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BBC Radio 4

In Our Time: Science

Melvyn Bragg and guests discuss the power-packs within cells in all complex life on Earth. 

Inside each cell of every complex organism there are structures known as mitochondria. The 19th century scientists who first observed them thought they were bacteria which had somehow invaded the cells they were studying. We now understand that mitochondria take components from the food we eat and convert them into energy. 

Mitochondria are essential for complex life, but as the components that run our metabolisms they can also be responsible for a range of diseases – and they probably play a role in how we age. The DNA in mitochondria is only passed down the maternal line. This means it can be used to trace population movements deep into human history, even back to an ancestor we all share: mitochondrial Eve. 

With 

Mike Murphy
Professor of Mitochondrial Redox Biology at the University of Cambridge

Florencia Camus 
NERC Independent Research Fellow at University College London

and 

Nick Lane
Professor of Evolutionary Biochemistry at University College London

Producer Luke Mulhall

Mitochondria

Melvyn Bragg and guests discuss the 2000-year-old device which transformed our understanding of astronomy in ancient Greece. In 1900 a group of sponge divers found the wreck of a ship off the coast of the Greek island of Antikythera. Among the items salvaged was a corroded bronze object, the purpose of which was not at first clear. It turned out to be one of the most important discoveries in marine archaeology. Over time, researchers worked out that it was some kind of astronomical analogue computer, the only one to survive from this period as bronze objects were so often melted down for other uses. In recent decades, detailed examination of the Antikythera Mechanism using the latest scientific techniques indicates that it is a particularly intricate tool for showing the positions of planets, the sun and moon, with a complexity and precision not surpassed for over a thousand years.

With 

Mike Edmunds 
Emeritus Professor of Astrophysics at Cardiff University

Jo Marchant 
Science journalist and author of 'Decoding the Heavens' on the Antikythera Mechanism

And 

Liba Taub 
Professor Emerita in the Department of History and Philosophy of Science at the University of Cambridge and Visiting Scholar at the Deutsches Museum, Munich

Producer: Simon Tillotson
In Our Time is a BBC Studios Audio Production

Reading list:

Derek de Solla Price, Gears from the Greeks: The Antikythera Mechanism (American Philosophical Society Press, 1974)

M. G. Edmunds, ‘The Antikythera mechanism and the mechanical universe’ (Contemp. Phys. 55, 2014) 

M.G. Edmunds, ’The Mechanical Universe’ (Astronomy & Geophysics, 64, 2023)

James Evans and J. Lennart Berggren, Geminos's Introduction to the Phenomena: A Translation and Study of a Hellenistic Survey of Astronomy (Princeton University Press, 2006)

T. Freeth et al., ‘Calendars with Olympiad display and eclipse prediction on the Antikythera mechanism’ (Nature 454, 2008)

Alexander Jones, A Portable Cosmos: Revealing the Antikythera Mechanism, Scientific Wonder of the Ancient World (Oxford University Press, 2017)

Jo Marchant, Decoding the Heavens: Solving the Mystery of the World’s First Computer (Windmill Books, 2009)

J.H. Seiradakis and M.G. Edmunds, ‘Our current knowledge of the Antikythera Mechanism’ (Nature Astronomy 2, 2018)

Liba Taub, Ancient Greek and Roman Science: A Very Short Introduction (Oxford University Press, 2022)

The Antikythera Mechanism

Melvyn Bragg and guests discuss some of the great unanswered questions in science: how and where did life on Earth begin, what did it need to thrive and could it be found elsewhere? Charles Darwin speculated that we might look for the cradle of life here in 'some warm little pond'; more recently the focus moved to ocean depths, while new observations in outer space and in laboratories raise fresh questions about the potential for lifeforms to develop and thrive, or 'habitability' as it is termed. What was the chemistry needed for life to begin and is it different from the chemistry we have now? With that in mind, what signs of life should we be looking for in the universe to learn if we are alone?

