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Lost Women of Science


For every Marie Curie or Rosalind Franklin whose story has been told, hundreds of female scientists remain unknown to the public at large. In this series, we illuminate the lives and work of a diverse array of groundbreaking scientists who, because of time, place and gender, have gone largely unrecognized. Each season we focus on a different scientist, putting her narrative into context, explaining not just the science but also the social and historical conditions in which she lived and worked. We also bring these stories to the present, painting a full picture of how her work endures.


At this festive time of year, when many people are bringing trees into their homes to decorate for the holidays, we are going back to our story of a pioneering scientist who made it her mission to ensure that plants traveling across borders did not carry any diseases. It was in 1909, that the Mayor of Tokyo sent a gift of 2,000 prized cherry trees to Washington, D.C. But the iconic blossoms enjoyed each spring along the Tidal Basin are not from those trees. That’s because Flora Patterson, who was the Mycologist in Charge at the USDA, recognized the original saplings were infected, and the shipment was burned on the National Mall. In this episode, we explore Patterson’s lasting impact on the field of mycology, starting with a blight that killed off the American chestnut trees, and how she helped make the USDA’s National Fungus Collection the largest in the world.

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Best Of: Flora Patterson, the Woman who Kept Devastating Blights from U.S. Shores

Dr. Katalin Karikó, a Hungarian-born biochemist, dedicated her life’s work to messenger RNA, which she always believed had the potential to change the world. After decades of being ignored, she persisted with the research that eventually revolutionized the field of medicine and enabled the development of lifesaving vaccines in record time during the COVID-19 pandemic. Dr. Karikó tells her story in her memoir, Breaking Through: My Life In Science, sharing her journey from young researcher in Hungary to Nobel Prize-winning biochemist.

In this conversation, she reflects on the challenges and breakthroughs that defined her career, her resilience, and the scientific curiosity that fueled her passion for mRNA research

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Lost Women of Science Conversations: Breaking Through

In honor of International Holocaust Remembrance Day, we are telling the story of Margarethe Hilferding, a pioneering psychoanalyst and physician from Vienna who was murdered in a Nazi concentration camp in 1942. She was the first woman to earn a medical degree at the University of Vienna and the first woman to join Sigmund Freud’s Vienna Psychoanalytic Society. In her paper On the Basis of Mother Love, presented to the society in 1911, she argued that the maternal instinct is not innate but can develop after birth, a theory Freud and the rest of her male colleagues rejected. Margarethe soon left the society and devoted much of her life to treating women in working class neighborhoods and advocating for their reproductive health. Her theory of maternal instinct remains controversial even today.

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Margarethe Hilferding, Sigmund Freud, and the Conspiracy of Silence

In the mid-1950s Marthe Gautier, a young French doctor and cytogenetics researcher, led a cutting-edge experiment to investigate the cause of Down syndrome. She painstakingly cultured cells in a ramshackle lab until one day she discovered an extra chromosome in the cells of patients with Down syndrome. This proved beyond a doubt that Down syndrome is genetic.

In this first episode of our two-part series about Gautier, she sees her discovery appropriated by a male colleague as he rushes to publish her findings. Jérôme Lejeune is listed as the lead author of the discovery even though Gautier did the work. Her name is listed second on this groundbreaking paper, published in 1959. And to add insult to injury, it is misspelled. It will take decades for Gautier to speak out.

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Who Discovered the Cause of Down Syndrome? Episode One

In 1960 Marthe Gautier left the lab where she had discovered the genetic cause of Down syndrome, and went on to have a successful career as a pediatric cardiologist. For decades, she remained silent as her former colleague Jérôme Lejeune continued to take credit for this pioneering discovery, and history wrote her out of the story. Until 2009. On the 50th anniversary of the paper that announced the discovery of trisomy 21, she decided to set the record straight. The process of changing history did not always go smoothly. In 2014, at the age of 88, she was set to give a talk and receive a medal at a conference, but the event was canceled hours in advance, and she was given the medal privately the next day. Finally, toward the end of her life, Gautier got the recognition she deserved. Before she died in 2022, she was also decorated by the French government for her contributions to science. 

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Who Discovered the Cause of Down Syndrome ? Episode Two

Lisa See’s novel Lady Tan’s Circle of Women is inspired by a medical textbook published in 1511 by an eminent female doctor, Tan Yunxian. In this episode, we talk to See about the origin of her novel, and to Lorraine Wilcox, the scholar who translated the original Chinese text, about what the practice of medicine was like for a female doctor during the Ming Dynasty. Tan Yunxian was almost lost to history, but the chronicle of her cases was reprinted by a great nephew and, amazingly, one copy survived through the centuries. Through serendipitous scholarly connections, Wilcox translated it and See used that translation as the inspiration for her novel.

