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BBC World Service

Discovery

Many people will be familiar with Parkinson’s disease: the progressive brain disorder that causes symptoms including tremors and slower movement, leading on to serious cognitive problems. You might not know that it’s the fastest-growing neurological condition in the world. Today it affects around 11.8 million people and that’s forecast to double by 2030. Dr Sonia Gandhi is one of the scientists working to change that trend. As Professor of Neurology at University College London and Assistant Research Director at the Francis Crick Institute, her work involves using stem cells to build models of the human brain, helping to drive the development of drugs and other therapies for Parkinson’s patients. Talking to Professor Jim Al-Khalili, Sonia explains why this destructive condition is on the rise - and the promising routes they're studying to find new ways to tackle it.

The Life Scientific: Sonia Gandhi

How do you feel about snakes? What about highly venomous ones?

For Mark O’Shea, close encounters with the world’s most rare and deadly snakes are not only his profession, but his passion.
Mark is a Professor of Herpetology - the area of zoology focusing on reptiles and amphibians - at the University of Wolverhampton.

After dropping out of college in his teens, Mark's life could have taken a very different direction; but prompted by a fascination with reptiles that started with a childhood trip to the zoo, he's gone on to have a career spanning research, international expeditions and broadcasting. He's also worked with international medical teams, studying deadly species and helping to generate antidotes for some of the world’s deadliest venoms.

In conversation with Professor Jim Al-Khalili, Mark reveals the challenges around generating antivenom for countries that need it, the pros and cons of keeping snakes as pets, and what you need to know if you ever get bitten...

Presented by Jim Al-Khalili
Produced by Lucy Taylor

The Life Scientific: Mark O'Shea

What’s it like to wake up with a brand new voice? For those with foreign accent syndrome, this is their reality. Patients who develop this rare speech disorder start speaking in a brand new accent that they often have no connection to.

So how does losing the voice you’ve known your entire life shape, or break, your identity?

Presenter Ella Hubber speaks to Althia Bryden, who developed foreign accent syndrome last year, and Sarah Colwill, who has lived with the condition for the past 15 years. They share the deep impact it has had on their identity and connection to those around them.

And to understand what is happening in the brain to cause this complete change in accent, and whether it’s really even an accent at all, Ella speaks to professor Nicholas Miller, who has been unpicking the mystery of foreign accent syndrome for decades. Also, professor Stefanie Keulen shares that there are actually multiple types of the condition.

Even though foreign accent syndrome is rare, it is found around the world, can affect anyone, and highlights just how deeply our voices influence all aspects of our lives.

Presenter: Ella Hubber
Producers: Sophie Ormiston, Ella Hubber
Assistant Producer: Minnie Harrop
Editor: Martin Smith

Waking up with a different voice

We live in a time of automation and robotics; the machines run the factories, and AI will soon take all the jobs. Yet, even today, there are certain niche jobs where only an animal will do. Comedian and biologist Simon Watt meets some of them and the people who train them, study them, and love them. 

He starts with a business of ferrets (yes, that is their collective noun) at the National Ferret School in Derbyshire, who have swapped rabbit holes and trouser legs for drain-clearing, rewiring, and laying fibre optic cables. Ferret Trainer James McKay demonstrates why they are perfect for the job, as he casually folds one trainee into a tight pretzel.

Simon visits the HQ of Medical Detection Dogs, a training facility in Milton Keynes where dogs are being trained to sniff the tell-tale signs of a host of diseases. You may have heard of their 'cancer dogs', but it goes much further - epilepsy, malaria, Parkinson's, even Covid-19. Dr Claire Guest explains.

Although we have no real idea exactly how dogs do what they do, AI may be on the cusp of solving this puzzle for us. Simon speaks to Dr Andreas Mershin from start-up Realnose, which is developing “electronic noses".

Finally, Simon meets some real heroes - HeroRats, to be precise. Not the same species that haunts our sewers, these are African Giant Pouched Rats, and their job as landmine detection specialists is saving lives across Thailand, Mozambique, Cambodia and Zimbabwe. Dr Cynthia Fast from UCLA trains them for the job.

Presenter: Simon Watt 
Producer: Emily Knight

The animal employment agency

The London Anatomy Office accepts around 350 human bodies donated for medical research and education annually. You may imagine that these bodies are presevered in chemicals for medical students to study over weeks and months. And some are. But many are used - almost fresh - to train surgeons in the procedures which may one day save your life.

Journalist Jenny Kleeman gains rare access to a surgical training course at Brighton and Sussex Medical School which uses these "fresh" donor bodies. She talks to the people who work with them every day and the surgeons who have come to be trained to find out how they feel about the people who have given the ultimate gift and if we still need real human cadavers in medical education.

Presenter: Jenny Kleeman
Producer: Ella Hubber

Bodies

There can't be many people in the world who've saved lives in hospital emergency rooms and also helped care for the wellbeing of astronauts in space – but Kevin Fong’s career has followed a singular path: from astrophysics and trauma medicine, to working with NASA, to becoming an Air Ambulance doctor.

Kevin is a consultant anaesthetist and professor of public engagement and innovation at University College London. He’s worked on the front line in hospitals, dealing with major incidents and helping shape policy; but he's also stayed true to his childhood passion for space, working on multiple projects with NASA and even going through the astronaut application process himself. As if that wasn’t enough, he’s also become a well-known figure in science broadcasting through his various radio and TV shows.

Speaking to Professor Jim Al-Khalili, Kevin admits it hasn't always been an easy path – but his passion for both space and medicine have got him through. And today, he's channelling his energies into ensuring we protect the NHS's most precious commodity: its staff.

