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Lost Women of Science


For every Marie Curie or Rosalind Franklin whose story has been told, hundreds of female scientists remain unknown to the public at large. In this series, we illuminate the lives and work of a diverse array of groundbreaking scientists who, because of time, place and gender, have gone largely unrecognized. Each season we focus on a different scientist, putting her narrative into context, explaining not just the science but also the social and historical conditions in which she lived and worked. We also bring these stories to the present, painting a full picture of how her work endures.


For every Marie Curie or Rosalind Franklin whose story has been told, hundreds of female scientists remain unknown to the public at large. We illuminate the lives and work of a diverse array of groundbreaking scientists who, because of time, place and gender, have gone largely unrecognized. Each season focuses on one scientist, putting her narrative into context, explaining not just the science but also the social and historical conditions in which she lived and worked. We also bring these stories to the present, painting a full picture of how her work endures.

Lost Women of Science: Trailer

When Dr. Dorothy Andersen confronted a slew of confounding infant deaths, she knew the accepted diagnosis couldn’t be right. Her medical detective work led to our current understanding of Cystic Fibrosis, a disease that circuitously impacts the pancreas and lungs. But she is by no means a household name, and the details of her life get scarcer every day. Who was this scientist, and how did she come to quietly make such an important medical contribution?

The Pathologist in the Basement: Trailer

When Dr. Dorothy Andersen confronted a slew of confounding infant deaths, she suspected the accepted diagnosis wasn’t right. Her medical sleuthing led to the world’s understanding of cystic fibrosis, a disease that affects the lungs, the pancreas, and a host of other organs. But hers is by no means a household name. Who was this scientist, and how did she come to quietly make such an important medical contribution? 

Access a transcript of the episode here: https://www.scientificamerican.com/article/the-lost-women-of-science-episode-1-the-question-mark/

The Pathologist in the Basement: Chapter 1

A passionate outdoorswoman, a “rugged individualist,” and a bit of an enigma—the few traces Dr. Andersen left behind give us glimpses into who she was. In this episode, we track down people determined to stitch together her life. Our associate producer, Sophie McNulty, rummages through the basement of Dr. Andersen’s colleague for clues about the elusive pathologist. Meanwhile, in Manhattan, pediatric intensivist Scott Baird suggests we take a second look at the conventional wisdom surrounding the evolution of cystic fibrosis research in the 1950s.

Access a transcript of the episode here: https://www.scientificamerican.com/article/lost-women-of-science-episode-2-the-matilda-effect/

The Pathologist in the Basement: Chapter 2

A missing portrait of Dr. Andersen takes us on a journey into the perils of memorialization—and who gets to be remembered. Dr. Scott Baird hunts for the portrait, and Drs. Nientara Anderson and Lizzy Fitzsousa, former medical students at Yale, explain how, in today’s diverse communities, “dude walls” can have an insidious effect on those who walk past them every day.

Access a transcript of the episode here: https://www.scientificamerican.com/article/lost-women-of-science-episode-3-the-case-of-the-missing-portrait/

The Pathologist in the Basement: Chapter 3

In our final episode, we explore Dorothy Andersen’s legacy—what she left behind and how her work has lived on since her death. Describing her mentor’s influence on her life and career, Dr. Celia Ores gives us a rare look into what Dr. Andersen was really like. We then turn to researchers, doctors, and patients, who fill us in on the progress that has grown from Dr. Andersen’s initial work. These major developments include the discovery of the cystic fibrosis gene, the tremendous impact of the drug Trikafta, and the lifesaving potential of gene editing techniques.

Access a transcript of the episode here: https://www.scientificamerican.com/article/lost-women-of-science-episode-4-breakfast-in-the-snow/

The Pathologist in the Basement: Chapter 4

In 1949, at the height of his career, Rustin McIntosh, the director of pediatrics at Columbia University’s Babies Hospital, submitted his letter of resignation. Dr. Scott Baird, who wrote a biography on Dorothy Andersen, takes us back to this pivotal moment, which occurred at the dawn of pediatric pathology in the United States. Through archival resources, Scott explores the institutional tensions that led to this abrupt resignation. At the eye of the storm is a character we’ve come to know well, perhaps the most important person working in pediatric pathology at the time: Dr. Dorothy Andersen.

Access a transcript of the episode here: https://www.scientificamerican.com/article/lost-women-of-science-podcast-bonus-episode-the-resignation/

The Pathologist in the Basement: The Resignation

The first modern-style code executed on a computer was written in the 1940s by a woman named Klára Dán von Neumann–or Klári to her family and friends. And the historic program she wrote was used to optimize nuclear weapons. This season, we dive into this fascinating moment in postwar America through Klári’s work. We explore the evolution of early computers, the vital role women played in early programming, and the inescapable connection between computing and war.

A Grasshopper in Very Tall Grass: Trailer

To understand how Klára Dán von Neumann arrived at computer programming, we need to first understand where she came from. Born in Budapest to a wealthy Jewish family, Klári grew up surrounded by artists, playwrights, and intellectuals. Her first marriage, to an inveterate gambler, took her on a tour of Europe’s casinos, and in one of them, she had a chance encounter with the famous mathematician, John von Neumann.

Access a transcript of the episode here: https://www.scientificamerican.com/article/lost-women-of-science-podcast-season-2-episode-one-the-grasshopper/

A Grasshopper in Tall Grass: Chapter 1

With John von Neumann absorbed in work, Klári struggles to find a niche in her new suburban home while dealing with devastating losses. A new chapter opens for Klári when the U.S. finally enters the war and women are called into the workforce.

Access a transcript of the episode here: https://www.scientificamerican.com/article/lost-women-of-science-podcast-season-2-episode-two-women-needed/

A Grasshopper in Tall Grass: Chapter 2

A few important things have happened in the three years since we first aired The Pathologist in the Basement, the story of Dr. Dorothy Andersen, the first to identify cystic fibrosis. It’s safe to say that Dr. Anderson is now a little less lost. In Episode 1, Dr. Andersen sleuths her way to the discovery of cystic fibrosis, a fatal disease that affects the lungs, the pancreas, and a host of other organs. So, who was Dorothy Andersen, and how did she come to make this seminal medical contribution?

Revisiting the Pathologist in the Basement

Revisiting the Pathologist in the Basement

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