about acquiring your own half Moon Tree, check out the Moon Tree Foundation (https://www.moontreefoundation.com/), spearheaded by Stu’s daughter, Rosemary Roosa. 

A reminder that Terrestrials also makes original music! You can find ‘Tangled in the Roots’ and all other music from the show here (https://www.wnycstudios.org/podcasts/radiolab-kids/just-the-songs).

EPISODE CREDITS: 

Terrestrials was created by Lulu Miller with WNYC Studios. This episode was produced by Tanya Chawla and sound-designed by Joe Plourde. Our Executive Producer is Sarah Sandbach. Our team includes Alan Goffinski, Ana González and Mira Burt-Wintonick. Fact checking was by Diane Kelly. 

Special thanks to Sumanth Prabhaker from Orion magazine, retired NASA Scientist Dr. Dave Williams, Joan Goble, Tre Corely and NASA scientist Dr. Marie Henderson.

Our advisors for this show were Ana Luz Porzecanski, Nicole Depalma, Liza Demby and Carly Ciarrocchi.

Support for Terrestrials also comes from the Simons Foundation, the Arthur Vining Davis Foundations, and the John Templeton Foundation.

Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)!

Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.

Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.
Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

Moon Trees

As she -- and her friends — approached the age of 35, senior correspondent Molly Webster kept hearing a phrase over and over: “fertility cliff.” It was a short-hand term to describe what she was told would happen to her fertility after she turned 35 — that is, it would drop off. Suddenly, sharply, dramatically. And this was well before she was supposed to hit menopause. Intrigued, Molly decided to look into it — what was the truth behind this so-called cliff, and when, if so, would she topple? 

This story first premiered in “Thirty Something,” a 2018 Radiolab live show that was part of, Gonads, (https://radiolab.org/series/radiolab-presents-gonads)a six-episode audio and live event series all about reproduction and the parts of us that make more of us. The live event was produced by Rachael Cusick and edited by Pat Walters.

Special thanks to epidemiologist Lauren Wise, at Boston University. Plus, Emily, Chloe, and Bianca. And of course, Jad Abumrad.

If you’re more of a visual person, here are the graphs we explain in the episode, we also include links to the corresponding papers in our Episode Citations Section, below!

LINK TO GRAPHS:
https://media.wnyc.org/i/1860/1046/c/80/2025/12/FERTILITY_AGE_GRAPHS_1-4.jpg

EPISODE CREDITS: 
Reported by - Molly Webster
Produced by - Arianne Wack
Fact-checking by - Diane A. Kelly

EPISODE CITATIONS:

Audio:

Gonads • (
https://radiolab.org/series/radiolab-presents-gonads/ • )

 • A six-part audio series on reproduction and the parts of us that make more of us
The Menopause Mystery • (
https://radiolab.org/podcast/the-menopause-mystery • )

 • One of Radiolab’s most listened-to episodes of 2025!

 • 

Videos:

“Radiolab Presents: Thirty Something”
https://youtu.be/LOJVAaSwags?si=czCBraHf1JEqmAQi

Research Articles:

 • Graph 1: 
Can assisted reproduction technology compensate for the natural decline in fertility with age? A model assessment • (
https://zpr.io/ft6dqdbkJnTd • )

 • 
 • Graph 2: 
Ovarian aging: mechanisms and clinical consequences • (
https://zpr.io/GrPLebynpvxV • )
 , • Brookmans, et al.
 • BUT, the graph was borrowed and actually comes from this 1991 paper, 
Delaying childbearing: effect of age on fecundity and outcome of pregnancy • ” (
https://zpr.io/whWg2UAZsb6h • ) 

 • 
 • Graph 3 and 4: 
Age and fecundability in a North American preconception cohort study • , (
https://zpr.io/Rmqry4Kd67hY • ) Wise et al; Dutch fertility research

Further reading: 
Predicting Fertility, (https://zpr.io/YEdfiYT29rUh): Magazine article on Lauren Wise’s research,
 

Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Signup (https://radiolab.org/newsletter)!

Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.

Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.
Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

Fertility Cliff

The standard view of evolution is that living things are shaped by cold-hearted competition. And there is no doubt that today's plants and animals carry the genetic legacy of ancestors who fought fiercely to survive and reproduce. But in this hour that we first broadcast back in 2010, we wonder whether there might also be a logic behind sharing, niceness, kindness ... or even, self-sacrifice. Is altruism an aberration, or just an elaborate guise for sneaky self-interest? Do we really live in a selfish, dog-eat-dog world? Or has evolution carved out a hidden code that rewards genuine cooperation?

Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)!

Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.

Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.
Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

The Good Show

It’s faster than a speeding bullet. It’s smarter than a polymath genius. It’s everywhere but it’s invisible. It’s artificial intelligence. But what actually is it?

Today we ask this simple question and explore why it’s so damn hard to answer.

Special thanks to Stephanie Yin and the New York Institute of Go for teaching us the game. Mark, Daria and Levon Hoover Brauner for helping bring NETtalk to life. 

And a huge thank you to Grant Sanderson for his unending patience explaining the math of neural nets to us. To learn more about how these 'thinking machines' actually think, we highly recommend his wonderful youtube channel 3Blue1Brown (https://www.youtube.com/watch?v=aircAruvnKk).

EPISODE CREDITS: 
Reported by - Simon Adler
Produced by - Simon Adler
Original music from - Simon Adler
Sound design contributed by - Simon Adler
Fact-checking by - Anna Pujol-Mazzini 

Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Signup (https://radiolab.org/newsletter)!

Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.

Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.

