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BBC World Service

Discovery

Many people are living with chronic diseases such as rheumatoid arthritis and inflammatory bowel conditions in which the body attacks itself. Although drug treatments have improved over recent years they do not work for everyone and can have serious side effects. 

Now researchers such as neurologist Dr Kevin Tracey of the Feinstein Institute for Medical Research, and rheumatologist professor Paul-Peter Tak of Amsterdam University, are trying a new approach to improving the lives of these patients. They are firing electrical pulses along the vagus nerve, a major nerve that connects the brain with all the organs. The technology to do this has been around for some decades as stimulating the vagus nerve has been used to help people who have epilepsy that is not controlled with drugs since the 1990s. 
Gaia Vince talks to these pioineers of this new field of research. And, she hears how there may be ways of improving the tone of the vagal nerve using meditation.

(Image: Vagus Nerve Stimulation. Credit: Getty Images)

Vagus Nerve

Throbbing head, nausea, dizziness, disturbed vision – just some of the disabling symptoms that can strike during a migraine attack. This neurological condition is far more common than you might think, affecting more people than diabetes, epilepsy and asthma combined.

While medications, to help relieve the symptoms of migraine, have been around for some time, they haven’t worked for everyone. And what happens in the brain during a migraine attack was, until recently, poorly understood.

Peter Goadsby is Professor of Neurology at King's College London’s Institute of Psychiatry, Psychology & Neuroscience and is a true pioneer in the field of migraine.

Over the course of his career, he has unravelled what happens in the brain during a migraine attack and his insights are already benefiting patients - in the form of new medications that can not only treat a migraine, but also prevent it from occurring.

Peter shares this year’s Brain Prize, the world's largest prize for brain research, with three other internationally renowned scientists in the field.

The Life Scientific - Peter Goadsby

From the Hay Festival, James and a panel of experts explain what we can all do to help ourselves age well.

We discover what’s going on in our bodies when we age, the difference between biological and chronological age, as well as getting the audience moving for a physical test.

James is joined by gerontologist Sarah Harper from the University of Oxford, biomedical scientist Georgina Ellison-Hughes from King’s College London, and doctor Norman Lazarus to understand how exercise, diet, and mental health all have a part to play in how we age.

Inside Health: How can we age well?

Dr Chris van Tulleken shares stories from the making of his chart-topping podcast, Fed. In conversation with Leyla Kazim, at Hay Festival 2024.

In Fed, Dr Chris van Tulleken, investigated the entangled web of forces that shape what ends up on our plates. And he focused his investigation around one foodstuff in particular. The most widely eaten meat on our planet, a staple of nearly every diet and a global food production phenomenon: the humble chicken, Chris dug into the history of our relationship with this extraordinary animal, to try to get to the truth of why we eat so much of it, and what that means for the birds, for us, and for the planet.

In this lively conversation, recorded live at Hay festival 2024, Chris talks to Leyla Kazim about the hidden stories behind the globalised food networks of today. From industrial-scale farming, to food labelling, to ethical dilemmas, environmental quandaries, and the complexities of the world of fast food. Plus tales from the adventure that ran through the whole series: raising his own tiny flock of broiler chickens, in his back garden.

Hay Festival Special

Perhaps you couldn't drift off, or maybe you woke in the middle of the night and then couldn't nod off again.
In this edition of Inside Health we're talking all about insomnia. It’s an issue that may affect many of us at some point in our lives – but for some it goes beyond a short period of not being able to sleep and becomes something more serious.
James is joined by a trio of experts ready to answer to them: Dr Allie Hare, president of the British Sleep Society and consultant physician in sleep medicine at the Royal Brompton Hospital, Colin Espie, a professor of sleep medicine at Oxford University and Dr Faith Orchard, a lecturer in psychology at Sussex University. We’re going to find out why we get insomnia, when to seek help and how much factors like ageing, menopause, needing the loo or shift work matter. And we'll look at the latest advice and treatments. Can insomnia be fixed?

Inside Health: Can Insomnia be fixed?

In 2016, Niall McCann was left with a bruised spinal cord when he crashed his speed glider into the side of a mountain at 50mph.

He shares his journey to recovery and some unexpected life lessons he has had to navigate, from soiling himself in inconvenient places and not being able to control his flatulence, to having to re-learn how to have sex again.

We also hear from a Mountain Rescue medic on what looked like an “unsurvivable” situation and Niall’s surgeon on fixing his “exploded” spine.

Inside Health: Life after my mountain accident

A mathematician searching for love discovers that relationships aren’t always as simple as equations—are his calculations the issue, or is there something deeper at play? Meanwhile, at an engineering conference, a young researcher’s seemingly minor mistake uncovers a scandal of epic proportions. Can numbers find love or unveil problems? From personal dilemmas to professional revelations, this episode dives into the unexpected ways numbers can change lives.

Uncharted: Love Bytes

Amid the desperation of war-starved Netherlands, a doctor defies conventional wisdom to save gravely ill children, uncovering a treatment that sparks both hope and controversy. Years later, in 1967, a young female researcher detects a strange, pulsing signal. Could it be mundane interference or evidence of alien life? From lifesaving breakthroughs to cosmic discoveries, this story celebrates the determination of pioneers who challenge convention and pursue truth against the odds.

Uncharted: The grain of truth

A PhD student with a passion for whales stumbles upon a strange, eerie sound deep beneath the ocean waves, something that will soon rock her world. Meanwhile, a fisherman is stranded in the ocean late at night, completely alone. With time running out, can he be rescued before it is too late? From mysterious discoveries to life-or-death struggles, this story delves into the power of the ocean and the determination to survive.

Uncharted: Songs of the sea

At a conference in Mexico, one scientist’s outburst sparks a global quest to find a ‘golden spike’ - the boundary marking the shift into a new geological period dominated by humans, not volcanoes or asteroids. From plastics and concrete to nuclear fallout, the data they uncover reveals a planet profoundly altered. But can they convince their colleagues and the world of the extent of this transformation? Meanwhile, in a small Italian city nestled in the Apennine mountains, a series of low-level tremors raise the question: Is this just a passing phase, or a warning of something much more devastating?

Uncharted: The golden spike

Jim al-Khalili talks to professor Elspeth Garman about a technique that has led to 28 Nobel Prizes in the last century.

X- ray crystallography, now celebrating its 100th anniversary, is used to study the internal structure of matter. It may sound rather arcane but it is the reason we now know the structure of hugely important molecules, like penicillin, insulin and DNA. But while other scientists scoop up prizes for cracking chemical structures, Elspeth works away behind the scenes, (more cameraman than Hollywood star), improving the methods and techniques used by everybody working in the field. 

If only it was as simple as putting a crystal in the machine and printing off the results. Growing a single crystal of an enzyme that gives TB its longevity took Elspeth's team no less than 15 years. No pressure there then when harvesting that precious commodity.

(Photo: Professor Elspeth Garman)

Elspeth Garman

Lyt når som helst, hvor som helst

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