Presented by Jim Al-Khalili
Produced by Lucy Taylor
Revised for World Service by Minnie Harrop

The Life Scientific: Kevin Fong

Chemical reactions are the backbone of modern society: the energy we use, the medicines we take, our housing materials, even the foods we eat, are created by reacting different substances together. If we zoom in, it’s the atoms within these substances that rearrange themselves to give rise to new substances with the properties we need.

However, chemical reactions are far from perfect. They're often inefficient and their waste products can be harmful to the environment. Getting to grips with what goes on at the scale of individual atoms has long been a sticking point.

Dame Pratibha Gai has spent much of her career pioneering novel microscopes to bring this seemingly inaccessible atomic world into sharp focus. Now Emeritus Professor of Chemistry at York University, her microscope, known as the environmental transmission electron microscope, is housed in labs around the world. It allows scientists, like herself, to observe chemical reactions in real-time, in exquisite atomic detail, and tinker with them to create products that are not only better for all of us, but also the environment.

Presented by Jim Al-Khalili
Produced by Beth Eastwood
Revised for World Service by Minnie Harrop

The Life Scientific: Dame Pratibha Gai

Have you ever considered the lighter side of dark matter?
Comedy has proved an unexpectedly succesful way to engage people with science - as today's guest knows first-hand.

Astrophysicist Catherine Heymans is a Professor at the University of Edinburgh and the current Astronomer Royal for Scotland. She’s spent her career studying dark matter and dark energy: the mysterious ingredients that make up an estimated 95% of our cosmos, but which we still know surprisingly little about. Using increasingly powerful telescopes, both on earth and in space, Catherine has spent years building detailed maps of dark matter - even to the extent of capturing rare images of this mysterious cosmic component.

On top of her research achievements, she's committed to making science accessible to all; not least by taking an astronomy-themed comedy show to the Edinburgh Festival and beyond.

In conversation with Professor Jim Al-Khalili, Catherine talks about her passion for sharing the joys of astrophysics - and reveals how health challenges over the last few years have forced her to readdress her career, her ambitions and even her sense of self...

Presented by Jim Al-Khalili
Produced by Lucy Taylor
Revised for World Service by Minnie Harrop

The Life Scientific: Catherine Heymans

As a young man, traveling in Africa, Tim Coulson - now Professor of Zoology at the University of Oxford - became seriously ill with malaria and was told a second bout would probably kill him. Aged only 20, this brush with his own mortality led him to promise himself he would write a complete guide to science: life, the universe and everything. His aim was to understand the existence of all living things - no mean feat!

Over the course of a colourful career, Tim's work has taken him all over the world: including researching wolves in Yellowstone National Park, little fish called guppies in the rivers of Trinidad and silvereye birds on Heron Island on the Great Barrier Reef. Using complicated mathematical models he builds up a picture of ecosystems seeking to explain how predators impact both evolution and ecosystems. And finally, more than thirty years after he vowed to write the book that would explain everything we know about science, he's done just that.

In conversation with Professor Jim Al-Khalili, Tim talks about his journey from youthful ambition to science demystifier.

Presented by Jim Al-Khalili
Produced by Geraldine Fitzgerald
Revised for World Service by Minnie Harrop

The Life Scientific: Tim Coulson

Have you ever pondered the fact that the universe is expanding? And not only that, it's expanding at an increasing speed - meaning everything around us is getting further and further away? 

If that isolating thought makes you feel slightly panicked, don't worry: this programme also contains wine! 

Brian Schmidt is a Distinguished Professor of Astrophysics at the Australian National University, known for his work on supernovae: massive explosions that take place when stars come to the ends of their lives. They are among the most energetic events in the universe and incredibly difficult to find; but that’s what his High-Z Supernova Search Team did, identifying enough of these rare and distant explosions to measure just how fast they were moving away from us. 

This led them to the realisation that, contrary to long-held belief in cosmology, the expansion of the universe was speeding up; a discovery which earned Brian a share of the 2011 Nobel Prize for Physics. As if that wasn't enough, he's gone on to discover one of the earliest stars in the universe; run a university; and become a winemaker, at his very own vineyard just outside Canberra. 

In a conversation spanning the genius phraseology of writer Douglas Adams, the importance of pisco sours, and the similarities between astronomy and viticulture, Brian tells Professor Jim Al-Khalili how his supernovae breakthrough paved the way for a revolution in astronomy - and where the field needs to go next... 

Presented by Jim Al-Khalili 
Produced for BBC Studios by Lucy Taylor
Revised for World Service by Minnie Harrop

The Life Scientific: Brian Schmidt

You might think that sex is essential for life, but you'd be wrong!

Lucy Cooke travels to the Hawaiian island of Oahu to meet a community of mourning geckos - self-cloning sisters who have done away with males altogether.

An array of reptiles, amphibians and fish, along with a host of spineless wonders, from snails to spiders, can reproduce without sex. It's what biologists call parthenogenesis, from the Greek meaning “virgin birth”.

Many, like the mourning gecko, make great “weed” species. They're explosive opportunists capable of rapidly colonising new territory, as they don’t need to waste energy finding a mate. But without the mixing up of genes, that sex with a male provides, they are less able to adapt and change.

So sex pays if you don’t want to go extinct.

Yet there is one self-cloning sister that defies that theory - the Bdelloid Rotifer. Living for millions of years and comprising over 450 species, these microscopic water dwelling creatures have conquered the planet. They get around the drawbacks of no sex, by stealing genes, and escape disease by desiccating and then coming back to life.

Producer: Beth Eastwood

Picture: Female Komodo dragon at London Zoo, Credit: Matthew Fearn/PA

The power of celibacy

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