Leadership support for Radiolab’s science programming is provided by the Gordon and Betty

The Alien in the Room

A year ago we brought you a show called Shell Game where a journalist named Evan Ratliff made an AI copy of himself. Now on season 2 of the show, Evan’s using AI to do more than just mimic himself — he’s starting a company staffed entirely by AI agents, and making a podcast about the experience. The show is a smart, funny, and truly bizarre look at what AI can do—and what it can’t. 

This week we bring you the first episode of Shell Game Season Two, Minimum Viable Company. You can sign up to get the rest of the Shell Game ad-free, and the Shell Game newsletter, at shellgame.co .

EPISODE CREDITS: 

Shell Game 
Hosted by Evan Ratliff, 
Produced and edited by Sophie Bridges. 
Shell Game’s Technical Advisor Matty Bohacek 
Executive Produced by Samantha Henig, Kate Osborn and Mangesh Hattikudur at Kaleidoscope
and Katrina Norvell at IHeart Podcasts.

Radiolab portions 
Hosted by Simon Adler 
Produced by Mona Madgavkar.

Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Signup (https://radiolab.org/newsletter)!

Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.

Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.

Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

Shell Game: Minimum Viable Company

Our original host Jad Abumrad returns to share a new podcast series he’s just released. It’s all about Fela Kuti, a Nigerian musician who created a genre, then a movement, then tried to use his hypnotic beats to topple a military dictatorship. Jad tells us about the series and why he made it, and we play the episode that, for us at least, gets to the heart of the matter: How exactly does his music work? What actually happens to the people who hear it and how does it move them to action?

You can find Jad’s entire nine-part series, Fela Kuti: Fear No Man, on Apple or Spotify, or wherever you get your podcasts.

EPISODE CREDITS: 
Reported by - Jad Abumrad
Radiolab portions produced by - Sindhu Gnanasambandan

Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Signup (https://radiolab.org/newsletter)!

Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.

Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.

Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

Fela Kuti: Enter the Shrine

Today, Lulu and Latif talk about some of their favorite episodes from Radiolab’s past that hold new power today. 

Lulu points to an episode from 2008: 

Imagine that you're a composer. Imagine getting the commission to write a song that will allow family members to face the death of a loved one. Well, composer David Lang had to do just that when a hospital in Garches, France, asked him to write music for their morgue, or 'Salle Des Departs.' What do you do? This piece was produced by Jocelyn Gonzales.

And Latif talks about an episode Jad made in 2009. Here’s how we described it back then:

Jad--a brand new father--wonders what's going on inside the head of his baby Amil.

(And don't worry, you don't need kids to enjoy this podcast.) The questions here are big: what is it like to be so brand new to the world? None of us have memories from this time, so how could we possibly ever know? Is it just chaos? Or, is there something more, some understanding from the very beginning? Jad found a development psychologist named Charles Fernyhough to explore some of his questions.

Support Radiolab by becoming a member today at Radiolab.org/donate.

Deep Cuts

While most of us hear a wall of white noise, squeaks, and squawks....David Rothenberg hears a symphony. He's trained his ear to listen for the music of animals, and he's always looking for chances to join in, with everything from lonely birds to giant whales to swarming cicadas.

In this podcast, David explains his urge to connect and sing along, and helps break down the mysterious life cycle and mating rituals of the periodical cicadas into something we can all relate to.

Support Radiolab by becoming a member today at Radiolab.org/donate.

The Septendecennial Sing-Along

Love it or hate it, the freedom to say obnoxious and subversive things is the quintessence of what makes America America. But our say-almost-anything approach to free speech is actually relatively recent, and you can trace it back to one guy: a Supreme Court justice named Oliver Wendell Holmes. Even weirder, you can trace it back to one seemingly ordinary 8-month period in Holmes’s life when he seems to have done a logical U-turn on what should be say-able. Why he changed his mind during those 8 months is one of the greatest mysteries in the history of the Supreme Court. (Spoiler: the answer involves anarchists, a house of truth, and a cry for help from a dear friend.) Join us as we investigate why he changed his mind, how that made the country change its mind, and whether it’s now time to change our minds again.

This episode was reported by Latif Nasser and was produced by Sarah Qari.

Special thanks to Jenny Lawton, Soren Shade, Kelsey Padgett, Mahyad Tousi and Soroush Vosughi.

Support Radiolab by becoming a member today at Radiolab.org/donate. 

 

further reading:

Thomas Healy’s book The Great Dissent: How Oliver Wendell Holmes CHanged His Mind - And Changed the History of Free Speech In America (the inspiration for this episode) plus his latest book Soul City: Race, Equality and the Lost Dream of an American Utopia.

The Science article that Sinan Aral wrote in 2018, along with Soroush Vosughi and Deb Roy: “The Spread of True and False News Online”

Sinan Aral’s recent book The Hype Machine: How Social Media Disrupts Our Elections, Our Economy and our Health - And How We Must Adapt

Zeynep Tufekci’s newsletter “The Insight” plus her book Twitter and Teargas: The Power and Fragility of Networked Protest

Nabiha Syed’s news website The Markup

Trailer for “The Magnificent Yankee,” a 1950 biopic of Oliver Wendell Holmes

Anthony Lewis, Freedom for the Thought that We Hate: A Biography of the First Amendment

What Up Holmes?

It began with a tweet: “EVERY DAY IS IGNAZ SEMMELWEIS DAY.” Carl Zimmer — tweet author, acclaimed science writer and friend of the show — tells the story of a mysterious, deadly illness that struck 19th century Vienna, and the ill-fated hero who uncovered its cure … and gave us our best weapon (so far) against the current global pandemic.

This episode was reported and produced with help from Bethel Habte and Latif Nasser.

Support Radiolab today at Radiolab.org/donate.

Dispatch 2: Every Day is Ignaz Semmelweis Day

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