With 

Jayne Birkby
Associate Professor of Exoplanetary Sciences at the University of Oxford and Tutorial Fellow in Physics at Brasenose College

Saidul Islam
Assistant Professor of Chemistry at Kings College, London

And 

Oliver Shorttle
Professor of Natural Philosophy at the University of Cambridge and Fellow of Clare College

Producer: Simon Tillotson

Reading list: 

David Grinspoon, Venus Revealed: A New Look Below the Clouds of Our Mysterious Twin Planet (Basic Books, 1998)

Lisa Kaltenegger, Alien Earths: Planet Hunting in the Cosmos (Allen Lane, 2024)

Andrew H. Knoll, Life on a Young Planet: The First Three Billion Years of Evolution on Earth (‎Princeton University Press, 2004)

Charles H. Langmuir and Wallace Broecker, How to Build a Habitable Planet: The Story of Earth from the Big Bang to Humankind (Princeton University Press, 2012)

Joshua Winn, The Little Book of Exoplanets (Princeton University Press, 2023)

In Our Time is a BBC Studios Audio Production

The Habitability of Planets

Melvyn Bragg and guests discuss slime mould, a basic organism that grows on logs, cowpats and compost heaps. Scientists have found difficult to categorise slime mould: in 1868, the biologist Thomas Huxley asked: ‘Is this a plant, or is it an animal? Is it both or is it neither?’ and there is a great deal scientists still don’t know about it.
 
But despite not having a brain, slime mould can solve complex problems: it can find the most efficient way round a maze and has been used to map Tokyo’s rail network. Researchers are using it to help find treatments for cancer, Parkinson's and Alzheimer's disease, and computer scientists have designed an algorithm based on slime mould behaviour to learn about dark matter. It’s even been sent to the international space station to help study the effects of weightlessness.
 
With

Jonathan Chubb
Professor of Quantitative Cell Biology at University College, London

Elinor Thompson
Reader in microbiology and plant science at the University of Greenwich

And

Merlin Sheldrake
Biologist and writer

Producer: Eliane Glaser 

In Our Time is a BBC Studios Audio production

Slime Moulds

Since plants have to mate and produce offspring while rooted to the spot, they have to be pollinated – by wind, water, or animals – most commonly insects. They use a surprising array of tricks to attract pollinators: striking colours, iridescent light effects, and enticing scents, to name but a few. 

Insects, on the other hand, do not seek to pollinate plants – they are looking for food; so plants make sure it’s worth their while. Insects are also remarkably sophisticated in their ability to find, recognise and find their way inside flowers. 

So pollination has evolved as a complex dance between plants and pollinators that is essential for life on earth to continue. 

With 

Beverley Glover, Director of the Cambridge University Botanic Garden

Jane Memmott, Professor of Ecology at the University of Bristol

And

Lars Chittka, Professor of Sensory and Behavioural Ecology at Queen Mary, University of London.

Producer: Eliane Glaser

Reading list:

Stephen L Buchmann and Gary Paul Nabhan, The Forgotten Pollinators (Island Press, 1997)

Lars Chittka, The Mind of a Bee (Princeton University Press, 2023)

Steven Falk, Field Guide to the Bees of Britain and Ireland (British Wildlife Publishing, 2015)

Francis S. Gilbert (illustrated by Steven J. Falk), Hoverflies: Naturalists' Handbooks vol. 5 (Pelagic Publishing, 2015)

Dave Goulson, A Sting in the Tale: My Adventures with Bumblebees (Vintage, 2014)

Edwige Moyroud and Beverley J. Glover, ‘The evolution of diverse floral morphologies’ (Current Biology vol 11, 2017)

Jeff Ollerton, Birds and Flowers: An Intimate 50 Million Year Relationship (Pelagic Publishing, 2024)
 
Alan E. Stubbs and Steven J. Falk, British Hoverflies (‎British Entomological & Natural History Society, 2002)

Timothy Walker, Pollination: The Enduring Relationship Between Plant and Pollinator (Princeton University Press, 2020)

In Our Time is a BBC Studios Audio Production

Pollination

Melvyn Bragg and guests discuss whether the mass of scientific understanding and knowledge we have accumulated has destroyed our sense of poetic wonder at the world. Has our sense of awe at how the world works obscured our desire to know why it works the way it does? With Richard Dawkins evolutionary biologist, reader in Zoology and Fellow of New College, Oxford, Charles Simonyi Chair of Public Understanding of Science, Oxford University and author of Unweaving The Rainbow: Science, Delusion and The Appetite For Wonder; Ian McEwan, novelist, and author of the Booker prize winning novel Amsterdam.