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Lost Women of Science Conversations: Lady Tan's Circle of Women

In the 1880s, a small Afro-Dominican girl spent her days selling sweets on the streets of San Pedro de Macorís, a bustling port town in the Dominican Republic. Born out of wedlock and abandoned by her parents, her horizons seemed narrow — in this deeply stratified society, few people ever broke free from the life they were born into.

But Andrea Evangelina Rodríguez Perozo had something that made people take notice. Two influential brothers, both poets and intellectuals, recognized a brilliant mind and a tenacious spirit. With the brothers’ support, Evangelina went on to chart a path that was unheard of for any Dominican woman at that time: she became her country’s first female doctor.

In this five-part season, we will follow Evangelina as she studies medicine, first in her home country, then in Paris, where she learns new medical techniques in the emerging field of gynecology and encounters radical ideas about women’s health: ideas that she hopes will transform her society back in the Dominican Republic. Little does she think her new approaches to women’s health will eventually lead to her tragic downfall. Evangelina Rodríguez’s contributions as a reformer and pioneer in public health were all but erased by the dictator whose regime hounds her to death. Here, we piece together her life and her legacy. 

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The Extraordinary Life and Tragic Death of Evangelina Rodríguez Perozo

En la década de 1880, una pequeña niña Afro-Dominicana pasaba sus días vendiendo dulces en las calles de San Pedro de Macorís, una bulliciosa ciudad portuaria en la República Dominicana. Abandonada por sus padres, quienes la tuvieron por fuera del matrimonio, su futuro parecía gris: en esta sociedad profundamente estratificada, pocas personas lograban escapar de la vida en la que habían nacido.

Pero Andrea Evangelina Rodríguez Perozo tenía algo que hacía que los demás se fijaran en ella. Así ocurrió con dos hermanos influyentes, ambos poetas e intelectuales, quienes reconocieron en ella una mente brillante y un espíritu tenaz. Con el apoyo de ellos, Evangelina logró hacerse un camino inimaginable: convertirse en la primera mujer médica de su país.

En esta temporada de cinco capítulos seguiremos a Evangelina mientras estudia medicina, primero en su país natal y luego en París, donde aprende nuevas técnicas en el campo emergente de la ginecología y se encuentra con ideas radicales sobre la salud de las mujeres, ideas que espera transformen la sociedad de su país natal. 

Poco imaginaba que sus nuevos enfoques sobre la salud femenina eventualmente la llevarían a su trágica caída. Las contribuciones de Evangelina Rodríguez como reformadora y pionera de la salud pública serían prácticamente borradas por el dictador cuyo régimen la persigue hasta su muerte. Aquí reconstruimos su vida y su legado.

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La Extraordinaria Vida y Trágica Muerte de Evangelina Rodríguez Perozo

In the late 1890s, Andrea Evangelina Rodríguez Perozo, known as Evangelina, was just another poor girl trying to survive in the provincial town of San Pedro de Macorís in the Dominican Republic. Her life took an extraordinary turn when two brothers, both poets and writers, arrived from the capital. They noticed something special about the young girl who lived nearby. With their help, Evangelina went to school and, against overwhelming odds, decided to become a doctor. She was the first woman to enter medical school in the Dominican Republic, and when she graduated in 1911 she became the country's first female doctor. But just as she was about to start her career an unexpected tragedy changed the course of her life.

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La Doctora | 1

A finales de la década de 1890, Andrea Evangelina Rodríguez Perozo era una de las tantas niñas pobres luchando por sobrevivir en la ciudad de San Pedro de Macorís, en la República Dominicana. Su vida dio un giro extraordinario cuando dos hermanos, poetas y escritores, llegaron de la capital. Notaron algo especial en la joven, quien vivía cerca. Con su ayuda, Evangelina fue a la escuela y, contra todo pronóstico, decidió ser médica. Fue la primera mujer en estudiar en una escuela de medicina en la República Dominicana y, cuando se graduó en 1911, se convirtió en la primera doctora del país. Pero justo cuando estaba a punto de empezar su carrera, una tragedia inesperada cambiaría el curso de su vida.

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La doctora | 1

In our final episode, we explore Dorothy Andersen’s legacy—what she left behind and how her work has lived on since her death. Describing her mentor’s influence on her life and career, Dr. Celia Ores gives us a rare look into what Dr. Andersen was really like. We then turn to researchers, doctors, and patients, who fill us in on the progress that has grown from Dr. Andersen’s initial work. These major developments include the discovery of the cystic fibrosis gene, the tremendous impact of the drug Trikafta, and the lifesaving potential of gene editing techniques.

Access a transcript of the episode here: https://www.scientificamerican.com/article/lost-women-of-science-episode-4-breakfast-in-the-snow/

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The Pathologist in the Basement: Chapter 4

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