Robust disease surveillance systems are the foundation of strong public health systems and are essential to preventing, detecting, and responding to health threats before they escalate. Commitments to and investments in quality disease surveillance systems are key to smart, cost-effective public health decision-making, which is needed more than ever. Before the Outbreak is a three-part podcast series produced in partnership between Global Dispatches and the United Nations Foundation, in which we explore how the world sees, anticipates, and prepares for current and emerging health threats. Through stories and science, this series highlights the critical functions that protect us – before the outbreak begins. Our debut episode features the expertise of Dr. Ciro Ugarte, Director of Health Emergencies at the Pan American Health Organization, and Dr. Pardis Sabeti, a professor at Harvard University's School of Public Health. We begin by defining our terms—that is, what do we mean by disease surveillance? We then discuss how disease surveillance works in practice and what can be done to strengthen our global defenses against the next pandemic.