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BBC World Service

Discovery

Chemical reactions are the backbone of modern society: the energy we use, the medicines we take, our housing materials, even the foods we eat, are created by reacting different substances together. If we zoom in, it’s the atoms within these substances that rearrange themselves to give rise to new substances with the properties we need.

However, chemical reactions are far from perfect. They're often inefficient and their waste products can be harmful to the environment. Getting to grips with what goes on at the scale of individual atoms has long been a sticking point.

Dame Pratibha Gai has spent much of her career pioneering novel microscopes to bring this seemingly inaccessible atomic world into sharp focus. Now Emeritus Professor of Chemistry at York University, her microscope, known as the environmental transmission electron microscope, is housed in labs around the world. It allows scientists, like herself, to observe chemical reactions in real-time, in exquisite atomic detail, and tinker with them to create products that are not only better for all of us, but also the environment.

Presented by Jim Al-Khalili
Produced by Beth Eastwood
Revised for World Service by Minnie Harrop

The Life Scientific: Dame Pratibha Gai

Have you ever considered the lighter side of dark matter?
Comedy has proved an unexpectedly succesful way to engage people with science - as today's guest knows first-hand.

Astrophysicist Catherine Heymans is a Professor at the University of Edinburgh and the current Astronomer Royal for Scotland. She’s spent her career studying dark matter and dark energy: the mysterious ingredients that make up an estimated 95% of our cosmos, but which we still know surprisingly little about. Using increasingly powerful telescopes, both on earth and in space, Catherine has spent years building detailed maps of dark matter - even to the extent of capturing rare images of this mysterious cosmic component.

On top of her research achievements, she's committed to making science accessible to all; not least by taking an astronomy-themed comedy show to the Edinburgh Festival and beyond.

In conversation with Professor Jim Al-Khalili, Catherine talks about her passion for sharing the joys of astrophysics - and reveals how health challenges over the last few years have forced her to readdress her career, her ambitions and even her sense of self...

Presented by Jim Al-Khalili
Produced by Lucy Taylor
Revised for World Service by Minnie Harrop

The Life Scientific: Catherine Heymans

As a young man, traveling in Africa, Tim Coulson - now Professor of Zoology at the University of Oxford - became seriously ill with malaria and was told a second bout would probably kill him. Aged only 20, this brush with his own mortality led him to promise himself he would write a complete guide to science: life, the universe and everything. His aim was to understand the existence of all living things - no mean feat!

Over the course of a colourful career, Tim's work has taken him all over the world: including researching wolves in Yellowstone National Park, little fish called guppies in the rivers of Trinidad and silvereye birds on Heron Island on the Great Barrier Reef. Using complicated mathematical models he builds up a picture of ecosystems seeking to explain how predators impact both evolution and ecosystems. And finally, more than thirty years after he vowed to write the book that would explain everything we know about science, he's done just that.

In conversation with Professor Jim Al-Khalili, Tim talks about his journey from youthful ambition to science demystifier.

Presented by Jim Al-Khalili
Produced by Geraldine Fitzgerald
Revised for World Service by Minnie Harrop

The Life Scientific: Tim Coulson

Have you ever pondered the fact that the universe is expanding? And not only that, it's expanding at an increasing speed - meaning everything around us is getting further and further away? 

If that isolating thought makes you feel slightly panicked, don't worry: this programme also contains wine! 

Brian Schmidt is a Distinguished Professor of Astrophysics at the Australian National University, known for his work on supernovae: massive explosions that take place when stars come to the ends of their lives. They are among the most energetic events in the universe and incredibly difficult to find; but that’s what his High-Z Supernova Search Team did, identifying enough of these rare and distant explosions to measure just how fast they were moving away from us. 

This led them to the realisation that, contrary to long-held belief in cosmology, the expansion of the universe was speeding up; a discovery which earned Brian a share of the 2011 Nobel Prize for Physics. As if that wasn't enough, he's gone on to discover one of the earliest stars in the universe; run a university; and become a winemaker, at his very own vineyard just outside Canberra. 

In a conversation spanning the genius phraseology of writer Douglas Adams, the importance of pisco sours, and the similarities between astronomy and viticulture, Brian tells Professor Jim Al-Khalili how his supernovae breakthrough paved the way for a revolution in astronomy - and where the field needs to go next... 