Science's Revelations

Melvyn Bragg and guests discuss how perceptions of science and the power of science have changed in the 20th century. Does scientific endeavour increasingly concern itself with doubt rather than certainty, and is it coming any closer to integrating with other disciplines - philosophy or the social sciences? How much does the scientific explanation of the world owe to a wish for coherent understanding we all have, rather than objective observation, and why are we alternately disapproving of, then obsessively over-enthusiastic about new scientific theories? How far has specialisation in the sciences obscured our view of the world in its entirety, and if scientists want to operate within a social framework, can they do so and still claim to be objective and value-free in their findings?With John Gribbin, Visiting Fellow in Astronomy, University of Sussex and consultant to New Scientist; Mary Midgley, moral philosopher and former Senior Lecturer in Philosophy, University of Newcastle.

Science in the 20th century

Melvyn Bragg and guests discuss how our increased knowledge of the functioning of the brain and the mechanisms of memory in the 20th century has changed our feelings about our own natures, and our approach to the behaviour and treatment of others.Many questions have been thrown up this century by our growing knowledge about how the brain and the mind function. How easy is it to establish the relationship between the two, and what light can this relationship throw on our understanding of our own and others natures? With Steven Rose, Professor of Biology and Director of the Brain and Behaviour Research Group, Open University, Dan Robinson, Distinguished Research Professor, Georgetown University and visiting lecturer in Philosophy and Senior Member of Linacre College, Oxford University.

The Brain and Consciousness

Melvyn Bragg and guests marvel at our brains and discuss how at the end of a century of research we still understand so little about how they work.Developments in the understanding of the brain represent one of the major leaps forward in science in the 20th century, and the research is gathering pace and intensity. It’s a subject which captures the imagination, particularly the search for consciousness whatever that might be, and brings together some of the newest technology and the oldest belief systems. What a piece of work is the brain - a grain-of-sand-sized piece contains one hundred thousand neurons, two-million axons and one billion synapses which all talk to each other. How far we have got with our understanding of the brain and what can it tell us about ourselves and the world we live in?With Professor Susan Greenfield, director of the Royal Institution, Professor of Pharmacology, Oxford University and Professor of Physics at Gresham College; Professor Vilayanur Ramachandran, Professor of Neuroscience and Psychology, Director of the Brain Perception Laboratory, University of California in San Diego and Professor at the Salk Institute.

Neuroscience in the 20th century

Melvyn Bragg and guests discuss the implications of the developments in genetic engineering. Out of the city of Cambridge in the mid century came DNA and out of Edinburgh at the end of the century came the cloning of Dolly the sheep. These two facts might well do more to change the world literally, and our view of the world, than anything else that has happened at any time. Genetics have become the conversation of our day and with the Human Genome Project lumbering towards completion, its power grows. But are the consequences likely to be destructive and will what we think of as a human being, a personality, or even a person, change uncomfortably and irredeemably? With Grahame Bulfield, geneticist, honorary professor, Edinburgh University and Director of the Roslin Institute, Edinburgh; Bryan Appleyard, features writer for The Sunday Times and author of Brave New Worlds: Genetics and the Human Experience.

Genetic Engineering

Melvyn Bragg and guests discuss some of the chemical signals coursing through our bodies throughout our lives, produced in separate areas and spreading via the bloodstream. We call these 'hormones' and we produce more than 80 of them of which the best known are arguably oestrogen, testosterone, adrenalin, insulin and cortisol. On the whole hormones operate without us being immediately conscious of them as their goal is homeostasis, maintaining the levels of everything in the body as required without us having to think about them first. Their actions are vital for our health and wellbeing and influence many different aspects of the way our bodies work.

With

Sadaf Farooqi
Professor of Metabolism and Medicine at the University of Cambridge

Rebecca Reynolds
Professor of Metabolic Medicine at the University of Edinburgh

And

Andrew Bicknell
Associate Professor in the School of Biological Sciences at the University of Reading

Produced by Victoria Brignell

Reading list:

Rachel Carson, Silent Spring (first published 1962; Penguin Classics, 2000)

Stephen Nussey and Saffron Whitehead, Endocrinology: An Integrated Approach (BIOS Scientific Publishers; 2001)

Aylinr Y. Yilmaz, Comprehensive Introduction to Endocrinology for Novices (Independently published, 2023)

Hormones

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