Presented by Jim Al-Khalili 
Produced for BBC Studios by Lucy Taylor
Revised for World Service by Minnie Harrop

The Life Scientific: Brian Schmidt

The celebrated primatologist Jane Goodall died last week at the age of 91. In tribute, we’re re-sharing this interview from 2020, where she reflects on the years she spent living with the wild chimpanzees in Gombe in eastern Tanzania and why she believes the best way to bring about change is to ‘creep into people’s hearts’. 

Jane shot to fame when she appeared on the cover of National Geographic magazine in 1963 and appeared in a documentary film directed by Orson Welles. Her ground breaking observations introduced us to the social and emotional lives of wild chimpanzees and changed our view of what it is to be human. Images of her younger self play-wrestling with baby chimps make Jane feel slightly apprehensive now but at the time she didn’t give it a second thought. However, she did take care to protect her young son. Seeing distressing footage of chimps who were living in captivity, she gave up fieldwork to become an activist, working to liberate chimpanzees that were being used for medical research or sold for meat or as pets, and setting up chimp sanctuaries for animals that were no longer able to live in the wild. For the last thirty years, she has campaigned gently but relentlessly to protect wild animals and wild places, touring the world and performing on stage in front of huge audiences. Her global youth programme, Roots and Shoots has inspired and empowered millions of people to understand and respect nature, leading some to call her ‘the mother Theresa of the environment’. A label she dislikes.

Producer: Anna Buckley

The Life Scientific: Jane Goodall

How much information can you extract from a burnt fragment of human bone?

Quite a lot, it turns out - not only about the individual, but also their broader lives and communities; and these are the stories unearthed by Jacqueline McKinley, a Principal Osteoarchaeologist with Wessex Archaeology.

During her career, Jackie has analysed thousands of ancient burial sites across the British Isles, bringing to life the old traditions around death via often cremated human remains. She's also assisted criminal investigators with forensic analysis, and contributed to some of the UK's best-loved archaeological TV shows.
And one thing she’s absolutely clear about: far from being macabre, osteoarchaeology is more about the living, than the dead...

In conversation with Professor Jim Al-Khalili, Jackie talks about the stories we can derive from skeletal remains, how western attitudes to death have gone through a major recent shift, and why she's kept some of her late father's bones.

Presented by Jim Al-Khalili
Produced for BBC Studios by Lucy Taylor
Reversion for World Service by Minnie Harrop

The Life Scientific: Jacqueline McKinley

Surgeons often have to deal with the consequences of violent attacks - becoming all too familiar with patterns of public violence, and peaks around weekends, alcohol-infused events and occasions that bring together groups with conflicting ideals.

Professor Jonathan Shepherd not only recognised the link between public violence and emergency hospital admissions, he actually did something about it.

As a senior lecturer in Oral and Maxillofacial Surgery in the early 1980s, Jonathan started looking into this trend - and his research revealed that most violent assaults resulting in emergency hospital treatment are not reported to police.

As a result, he devised the ‘Cardiff Model for Violence Prevention’: a programme where hospitals share data about admissions relating to violent attacks with local authorities. He also went on to study various aspects of violent assault and deliver evidence-based solutions - from alcohol restrictions in hotspots, to less breakable beer glasses in pubs.

The impacts have been significant, delivering reductions in hospital admissions and in violent attacks recorded by police; not only in Cardiff, but in cities around the world where the model is used. Today, as an Emeritus Professor of Oral and Maxillofacial Surgery at Cardiff University - where he’s also Director of their Crime, Security and Intelligence Innovation Institute - Jonathan continues to bring together the medical sector with local authorities, finding practical ways to make cities and their residents safer.

But his career, straddling the worlds of practise, science and policy, is an unusual one; here he talks to Professor Jim Al-Khalili about what drove him to make a difference.

Presentedby Jim Al-Khalili
Produced by Lucy Taylor
Reversion for World Service by Minnie Harrop

The Life Scientific: Jonathan Shepherd

Doyne Farmer is something of a rebel. Back in the seventies, when he was a student, he walked into a casino in Las Vegas, sat down at a roulette table and beat the house. To anyone watching the wheel spin and the ball clatter to its final resting place, his choice of number would’ve looked like a lucky guess. But knowing the physics of the game and armed with the world’s first wearable computer, which he’d designed, a seemingly random win was actually somewhat predictable.

Doyne is an American scientist and entrepreneur who pioneered many of the fields that define the scientific agenda of our time, from chaos theory and complex systems to wearable computing. He uses big data and evermore powerful computers to apply complex systems science to the economy, to better predict our future. Much like roulette, economics can appear random but, with the right tools and understanding, it is anything but.

Now Director of the Complexity Economics Programme at the Institute for New Economic Thinking at Oxford, Doyne says there’s a real need to act, to use these powers of prediction to help resolve one of the most pressing questions of our time - how best to prevent climate change.

Presented by Jim Al-Khalili
Produced by Beth Eastwood
Reversion for World Service by Minnie Harrop

The Life Scientific: Doyne Farmer

Elephants are the largest living land mammal and today our planet is home to three species: the African bush elephant, the African forest elephant, and the Asian elephant.

But a hundred thousand years ago, in the chilly depths of the Ice Age, multiple species of elephant roamed the earth: from dog-sized dwarf elephants to towering woolly mammoths.

These gentle giants' evolutionary story and its parallels with that of humankind has long fascinated Dr Tori Herridge, a senior lecturer in evolutionary biology at the University of Sheffield, where - as a seasoned science broadcaster - she's also responsible for their Masters course in Science Communication.

Tori has spent much of her life studying fossil elephants and the sites where they were excavated; trying to establish facts behind relics that are far beyond the reach of Radio Carbon Dating. To date she's discovered dwarf mammoths on Mediterranean islands, retraced the groundbreaking Greek expedition of a female palaeontologist in the early 1900s, and even held an ancient woolly mammoth’s liver. (Verdict: stinky.)

But as she tells Professor Jim Al-Khalili, this passion for fossil-hunting is not just about understanding the past: this information is what will help us protect present-day elephants and the world around them for future generations.

Presented by Jim Al-Khalili
Produced for BBC Studios by Lucy Taylor
Reversion for World Service by Minnie Harrop

The Life Scientific: Tori Herridge

What does it take to earn the nickname, ‘The Leonardo da Vinci of heart surgery’?

That's the moniker given to today's guest - a man who pioneered high-profile and often controversial procedures, but also helped drive huge medical progress; carrying out around 2,000 heart transplants and 400 dual heart-lung transplants during his 60-year career.

Sir Magdi Yacoub is Emeritus Professor of Cardiothoracic Surgery at Imperial College London, and Director of Research at Harefield Hospital’s Magdi Yacoub Institute.
Inspired by a surgeon father and impacted by the tragic early death of his aunt from a heart condition, his medical career includes various surgical firsts alongside numerous research projects, to further our understanding of and ability to treat heart disease. He headed up the teams that discovered it is possible to reverse heart failure, and that successfully grew part of a human heart valve from stem cells for the first time.

But it hasn't always been plain sailing. At times, his work – such as early, unsuccessful transplant attempts, or using a baboon as a life-support system for a baby – attracted serious public criticism.

Speaking to Professor Jim Al-Khalili, Sir Magdi reflects on the highs and lows of his cardio career, and offers his advice to the next generation of surgeons and researchers hoping to make their mark in heart medicine.

Presented by Jim Al-Khalili
Produced by Lucy Taylor
Reversion for World Service by Minnie Harrop

The Life Scientific: Sir Magdi Yacoub

Gene therapy - repairing malfunctioning cells by mending their DNA - offers an elegant solution to diseases, such as cystic fibrosis, caused by a single flawed gene. 

It's a very simple concept to describe - simply insert a 'normal' gene to do the job - but it's this process, the delivery of the gene, that's proving to be so difficult and time consuming. Since the first human study began in 1990 the field has struggled with various technical challenges and set-backs.

But over a decade on, researchers are beginning to report successes in treating several devastating diseases. Geoff Watts finds out about some of the new techniques for gene therapy, and discovers how these are now being used in a trial of a new method of gene therapy for cystic fibrosis. 

Twelve years ago, a group of scientists from Imperial College in London, Oxford and Edinburgh formed the Cystic Fibrosis Gene Therapy Consortium. This year they started the world's biggest trial of gene therapy for cystic fibrosis.

Funded by the Cystic Fibrosis Trust, the Medical Research Council and The National Institute for Health Research , the trial will treat 120 CF patients with either a placebo or a healthy copy of the gene that causes CF. The gene is wrapped up in a fat globule, or liposome and delivered in aerosol form directly to the lungs.

(Image: Eric Alton)

Gene Therapy

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